DPYSL4 (dihydropyrimidinase like 4)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 10570
• Gene name: Dihydropyrimidinase like 4
• Gene symbol: DPYSL4
• Synonyms (NCBI Gene): CRMP3, DRP-4, ULIP4
• Chromosome: 10
• Chromosome location: 10q26.3

miRNA Show/Hide all (45)

miRTarBase ID	miRNA	Experiments	Reference
MIRT945061	hsa-miR-2355-5p	CLIP-seq
MIRT945062	hsa-miR-296-5p	CLIP-seq
MIRT945063	hsa-miR-3151	CLIP-seq
MIRT945064	hsa-miR-3177-3p	CLIP-seq
MIRT945065	hsa-miR-3177-5p	CLIP-seq
MIRT945066	hsa-miR-320a	CLIP-seq
MIRT945067	hsa-miR-320b	CLIP-seq
MIRT945068	hsa-miR-320c	CLIP-seq
MIRT945069	hsa-miR-320d	CLIP-seq
MIRT945070	hsa-miR-3653	CLIP-seq
MIRT945071	hsa-miR-3909	CLIP-seq
MIRT945072	hsa-miR-4302	CLIP-seq
MIRT945073	hsa-miR-4429	CLIP-seq
MIRT945074	hsa-miR-4505	CLIP-seq
MIRT945075	hsa-miR-4640-5p	CLIP-seq
MIRT945076	hsa-miR-4726-5p	CLIP-seq
MIRT945077	hsa-miR-520d-5p	CLIP-seq
MIRT945078	hsa-miR-524-5p	CLIP-seq
MIRT1979748	hsa-miR-1286	CLIP-seq
MIRT1979749	hsa-miR-214	CLIP-seq
MIRT1979750	hsa-miR-3619-5p	CLIP-seq
MIRT1979751	hsa-miR-3649	CLIP-seq
MIRT1979752	hsa-miR-3661	CLIP-seq
MIRT1979753	hsa-miR-492	CLIP-seq
MIRT1979754	hsa-miR-631	CLIP-seq
MIRT1979755	hsa-miR-761	CLIP-seq
MIRT1979756	hsa-miR-885-3p	CLIP-seq
MIRT2519463	hsa-miR-129-3p	CLIP-seq
MIRT2519464	hsa-miR-3157-5p	CLIP-seq
MIRT2519465	hsa-miR-3184	CLIP-seq
MIRT2519466	hsa-miR-423-5p	CLIP-seq
MIRT2519467	hsa-miR-4283	CLIP-seq
MIRT2519468	hsa-miR-4690-3p	CLIP-seq
MIRT2519469	hsa-miR-4753-3p	CLIP-seq
MIRT2519470	hsa-miR-526b	CLIP-seq
MIRT2519471	hsa-miR-942	CLIP-seq
MIRT2519463	hsa-miR-129-3p	CLIP-seq
MIRT2519464	hsa-miR-3157-5p	CLIP-seq
MIRT2519465	hsa-miR-3184	CLIP-seq
MIRT2519466	hsa-miR-423-5p	CLIP-seq
MIRT2519467	hsa-miR-4283	CLIP-seq
MIRT2519468	hsa-miR-4690-3p	CLIP-seq
MIRT2519469	hsa-miR-4753-3p	CLIP-seq
MIRT2519470	hsa-miR-526b	CLIP-seq
MIRT2519471	hsa-miR-942	CLIP-seq

Gene ontology (GO) Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004157	Function	Dihydropyrimidinase activity	IBA
GO:0005515	Function	Protein binding	IPI	21900206, 25416956, 32814053, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0006208	Process	Pyrimidine nucleobase catabolic process	IBA
GO:0007399	Process	Nervous system development	TAS	9652388
GO:0016787	Function	Hydrolase activity	IEA
GO:0016810	Function	Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	IEA
GO:0016812	Function	Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	IBA
GO:0031005	Function	Filamin binding	IPI	25358863

Other IDs

• MIM: 608407
• HGNC: 3016
• e!Ensembl: ENSG00000151640

Protein

• UniProt ID: O14531
• Protein name: Dihydropyrimidinase-related protein 4 (DRP-4) (Collapsin response mediator protein 3) (CRMP-3) (UNC33-like phosphoprotein 4) (ULIP-4)
• Protein function: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).
• PDB: 5NKS
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01979	Amidohydro_1	64 → 453	Amidohydrolase family	Domain

• Sequence:

  MSFQGKKSIPRITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDA
  HGLMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAY
  EQWRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQ
  MYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAV
  TIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAA
  FVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEE
  RMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKII
  SAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYK
  RIKARNRLAEIHGVPRGLYDGPVHEVMVPAKPGSGAPARASCPGKISVPPVRNLHQSGFS
  LSGSQADDHIARRTAQKIMAPPGGRSNITSLS

• Sequence length: 572

Pathways

Reactome Pathway:

CRMPs in Sema3A signaling

Related Genes

No strongly related genes found yet for DPYSL4.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to DPYSL4.