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Gene Gene information from NCBI Gene database.
Entrez ID 285381
Gene name Diphthamide biosynthesis 3
Gene symbol DPH3
Synonyms (NCBI Gene)
DELGIPDELGIP1DESR1DPH3AKTI11ZCSL2
Chromosome 3
Chromosome location 3p25.1
Summary This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to diphthamide. This modified resi
miRNA miRNA information provided by mirtarbase database.
673 Show/Hide all (673)
miRTarBase ID miRNA Experiments Reference
MIRT668687 hsa-miR-6507-3p HITS-CLIP 23824327
MIRT090976 hsa-miR-1250-3p HITS-CLIP 23824327
MIRT354885 hsa-miR-153-5p HITS-CLIP 23824327
MIRT668686 hsa-miR-6072 HITS-CLIP 23824327
MIRT668685 hsa-miR-6891-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
18 Show/Hide all (18)
GO ID Ontology Definition Evidence Reference
GO:0002926 Process TRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation ISS
GO:0005515 Function Protein binding IPI 14980502, 25416956, 28514442, 32296183, 33961781
GO:0005634 Component Nucleus IDA 14980502
GO:0005634 Component Nucleus IEA
GO:0005654 Component Nucleoplasm IDA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
608959 27717 ENSG00000154813
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96FX2
Protein name Diphthamide biosynthesis protein 3 (CSL-type zinc finger-containing protein 2) (DelGEF-interacting protein 1) (DelGIP1)
Protein function Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a his
PDB 2JR7
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05207 zf-CSL 6 → 60 CSL zinc finger Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed with highest levels in small intestine, spleen, thymus, heart, liver and lung. {ECO:0000269|PubMed:14527407, ECO:0000269|PubMed:14980502}.
Sequence
Sequence length 82
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Synthesis of diphthamide-EEF2