DND1 (DND microRNA-mediated repression inhibitor 1)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 373863
• Gene name: DND microRNA-mediated repression inhibitor 1
• Gene symbol: DND1
• Synonyms (NCBI Gene): RBMS4
• Chromosome: 5
• Chromosome location: 5q31.3
• Summary: This gene encodes a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Reduced expression of this gene has been implicated in tongue squamous cell carcinoma. Two pseudogenes of this gene are located on th

miRNA Show/Hide all (102)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005766	hsa-miR-24-3p	Luciferase reporter assay, qRT-PCR, Western blot	20816961
MIRT942214	hsa-miR-186	CLIP-seq
MIRT942215	hsa-miR-3133	CLIP-seq
MIRT942216	hsa-miR-3165	CLIP-seq
MIRT942217	hsa-miR-320e	CLIP-seq
MIRT942218	hsa-miR-3612	CLIP-seq
MIRT942219	hsa-miR-4443	CLIP-seq
MIRT942220	hsa-miR-4639-5p	CLIP-seq
MIRT942221	hsa-miR-4659a-5p	CLIP-seq
MIRT942222	hsa-miR-4659b-5p	CLIP-seq
MIRT942223	hsa-miR-4699-5p	CLIP-seq
MIRT942224	hsa-miR-548aa	CLIP-seq
MIRT942225	hsa-miR-650	CLIP-seq
MIRT2214111	hsa-miR-1302	CLIP-seq
MIRT2214112	hsa-miR-4298	CLIP-seq
MIRT2214113	hsa-miR-4485	CLIP-seq
MIRT2214114	hsa-miR-4648	CLIP-seq
MIRT2214115	hsa-miR-7	CLIP-seq
MIRT2448441	hsa-miR-1207-3p	CLIP-seq
MIRT942214	hsa-miR-186	CLIP-seq
MIRT2448442	hsa-miR-22	CLIP-seq
MIRT2448443	hsa-miR-2355-5p	CLIP-seq
MIRT2448444	hsa-miR-24	CLIP-seq
MIRT2448445	hsa-miR-3065-5p	CLIP-seq
MIRT942215	hsa-miR-3133	CLIP-seq
MIRT2448446	hsa-miR-4284	CLIP-seq
MIRT2448447	hsa-miR-4286	CLIP-seq
MIRT2448448	hsa-miR-4436a	CLIP-seq
MIRT942220	hsa-miR-4639-5p	CLIP-seq
MIRT942223	hsa-miR-4699-5p	CLIP-seq
MIRT2448449	hsa-miR-4719	CLIP-seq
MIRT942224	hsa-miR-548aa	CLIP-seq
MIRT2448450	hsa-miR-548ac	CLIP-seq
MIRT2448451	hsa-miR-548ae	CLIP-seq
MIRT2448452	hsa-miR-548aj	CLIP-seq
MIRT2448453	hsa-miR-548am	CLIP-seq
MIRT2448454	hsa-miR-548d-3p	CLIP-seq
MIRT2448455	hsa-miR-548x	CLIP-seq
MIRT2448456	hsa-miR-548z	CLIP-seq
MIRT2448457	hsa-miR-583	CLIP-seq
MIRT2448458	hsa-miR-938	CLIP-seq
MIRT2448441	hsa-miR-1207-3p	CLIP-seq
MIRT2448442	hsa-miR-22	CLIP-seq
MIRT2448443	hsa-miR-2355-5p	CLIP-seq
MIRT2448444	hsa-miR-24	CLIP-seq
MIRT2448445	hsa-miR-3065-5p	CLIP-seq
MIRT2448446	hsa-miR-4284	CLIP-seq
MIRT2448447	hsa-miR-4286	CLIP-seq
MIRT2448448	hsa-miR-4436a	CLIP-seq
MIRT2448449	hsa-miR-4719	CLIP-seq
MIRT942224	hsa-miR-548aa	CLIP-seq
MIRT2448450	hsa-miR-548ac	CLIP-seq
MIRT2448451	hsa-miR-548ae	CLIP-seq
MIRT2448452	hsa-miR-548aj	CLIP-seq
MIRT2448453	hsa-miR-548am	CLIP-seq
MIRT2448454	hsa-miR-548d-3p	CLIP-seq
MIRT2448455	hsa-miR-548x	CLIP-seq
MIRT2448456	hsa-miR-548z	CLIP-seq
MIRT2448457	hsa-miR-583	CLIP-seq
MIRT2448458	hsa-miR-938	CLIP-seq
MIRT2448441	hsa-miR-1207-3p	CLIP-seq
MIRT942214	hsa-miR-186	CLIP-seq
MIRT2448442	hsa-miR-22	CLIP-seq
MIRT2448443	hsa-miR-2355-5p	CLIP-seq
MIRT2448444	hsa-miR-24	CLIP-seq
MIRT2448445	hsa-miR-3065-5p	CLIP-seq
MIRT942215	hsa-miR-3133	CLIP-seq
MIRT2448446	hsa-miR-4284	CLIP-seq
MIRT2448447	hsa-miR-4286	CLIP-seq
MIRT2448448	hsa-miR-4436a	CLIP-seq
MIRT2448449	hsa-miR-4719	CLIP-seq
MIRT942224	hsa-miR-548aa	CLIP-seq
MIRT2448450	hsa-miR-548ac	CLIP-seq
MIRT2448451	hsa-miR-548ae	CLIP-seq
MIRT2448452	hsa-miR-548aj	CLIP-seq
MIRT2448453	hsa-miR-548am	CLIP-seq
MIRT2448454	hsa-miR-548d-3p	CLIP-seq
MIRT2448455	hsa-miR-548x	CLIP-seq
MIRT2448456	hsa-miR-548z	CLIP-seq
MIRT2448457	hsa-miR-583	CLIP-seq
MIRT2448458	hsa-miR-938	CLIP-seq
MIRT2448441	hsa-miR-1207-3p	CLIP-seq
MIRT942214	hsa-miR-186	CLIP-seq
MIRT2448442	hsa-miR-22	CLIP-seq
MIRT2448443	hsa-miR-2355-5p	CLIP-seq
MIRT2448444	hsa-miR-24	CLIP-seq
MIRT2448445	hsa-miR-3065-5p	CLIP-seq
MIRT942215	hsa-miR-3133	CLIP-seq
MIRT2448446	hsa-miR-4284	CLIP-seq
MIRT2448447	hsa-miR-4286	CLIP-seq
MIRT2448448	hsa-miR-4436a	CLIP-seq
MIRT2448449	hsa-miR-4719	CLIP-seq
MIRT942224	hsa-miR-548aa	CLIP-seq
MIRT2448450	hsa-miR-548ac	CLIP-seq
MIRT2448451	hsa-miR-548ae	CLIP-seq
MIRT2448452	hsa-miR-548aj	CLIP-seq
MIRT2448453	hsa-miR-548am	CLIP-seq
MIRT2448454	hsa-miR-548d-3p	CLIP-seq
MIRT2448455	hsa-miR-548x	CLIP-seq
MIRT2448456	hsa-miR-548z	CLIP-seq
MIRT2448457	hsa-miR-583	CLIP-seq
MIRT2448458	hsa-miR-938	CLIP-seq

Gene ontology (GO) Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	IEA
GO:0003729	Function	MRNA binding	IBA
GO:0003730	Function	MRNA 3'-UTR binding	IDA	18155131
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	18155131
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	18155131
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005925	Component	Focal adhesion	IDA
GO:0007281	Process	Germ cell development	IEA
GO:0007281	Process	Germ cell development	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0035198	Function	MiRNA binding	IDA	18155131
GO:0048255	Process	MRNA stabilization	IBA
GO:0060965	Process	Negative regulation of miRNA-mediated gene silencing	IBA
GO:0060965	Process	Negative regulation of miRNA-mediated gene silencing	IDA	18155131
GO:0061158	Process	3'-UTR-mediated mRNA destabilization	IDA	28297718

Other IDs

• MIM: 609385
• HGNC: 23799
• e!Ensembl: ENSG00000256453

Protein

• UniProt ID: Q8IYX4
• Protein name: Dead end protein homolog 1 (RNA-binding motif, single-stranded-interacting protein 4)
• Protein function: RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of t
• PDB: 6LE1 , 7Q4L
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00076	RRM_1	60 → 126	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF14709	DND1_DSRM	253 → 333		Domain

• Sequence:

  MQSKRDCELWCERVNPENKAALEAWVRETGIRLVQVNGQRKYGGPPPGWVGSPPPAGSEV
  FIGRLPQDVYEHQLIPLFQRVGRLYEFRLMMTFSGLNRGFAYARYSSRRGAQAAIATLHN
  HPLRPSCPLLVCRSTEKCELSVDGLPPNLTRSALLLALQPLGPGLQEARLLPSPGPAPGQ
  IALLKFSSHRAAAMAKKALVEGQSHLCGEQVAVEWLKPDLKQRLRQQLVGPFLRSPQPEG
  SQLALARDKLGFQGARATLQLLCQRMKLGSPVFLTKCLGIGPAGWHRFWYQVVIPGHPVP
  FSGLIWVVLTLDGRDGHEVAKDAVSVRLLQALSESGANLLWSAGAEAGTMVKQ

• Sequence length: 353

Related Genes

No strongly related genes found yet for DND1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to DND1.