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Gene Gene information from NCBI Gene database.
Entrez ID 54788
Gene name DnaJ heat shock protein family (Hsp40) member B12
Gene symbol DNAJB12
Synonyms (NCBI Gene)
DJ10
Chromosome 10
Chromosome location 10q22.1
Summary DNAJB12 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the
miRNA miRNA information provided by mirtarbase database.
519 Show/Hide all (519)
miRTarBase ID miRNA Experiments Reference
MIRT028272 hsa-miR-32-5p Sequencing 20371350
MIRT030463 hsa-miR-24-3p Sequencing 20371350
MIRT049647 hsa-miR-92a-3p CLASH 23622248
MIRT049647 hsa-miR-92a-3p CLASH 23622248
MIRT049647 hsa-miR-92a-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
18 Show/Hide all (18)
GO ID Ontology Definition Evidence Reference
GO:0005634 Component Nucleus IEA
GO:0005783 Component Endoplasmic reticulum IDA 27916661
GO:0005783 Component Endoplasmic reticulum IEA
GO:0005789 Component Endoplasmic reticulum membrane IBA
GO:0005789 Component Endoplasmic reticulum membrane IDA 21148293, 21150129
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
608376 14891 ENSG00000148719
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NXW2
Protein name DnaJ homolog subfamily B member 12
Protein function Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:21148293,
PDB 2CTP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00226 DnaJ 110 → 171 DnaJ domain Domain
PF09320 DUF1977 262 → 368 Domain of unknown function (DUF1977) Family
Sequence
MESNKDEAERCISIALKAIQSNQPDRALRFLEKAQRLYPTPRVRALIESLNQKPQTAGDQ
PPPTDTTHATHRKAGGTDAPSANGEAGGESTKGYTAEQVAAVKRVKQCKDYYEILGVSRG
ASDEDLKKAYRRLALKFHPDKNHAPGATEAFKAIGTAYAVLSNPEKRKQYD
QFGDDKSQA
ARHGHGHGDFHRGFEADISPEDLFNMFFGGGFPSSNVHVYSNGRMRYTYQQRQDRRDNQG
DGGLGVFVQLMPILILILVSALSQLMVSSPPYSLSPRPSVGHIHRRVTDHLGVVYYVGDT
FSEEYTGSSLKTVERNVEDDYIANLRNNCWKEKQQKEGLLYRARYFGDTDMYHRAQKMGT
PSCSRLSE
VQASLHG
Sequence length 375
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway
Protein processing in endoplasmic reticulum