DIRAS1 (DIRAS family GTPase 1)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 148252
• Gene name: DIRAS family GTPase 1
• Gene symbol: DIRAS1
• Synonyms (NCBI Gene): Di-Ras1, GBTS1, RIG
• Chromosome: 19
• Chromosome location: 19p13.3
• Summary: DIRAS1 belongs to a distinct branch of the functionally diverse Ras (see HRAS; MIM 190020) superfamily of monomeric GTPases.[supplied by OMIM, Apr 2004]

miRNA Show/Hide all (190)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019097	hsa-miR-335-5p	Microarray	18185580
MIRT718511	hsa-miR-6871-3p	HITS-CLIP	19536157
MIRT718510	hsa-miR-4726-3p	HITS-CLIP	19536157
MIRT718509	hsa-miR-4286	HITS-CLIP	19536157
MIRT718508	hsa-miR-4258	HITS-CLIP	19536157
MIRT718507	hsa-miR-3663-3p	HITS-CLIP	19536157
MIRT637570	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT637569	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT478127	hsa-miR-552-3p	PAR-CLIP	23592263
MIRT478126	hsa-miR-4795-5p	PAR-CLIP	23592263
MIRT478125	hsa-miR-3175	PAR-CLIP	23592263
MIRT478124	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT478123	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT478122	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT478121	hsa-miR-6769a-5p	PAR-CLIP	23592263
MIRT478119	hsa-miR-6769b-5p	PAR-CLIP	23592263
MIRT478120	hsa-miR-491-5p	PAR-CLIP	23592263
MIRT478118	hsa-miR-6748-5p	PAR-CLIP	23592263
MIRT478117	hsa-miR-3150a-3p	PAR-CLIP	23592263
MIRT478116	hsa-miR-6763-5p	PAR-CLIP	23592263
MIRT478115	hsa-miR-4706	PAR-CLIP	23592263
MIRT718511	hsa-miR-6871-3p	HITS-CLIP	19536157
MIRT718510	hsa-miR-4726-3p	HITS-CLIP	19536157
MIRT718509	hsa-miR-4286	HITS-CLIP	19536157
MIRT718508	hsa-miR-4258	HITS-CLIP	19536157
MIRT718507	hsa-miR-3663-3p	HITS-CLIP	19536157
MIRT637570	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT637569	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT478127	hsa-miR-552-3p	PAR-CLIP	23592263
MIRT478126	hsa-miR-4795-5p	PAR-CLIP	23592263
MIRT478125	hsa-miR-3175	PAR-CLIP	23592263
MIRT478124	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT478123	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT478122	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT478121	hsa-miR-6769a-5p	PAR-CLIP	23592263
MIRT478119	hsa-miR-6769b-5p	PAR-CLIP	23592263
MIRT478120	hsa-miR-491-5p	PAR-CLIP	23592263
MIRT478118	hsa-miR-6748-5p	PAR-CLIP	23592263
MIRT478117	hsa-miR-3150a-3p	PAR-CLIP	23592263
MIRT478116	hsa-miR-6763-5p	PAR-CLIP	23592263
MIRT478115	hsa-miR-4706	PAR-CLIP	23592263
MIRT936929	hsa-miR-10a	CLIP-seq
MIRT936930	hsa-miR-10b	CLIP-seq
MIRT936931	hsa-miR-1205	CLIP-seq
MIRT936932	hsa-miR-1245b-3p	CLIP-seq
MIRT936933	hsa-miR-1245b-5p	CLIP-seq
MIRT936934	hsa-miR-127-3p	CLIP-seq
MIRT936935	hsa-miR-1293	CLIP-seq
MIRT936936	hsa-miR-1324	CLIP-seq
MIRT936937	hsa-miR-138	CLIP-seq
MIRT936938	hsa-miR-151-5p	CLIP-seq
MIRT936939	hsa-miR-151b	CLIP-seq
MIRT936940	hsa-miR-187	CLIP-seq
MIRT936941	hsa-miR-1972	CLIP-seq
MIRT936942	hsa-miR-224	CLIP-seq
MIRT936943	hsa-miR-23a	CLIP-seq
MIRT936944	hsa-miR-23b	CLIP-seq
MIRT936945	hsa-miR-23c	CLIP-seq
MIRT936946	hsa-miR-3120-3p	CLIP-seq
MIRT936947	hsa-miR-3142	CLIP-seq
MIRT936948	hsa-miR-3151	CLIP-seq
MIRT936949	hsa-miR-3613-3p	CLIP-seq
MIRT936950	hsa-miR-3653	CLIP-seq
MIRT936951	hsa-miR-3657	CLIP-seq
MIRT936952	hsa-miR-3665	CLIP-seq
MIRT936953	hsa-miR-3667-3p	CLIP-seq
MIRT936954	hsa-miR-370	CLIP-seq
MIRT936955	hsa-miR-371-5p	CLIP-seq
MIRT936956	hsa-miR-371b-5p	CLIP-seq
MIRT936957	hsa-miR-3907	CLIP-seq
MIRT936958	hsa-miR-3942-3p	CLIP-seq
MIRT936959	hsa-miR-3976	CLIP-seq
MIRT936960	hsa-miR-4263	CLIP-seq
MIRT936961	hsa-miR-431	CLIP-seq
MIRT936962	hsa-miR-4443	CLIP-seq
MIRT936963	hsa-miR-4447	CLIP-seq
MIRT936964	hsa-miR-4472	CLIP-seq
MIRT936965	hsa-miR-4483	CLIP-seq
MIRT936966	hsa-miR-4494	CLIP-seq
MIRT936967	hsa-miR-4520a-3p	CLIP-seq
MIRT936968	hsa-miR-4520b-3p	CLIP-seq
MIRT936969	hsa-miR-4650-5p	CLIP-seq
MIRT936970	hsa-miR-4695-5p	CLIP-seq
MIRT936971	hsa-miR-4772-3p	CLIP-seq
MIRT936972	hsa-miR-4772-5p	CLIP-seq
MIRT936973	hsa-miR-4773	CLIP-seq
MIRT936974	hsa-miR-4779	CLIP-seq
MIRT936975	hsa-miR-4781-3p	CLIP-seq
MIRT936976	hsa-miR-486-3p	CLIP-seq
MIRT936977	hsa-miR-499a-5p	CLIP-seq
MIRT936978	hsa-miR-500a	CLIP-seq
MIRT936979	hsa-miR-541	CLIP-seq
MIRT936980	hsa-miR-548q	CLIP-seq
MIRT936981	hsa-miR-556-5p	CLIP-seq
MIRT936982	hsa-miR-574-5p	CLIP-seq
MIRT936983	hsa-miR-597	CLIP-seq
MIRT936984	hsa-miR-604	CLIP-seq
MIRT936985	hsa-miR-615-5p	CLIP-seq
MIRT936986	hsa-miR-647	CLIP-seq
MIRT936987	hsa-miR-654-5p	CLIP-seq
MIRT936988	hsa-miR-657	CLIP-seq
MIRT936989	hsa-miR-668	CLIP-seq
MIRT936990	hsa-miR-765	CLIP-seq
MIRT936991	hsa-miR-939	CLIP-seq
MIRT936936	hsa-miR-1324	CLIP-seq
MIRT936942	hsa-miR-224	CLIP-seq
MIRT1977387	hsa-miR-25	CLIP-seq
MIRT1977388	hsa-miR-300	CLIP-seq
MIRT1977389	hsa-miR-3064-3p	CLIP-seq
MIRT1977390	hsa-miR-30a	CLIP-seq
MIRT1977391	hsa-miR-30b	CLIP-seq
MIRT1977392	hsa-miR-30c	CLIP-seq
MIRT1977393	hsa-miR-30d	CLIP-seq
MIRT1977394	hsa-miR-30e	CLIP-seq
MIRT1977395	hsa-miR-3125	CLIP-seq
MIRT1977396	hsa-miR-32	CLIP-seq
MIRT1977397	hsa-miR-342-3p	CLIP-seq
MIRT1977398	hsa-miR-363	CLIP-seq
MIRT1977399	hsa-miR-367	CLIP-seq
MIRT1977400	hsa-miR-381	CLIP-seq
MIRT1977401	hsa-miR-3916	CLIP-seq
MIRT1977402	hsa-miR-4325	CLIP-seq
MIRT1977403	hsa-miR-4643	CLIP-seq
MIRT1977404	hsa-miR-4701-5p	CLIP-seq
MIRT1977405	hsa-miR-4789-5p	CLIP-seq
MIRT1977406	hsa-miR-4797-5p	CLIP-seq
MIRT1977407	hsa-miR-495	CLIP-seq
MIRT936979	hsa-miR-541	CLIP-seq
MIRT1977408	hsa-miR-552	CLIP-seq
MIRT1977409	hsa-miR-570	CLIP-seq
MIRT1977410	hsa-miR-588	CLIP-seq
MIRT1977411	hsa-miR-642b	CLIP-seq
MIRT1977412	hsa-miR-653	CLIP-seq
MIRT936987	hsa-miR-654-5p	CLIP-seq
MIRT1977413	hsa-miR-92a	CLIP-seq
MIRT1977414	hsa-miR-92b	CLIP-seq
MIRT2212654	hsa-miR-1254	CLIP-seq
MIRT2212655	hsa-miR-185	CLIP-seq
MIRT2212656	hsa-miR-1915	CLIP-seq
MIRT2212657	hsa-miR-218	CLIP-seq
MIRT2212658	hsa-miR-22	CLIP-seq
MIRT936942	hsa-miR-224	CLIP-seq
MIRT2212659	hsa-miR-2355-5p	CLIP-seq
MIRT936943	hsa-miR-23a	CLIP-seq
MIRT936944	hsa-miR-23b	CLIP-seq
MIRT936945	hsa-miR-23c	CLIP-seq
MIRT2212660	hsa-miR-3116	CLIP-seq
MIRT2212661	hsa-miR-3183	CLIP-seq
MIRT2212662	hsa-miR-3689d	CLIP-seq
MIRT2212663	hsa-miR-3941	CLIP-seq
MIRT936959	hsa-miR-3976	CLIP-seq
MIRT2212664	hsa-miR-4290	CLIP-seq
MIRT2212665	hsa-miR-4306	CLIP-seq
MIRT936961	hsa-miR-431	CLIP-seq
MIRT2212666	hsa-miR-4455	CLIP-seq
MIRT2212667	hsa-miR-4637	CLIP-seq
MIRT1977403	hsa-miR-4643	CLIP-seq
MIRT2212668	hsa-miR-4644	CLIP-seq
MIRT2212669	hsa-miR-4649-3p	CLIP-seq
MIRT2212670	hsa-miR-4659a-5p	CLIP-seq
MIRT2212671	hsa-miR-4659b-5p	CLIP-seq
MIRT2212672	hsa-miR-466	CLIP-seq
MIRT2212673	hsa-miR-4672	CLIP-seq
MIRT1977404	hsa-miR-4701-5p	CLIP-seq
MIRT2212674	hsa-miR-4717-3p	CLIP-seq
MIRT2212675	hsa-miR-4723-3p	CLIP-seq
MIRT2212676	hsa-miR-4769-3p	CLIP-seq
MIRT1977405	hsa-miR-4789-5p	CLIP-seq
MIRT1977406	hsa-miR-4797-5p	CLIP-seq
MIRT936976	hsa-miR-486-3p	CLIP-seq
MIRT2212677	hsa-miR-544b	CLIP-seq
MIRT1977410	hsa-miR-588	CLIP-seq
MIRT2212678	hsa-miR-615-3p	CLIP-seq
MIRT1977411	hsa-miR-642b	CLIP-seq
MIRT2212679	hsa-miR-662	CLIP-seq
MIRT2386909	hsa-miR-4281	CLIP-seq
MIRT2386910	hsa-miR-4449	CLIP-seq
MIRT2386911	hsa-miR-4532	CLIP-seq
MIRT1977403	hsa-miR-4643	CLIP-seq
MIRT1977404	hsa-miR-4701-5p	CLIP-seq
MIRT2386912	hsa-miR-4787-5p	CLIP-seq
MIRT1977406	hsa-miR-4797-5p	CLIP-seq
MIRT1977410	hsa-miR-588	CLIP-seq
MIRT1977411	hsa-miR-642b	CLIP-seq
MIRT2448267	hsa-miR-1253	CLIP-seq
MIRT936938	hsa-miR-151-5p	CLIP-seq
MIRT936939	hsa-miR-151b	CLIP-seq
MIRT936970	hsa-miR-4695-5p	CLIP-seq
MIRT936974	hsa-miR-4779	CLIP-seq
MIRT936990	hsa-miR-765	CLIP-seq

Gene ontology (GO) Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003924	Function	GTPase activity	IBA
GO:0003924	Function	GTPase activity	IDA	12194967
GO:0003924	Function	GTPase activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183, 33961781
GO:0005525	Function	GTP binding	IBA
GO:0005525	Function	GTP binding	IDA	12194967
GO:0005525	Function	GTP binding	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	12194967
GO:0005886	Component	Plasma membrane	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0016020	Component	Membrane	IEA
GO:0019003	Function	GDP binding	IBA
GO:0043406	Process	Positive regulation of MAP kinase activity	IDA	12194967
GO:0051019	Function	Mitogen-activated protein kinase binding	IPI	12194967

Other IDs

• MIM: 607862
• HGNC: 19127
• e!Ensembl: ENSG00000176490

Protein

• UniProt ID: O95057
• Protein name: GTP-binding protein Di-Ras1 (Distinct subgroup of the Ras family member 1) (Ras-related inhibitor of cell growth) (Rig) (Small GTP-binding tumor suppressor 1)
• Protein function: Displays low GTPase activity and exists predominantly in the GTP-bound form.
• PDB: 2GF0
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00071	Ras	9 → 169	Ras family	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in heart and brain. {ECO:0000269|PubMed:12107278, ECO:0000269|PubMed:12194967}.
• Sequence:

  MPEQSNDYRVVVFGAGGVGKSSLVLRFVKGTFRDTYIPTIEDTYRQVISCDKSVCTLQIT
  DTTGSHQFPAMQRLSISKGHAFILVFSVTSKQSLEELGPIYKLIVQIKGSVEDIPVMLVG
  NKCDETQREVDTREAQAVAQEWKCAFMETSAKMNYNVKELFQELLTLETRRNMSLNIDGK
  RSGKQKRTDRVKGKCTLM

• Sequence length: 198

Related Genes

No strongly related genes found yet for DIRAS1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to DIRAS1.