Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	60625
Gene name	DEAH-box helicase 35
Gene symbol	DHX35
Synonyms (NCBI Gene)	C20orf15DDX35KAIA0875
Chromosome	20
Chromosome location	20q11.23-q12
Summary	DEAD box proteins characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mi

155 Show/Hide all (155)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030327	hsa-miR-26b-5p	Microarray	19088304
MIRT051221	hsa-miR-16-5p	CLASH	23622248
MIRT532153	hsa-miR-3120-3p	PAR-CLIP	22012620
MIRT532152	hsa-miR-330-3p	PAR-CLIP	22012620
MIRT532151	hsa-miR-545-3p	PAR-CLIP	22012620
MIRT532153	hsa-miR-3120-3p	PAR-CLIP	22012620
MIRT532152	hsa-miR-330-3p	PAR-CLIP	22012620
MIRT532151	hsa-miR-545-3p	PAR-CLIP	22012620
MIRT935522	hsa-miR-103a	CLIP-seq
MIRT935523	hsa-miR-107	CLIP-seq
MIRT935524	hsa-miR-1200	CLIP-seq
MIRT935525	hsa-miR-1228	CLIP-seq
MIRT935526	hsa-miR-1257	CLIP-seq
MIRT935527	hsa-miR-1296	CLIP-seq
MIRT935528	hsa-miR-15a	CLIP-seq
MIRT935529	hsa-miR-15b	CLIP-seq
MIRT935530	hsa-miR-16	CLIP-seq
MIRT935531	hsa-miR-195	CLIP-seq
MIRT935532	hsa-miR-2909	CLIP-seq
MIRT935533	hsa-miR-3126-3p	CLIP-seq
MIRT935534	hsa-miR-3128	CLIP-seq
MIRT935535	hsa-miR-3148	CLIP-seq
MIRT935536	hsa-miR-3150b-3p	CLIP-seq
MIRT935537	hsa-miR-3158-5p	CLIP-seq
MIRT935538	hsa-miR-34c-3p	CLIP-seq
MIRT935539	hsa-miR-3611	CLIP-seq
MIRT935540	hsa-miR-3622b-5p	CLIP-seq
MIRT935541	hsa-miR-377	CLIP-seq
MIRT935542	hsa-miR-3936	CLIP-seq
MIRT935543	hsa-miR-3974	CLIP-seq
MIRT935544	hsa-miR-424	CLIP-seq
MIRT935545	hsa-miR-4324	CLIP-seq
MIRT935546	hsa-miR-4326	CLIP-seq
MIRT935547	hsa-miR-4436b-3p	CLIP-seq
MIRT935548	hsa-miR-4446-3p	CLIP-seq
MIRT935549	hsa-miR-4477a	CLIP-seq
MIRT935550	hsa-miR-4666-5p	CLIP-seq
MIRT935551	hsa-miR-4668-5p	CLIP-seq
MIRT935552	hsa-miR-4688	CLIP-seq
MIRT935553	hsa-miR-4699-3p	CLIP-seq
MIRT935554	hsa-miR-4716-3p	CLIP-seq
MIRT935555	hsa-miR-4720-5p	CLIP-seq
MIRT935556	hsa-miR-4756-3p	CLIP-seq
MIRT935557	hsa-miR-4761-3p	CLIP-seq
MIRT935558	hsa-miR-4784	CLIP-seq
MIRT935559	hsa-miR-4795-3p	CLIP-seq
MIRT935560	hsa-miR-4799-3p	CLIP-seq
MIRT935561	hsa-miR-4802-5p	CLIP-seq
MIRT935562	hsa-miR-486-3p	CLIP-seq
MIRT935563	hsa-miR-494	CLIP-seq
MIRT935564	hsa-miR-497	CLIP-seq
MIRT935565	hsa-miR-544b	CLIP-seq
MIRT935566	hsa-miR-548c-3p	CLIP-seq
MIRT935567	hsa-miR-548g	CLIP-seq
MIRT935568	hsa-miR-548m	CLIP-seq
MIRT935569	hsa-miR-548v	CLIP-seq
MIRT935570	hsa-miR-577	CLIP-seq
MIRT935571	hsa-miR-610	CLIP-seq
MIRT935572	hsa-miR-616	CLIP-seq
MIRT935573	hsa-miR-625	CLIP-seq
MIRT935574	hsa-miR-765	CLIP-seq
MIRT935575	hsa-miR-3617	CLIP-seq
MIRT935576	hsa-miR-3689a-3p	CLIP-seq
MIRT935577	hsa-miR-3689c	CLIP-seq
MIRT935578	hsa-miR-4648	CLIP-seq
MIRT935579	hsa-miR-4654	CLIP-seq
MIRT935553	hsa-miR-4699-3p	CLIP-seq
MIRT935580	hsa-miR-4728-5p	CLIP-seq
MIRT935581	hsa-miR-4769-5p	CLIP-seq
MIRT935582	hsa-miR-4796-3p	CLIP-seq
MIRT935583	hsa-miR-548t	CLIP-seq
MIRT935584	hsa-miR-641	CLIP-seq
MIRT935585	hsa-miR-7	CLIP-seq
MIRT935522	hsa-miR-103a	CLIP-seq
MIRT935523	hsa-miR-107	CLIP-seq
MIRT935528	hsa-miR-15a	CLIP-seq
MIRT935529	hsa-miR-15b	CLIP-seq
MIRT935530	hsa-miR-16	CLIP-seq
MIRT935531	hsa-miR-195	CLIP-seq
MIRT1547969	hsa-miR-3649	CLIP-seq
MIRT935544	hsa-miR-424	CLIP-seq
MIRT935552	hsa-miR-4688	CLIP-seq
MIRT935561	hsa-miR-4802-5p	CLIP-seq
MIRT935562	hsa-miR-486-3p	CLIP-seq
MIRT935564	hsa-miR-497	CLIP-seq
MIRT1976949	hsa-miR-3661	CLIP-seq
MIRT1976950	hsa-miR-492	CLIP-seq
MIRT1976951	hsa-miR-631	CLIP-seq
MIRT2212299	hsa-miR-4641	CLIP-seq
MIRT2212300	hsa-miR-4763-5p	CLIP-seq
MIRT2515985	hsa-miR-10a	CLIP-seq
MIRT2515986	hsa-miR-10b	CLIP-seq
MIRT935524	hsa-miR-1200	CLIP-seq
MIRT935527	hsa-miR-1296	CLIP-seq
MIRT2515987	hsa-miR-1305	CLIP-seq
MIRT2515988	hsa-miR-1324	CLIP-seq
MIRT2515989	hsa-miR-1914	CLIP-seq
MIRT935532	hsa-miR-2909	CLIP-seq
MIRT2515990	hsa-miR-3074-3p	CLIP-seq
MIRT2515991	hsa-miR-3122	CLIP-seq
MIRT2515992	hsa-miR-3129-3p	CLIP-seq
MIRT2515993	hsa-miR-3163	CLIP-seq
MIRT2515994	hsa-miR-3183	CLIP-seq
MIRT2515995	hsa-miR-323-5p	CLIP-seq
MIRT2515996	hsa-miR-3613-3p	CLIP-seq
MIRT935576	hsa-miR-3689a-3p	CLIP-seq
MIRT935577	hsa-miR-3689c	CLIP-seq
MIRT2515997	hsa-miR-3909	CLIP-seq
MIRT2515998	hsa-miR-3913-5p	CLIP-seq
MIRT2515999	hsa-miR-3921	CLIP-seq
MIRT935543	hsa-miR-3974	CLIP-seq
MIRT2516000	hsa-miR-4251	CLIP-seq
MIRT2516001	hsa-miR-4252	CLIP-seq
MIRT2516002	hsa-miR-4286	CLIP-seq
MIRT935545	hsa-miR-4324	CLIP-seq
MIRT935546	hsa-miR-4326	CLIP-seq
MIRT2516003	hsa-miR-4329	CLIP-seq
MIRT935547	hsa-miR-4436b-3p	CLIP-seq
MIRT2212299	hsa-miR-4641	CLIP-seq
MIRT2516004	hsa-miR-4653-5p	CLIP-seq
MIRT2516005	hsa-miR-4696	CLIP-seq
MIRT2516006	hsa-miR-4714-5p	CLIP-seq
MIRT2516007	hsa-miR-4723-3p	CLIP-seq
MIRT2516008	hsa-miR-4725-5p	CLIP-seq
MIRT935556	hsa-miR-4756-3p	CLIP-seq
MIRT935557	hsa-miR-4761-3p	CLIP-seq
MIRT2516009	hsa-miR-4786-3p	CLIP-seq
MIRT935582	hsa-miR-4796-3p	CLIP-seq
MIRT935563	hsa-miR-494	CLIP-seq
MIRT2516010	hsa-miR-495	CLIP-seq
MIRT2516011	hsa-miR-498	CLIP-seq
MIRT2516012	hsa-miR-504	CLIP-seq
MIRT2516013	hsa-miR-513a-3p	CLIP-seq
MIRT935565	hsa-miR-544b	CLIP-seq
MIRT2516014	hsa-miR-548b-3p	CLIP-seq
MIRT935566	hsa-miR-548c-3p	CLIP-seq
MIRT935567	hsa-miR-548g	CLIP-seq
MIRT935568	hsa-miR-548m	CLIP-seq
MIRT935583	hsa-miR-548t	CLIP-seq
MIRT935569	hsa-miR-548v	CLIP-seq
MIRT935571	hsa-miR-610	CLIP-seq
MIRT935572	hsa-miR-616	CLIP-seq
MIRT2516015	hsa-miR-629	CLIP-seq
MIRT2516016	hsa-miR-876-3p	CLIP-seq
MIRT2516017	hsa-miR-889	CLIP-seq
MIRT2516018	hsa-miR-9	CLIP-seq
MIRT2516019	hsa-miR-938	CLIP-seq
MIRT2515994	hsa-miR-3183	CLIP-seq
MIRT2515997	hsa-miR-3909	CLIP-seq
MIRT2515999	hsa-miR-3921	CLIP-seq
MIRT2516000	hsa-miR-4251	CLIP-seq
MIRT2516003	hsa-miR-4329	CLIP-seq
MIRT2516004	hsa-miR-4653-5p	CLIP-seq
MIRT2516006	hsa-miR-4714-5p	CLIP-seq
MIRT2516007	hsa-miR-4723-3p	CLIP-seq

16 Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000398	Process	MRNA splicing, via spliceosome	IC	11991638
GO:0001701	Process	In utero embryonic development	IEA
GO:0003723	Function	RNA binding	IBA
GO:0003724	Function	RNA helicase activity	IEA
GO:0004386	Function	Helicase activity	IBA
GO:0004386	Function	Helicase activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0071013	Component	Catalytic step 2 spliceosome	IBA
GO:0071013	Component	Catalytic step 2 spliceosome	IDA	11991638

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q9H5Z1

Protein name

Probable ATP-dependent RNA helicase DHX35 (EC 3.6.4.13) (DEAH box protein 35)

Protein function

May be involved in pre-mRNA splicing.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00271	Helicase_C	258 → 398	Helicase conserved C-terminal domain	Family
PF04408	HA2	459 → 568	Helicase associated domain (HA2)	Domain
PF07717	OB_NTP_bind	606 → 685	Oligonucleotide/oligosaccharide-binding (OB)-fold	Domain

Sequence

MAAPVGPVKFWRPGTEGPGVSISEERQSLAENSGTTVVYNPYAALSIEQQRQKLPVFKLR
NHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTVAGRV
AEERGAVLGHEVGYCIRFDDCTDQLATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHE
RTLYTDIAIGLLKKIQKKRGDLRLIVASATLDADKFRDFFNQNETSDPARDTCVILTVEG
RTFPVDIFYLQSPVPDYIKSTVETVVKIHQTEGDGDVLAFLTGQEEVETVVSMLIEQARA
LARTGMKRHLRVLPMYAGLPSFEQMKVFERVSRSVRKVIVATNVAETSITISGIVYVIDC
GFVKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRSRSGKCYRLYTEEAFDKLPQSTVP
EMQRSNLAPVILQLKALGIDNVLRFHFMSPPPAQSMVQALELLYALGGLDKDCRLTEPLG
MRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNIFVVPPNQKSHAIRVHRKFAV
EEGDHLTMLNIYEAFIKHNKDSKWCQEHFLNYKGLVRAATVREQLKKLLVKFQVPRKSSE
GDPDLVLRCIVSGFFANAARFHSTGAYRTIRDDHELHIHPASVLYAEKPPRWVIYNEVIQ
TSKYYMRDVTAIESAWLLELAPHFYQQGTHLSLKAKRAKVQDP

Sequence length

703

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal. Show/Hide Unknown Diseases (8)
BASAL CELL CARCINOMA	—	GWAS catalog	31174203	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	29698419	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC KIDNEY DISEASE	—	GWAS catalog	21546767	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	37359372	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	29698419	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE	—	GWAS catalog	39024449	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
KERATINOCYTE CARCINOMA	—	GWAS catalog	31174203	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	30019117	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	26474385	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	21546767	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Optic Neuropathy Ischemic	Optic neuropathy	Pubtator	39273537	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	Pubtator	30569177	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Cancer Papillary	Papillary thyroid cancer	Pubtator	33551988	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

DHX35 (DEAH-box helicase 35)

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