Log in to bookmark this gene

Bookmark This Gene

Gene Gene information from NCBI Gene database.
Entrez ID 56919
Gene name DEAH-box helicase 33
Gene symbol DHX33
Synonyms (NCBI Gene)
DDX33
Chromosome 17
Chromosome location 17p13.2
Summary This gene encodes a member of the DEAD box protein family. The DEAD box proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA
miRNA miRNA information provided by mirtarbase database.
891 Show/Hide all (891)
miRTarBase ID miRNA Experiments Reference
MIRT022175 hsa-miR-124-3p Proteomics;Microarray 18668037
MIRT028394 hsa-miR-30a-5p Proteomics 18668040
MIRT032227 hsa-let-7b-5p Proteomics 18668040
MIRT050797 hsa-miR-17-5p CLASH 23622248
MIRT046349 hsa-miR-23b-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
39 Show/Hide all (39)
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000182 Function RDNA binding IDA 21930779
GO:0000182 Function RDNA binding IEA
GO:0003676 Function Nucleic acid binding IEA
GO:0003723 Function RNA binding HDA 22658674
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
614405 16718 ENSG00000005100
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9H6R0
Protein name ATP-dependent RNA helicase DHX33 (EC 3.6.4.13) (DEAH box protein 33)
Protein function Implicated in nucleolar organization, ribosome biogenesis, protein synthesis and cytoplasmic dsRNA sensing (By similarity) (PubMed:21930779, PubMed:23871209, PubMed:26100019). Stimulates RNA polymerase I transcription of the 47S precursor rRNA.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00270 DEAD 68 → 240 DEAD/DEAH box helicase Domain
PF00271 Helicase_C 267 → 410 Helicase conserved C-terminal domain Family
PF04408 HA2 471 → 562 Helicase associated domain (HA2) Domain
PF07717 OB_NTP_bind 620 → 697 Oligonucleotide/oligosaccharide-binding (OB)-fold Domain
Sequence
Sequence length 707
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway
NOD-like receptor signaling pathway
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
Cervical cancer Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (11)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Carcinoma of lung Lung carcinoma BEFREE 27601587
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Renal Cell Renal cell carcinoma Pubtator 32717723 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Glioblastoma Glioblastoma BEFREE 30552990
★★★★★
★☆☆☆☆
Found in Text Mining only
Glioblastoma Multiforme Glioblastoma BEFREE 30552990
★★★★★
★☆☆☆☆
Found in Text Mining only
Liver carcinoma Liver carcinoma BEFREE 27073163, 27693040
★★★★★
★☆☆☆☆
Found in Text Mining only
Lymphoma, Non-Hodgkin Non-Hodgkin lymphoma BEFREE 28498893
★★★★★
★☆☆☆☆
Found in Text Mining only
Lymphoma, Non-Hodgkin, Familial Lymphoma BEFREE 28498893
★★★★★
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of lung Lung Cancer BEFREE 27601587
★★★★★
★☆☆☆☆
Found in Text Mining only
Malignant Neoplasms Malignant Neoplasm BEFREE 27073163, 27601587, 28498893, 29870660, 30552990, 31182639
★★★★★
★☆☆☆☆
Found in Text Mining only
Neoplasms Neoplasms BEFREE 27073163, 27601587, 28498893
★★★★★
★☆☆☆☆
Found in Text Mining only