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Gene Gene information from NCBI Gene database.
Entrez ID 8562
Gene name Density regulated re-initiation and release factor
Gene symbol DENR
Synonyms (NCBI Gene)
DRPDRP1SMAP-3
Chromosome 12
Chromosome location 12q24.31
Summary This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains
miRNA miRNA information provided by mirtarbase database.
777 Show/Hide all (777)
miRTarBase ID miRNA Experiments Reference
MIRT051880 hsa-let-7b-5p CLASH 23622248
MIRT048024 hsa-miR-148a-3p CLASH 23622248
MIRT046970 hsa-miR-221-3p CLASH 23622248
MIRT046512 hsa-miR-15b-5p CLASH 23622248
MIRT039906 hsa-miR-615-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
12 Show/Hide all (12)
GO ID Ontology Definition Evidence Reference
GO:0001731 Process Formation of translation preinitiation complex IBA
GO:0001731 Process Formation of translation preinitiation complex IDA 20713520
GO:0002183 Process Cytoplasmic translational initiation IEA
GO:0002188 Process Translation reinitiation IBA
GO:0003743 Function Translation initiation factor activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604550 2769 ENSG00000139726
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O43583
Protein name Density-regulated protein (DRP) (Protein DRP1) (Smooth muscle cell-associated protein 3) (SMAP-3)
Protein function Translation regulator forming a complex with MCTS1 to promote translation reinitiation. Translation reinitiation is the process where the small ribosomal subunit remains attached to the mRNA following termination of translation of a regulatory u
PDB 5ONS , 5VYC , 6MS4 , 6VPQ , 6VPR
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01253 SUI1 111 → 186 Translation initiation factor SUI1 Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in heart and skeletal muscle and moderately expressed in the brain, placenta, liver and pancreas. Weakly expressed in the lung and kidney. {ECO:0000269|PubMed:9628587}.
Sequence
MAADISESSGADCKGDPRNSAKLDADYPLRVLYCGVCSLPTEYCEYMPDVAKCRQWLEKN
FPNEFAKLTVENSPKQEAGISEGQGTAGEEEEKKKQKRGGRGQIKQKKKTVPQKVTIAKI
PRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASVTGEDEIIIQGDFTDDIIDVIQE
KWPEVD
DDSIEDLGEVKK
Sequence length 198
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
DENR-related disorder Likely benign ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (87)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Amyloidosis Amyloidosis BEFREE 27677309
★★★★★
★☆☆☆☆
Found in Text Mining only
Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis BEFREE 23713734, 29335339
★★★★★
★☆☆☆☆
Found in Text Mining only
Arteriosclerosis Arteriosclerosis BEFREE 27737949
★★★★★
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis BEFREE 27737949
★★★★★
★☆☆☆☆
Found in Text Mining only
Autistic Disorder Autism BEFREE 28623304
★★★★★
★☆☆☆☆
Found in Text Mining only
Autistic Disorder Autism Pubtator 28623304, 34016977 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Brain Infarction Brain Infarction BEFREE 24758576
★★★★★
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 25434519, 25595902, 29072687, 30425235, 30809096
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 31770286
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma, Ovarian Epithelial Ovarian Epithelial carcinoma BEFREE 27509055, 31409904, 31639424
★★★★★
★☆☆☆☆
Found in Text Mining only