DENND2C (DENN domain containing 2C)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 163259
• Gene name: DENN domain containing 2C
• Gene symbol: DENND2C
• Synonyms (NCBI Gene): dJ1156J9.1
• Chromosome: 1
• Chromosome location: 1p13.2

miRNA Show/Hide all (153)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023271	hsa-miR-122-5p	Microarray	17612493
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT637069	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT671559	hsa-miR-510-3p	HITS-CLIP	23824327
MIRT672974	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT672973	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT672972	hsa-miR-603	HITS-CLIP	23824327
MIRT672971	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT672970	hsa-miR-3941	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT637069	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT671559	hsa-miR-510-3p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT637069	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT637069	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT635268	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT635267	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT637069	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT635268	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT635267	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT637069	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT635269	hsa-miR-5190	HITS-CLIP	23824327
MIRT635268	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT635267	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT635266	hsa-miR-4276	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT635268	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT635268	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT671559	hsa-miR-510-3p	HITS-CLIP	27418678
MIRT637069	hsa-miR-570-3p	HITS-CLIP	27418678
MIRT613155	hsa-miR-8485	HITS-CLIP	27418678
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT637069	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT671559	hsa-miR-510-3p	HITS-CLIP	23824327
MIRT672974	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT672973	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT672972	hsa-miR-603	HITS-CLIP	23824327
MIRT672971	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT672970	hsa-miR-3941	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT637069	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT671559	hsa-miR-510-3p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT637069	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT637069	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT635268	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT635267	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT637069	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT635268	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT635267	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT637069	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT635269	hsa-miR-5190	HITS-CLIP	23824327
MIRT635268	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT635267	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT635266	hsa-miR-4276	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT932343	hsa-miR-1224-3p	CLIP-seq
MIRT932344	hsa-miR-1260	CLIP-seq
MIRT932345	hsa-miR-1260b	CLIP-seq
MIRT932346	hsa-miR-1280	CLIP-seq
MIRT932347	hsa-miR-3674	CLIP-seq
MIRT932348	hsa-miR-371-5p	CLIP-seq
MIRT932349	hsa-miR-371b-5p	CLIP-seq
MIRT932350	hsa-miR-450b-3p	CLIP-seq
MIRT932351	hsa-miR-4713-3p	CLIP-seq
MIRT932352	hsa-miR-4726-3p	CLIP-seq
MIRT932353	hsa-miR-532-3p	CLIP-seq
MIRT932354	hsa-miR-638	CLIP-seq
MIRT932355	hsa-miR-769-3p	CLIP-seq
MIRT1976070	hsa-miR-27a	CLIP-seq
MIRT1976071	hsa-miR-27b	CLIP-seq
MIRT1976072	hsa-miR-513a-5p	CLIP-seq
MIRT1976073	hsa-miR-765	CLIP-seq
MIRT2211473	hsa-miR-1271	CLIP-seq
MIRT2211474	hsa-miR-182	CLIP-seq
MIRT1976070	hsa-miR-27a	CLIP-seq
MIRT1976071	hsa-miR-27b	CLIP-seq
MIRT2211475	hsa-miR-330-3p	CLIP-seq
MIRT1976072	hsa-miR-513a-5p	CLIP-seq
MIRT2211476	hsa-miR-9	CLIP-seq
MIRT2211477	hsa-miR-96	CLIP-seq
MIRT2679158	hsa-miR-3117-5p	CLIP-seq
MIRT2679159	hsa-miR-3138	CLIP-seq
MIRT2679160	hsa-miR-3165	CLIP-seq
MIRT2679161	hsa-miR-4717-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	20937701
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005654	Component	Nucleoplasm	IDA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q68D51
• Protein name: DENN domain-containing protein 2C
• Protein function: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02141	DENN	586 → 770	DENN (AEX-3) domain	Family
  PF03455	dDENN	847 → 895	dDENN domain	Domain
  PF03456	uDENN	510 → 578	uDENN domain	Domain

• Sequence:

  MDVGFSRTTVQTLSRSHCKNIKQKISQWEGRANGISNPEKWCPKDFGVRYNCHQEIRLKK
  NPIAERKSKNLDVTSRENVGLDINENTKSHDQSENENKKHEYDDTHFFKNESESNWVCSR
  VKEIESCKEDVLDPETSLPPGNFYTSQILWKKIEALPPDKLLNLALEHCDSSEKELNFRV
  LDSSYGITKSLENIYSEPEGQECGPSINPLPKPRRTFRYLSESGVTPYKERNCDKKYCEN
  NSCAQSSLASSQEPEPKKYGGKIRGRSKRKSFEFEDIQHFRNRNSQTIREELGRNSGSAL
  YYTQSEDNIYEDIIYPTKENPYEDIPVQPLPMWRSPSAWKLPPAKSAFKAPKLPPKPQFL
  HRKTMEVKNSQAYLRSKLTKDTTLPVTLTEWKLFRAGEVANTKRKNLPRLVLKIDDIFES
  KRGKKKVKLHSYTGKELPPTKGETSGNESDAEYLPKNRHKRLAQLQPSSKRNPHYQTLER
  DLIELQEQQLFELFVVVSLQKKPSGISYIPQVIQQFPGKDDHGYKQSKDMEERLKVIPKF
  CFPDSKDWMPTSELKSETFSFVLTGEDGSRWFGYCKKLLPVGKGKRLPEVYCMVSRLGCF
  NLFSKILDEVEKRREMSPALVYPFMRSVMEAPFPAPGRTITVKSYLPGAGDESIELCRPL
  DSRLEHVDFKCLFKCLSVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTW
  QHTYIPVLPASMIDIVCSPTPFLIGILSCSLPQLQDLPIEEVLIVDLCADKFLQEVSDED
  EILPPKLQAALMQILEERNEILTQEQNFSQDVTLNSLVSEAFVRFFVELVGHYSLNMTVT
  ERGERVFQREPFRKSHTSRSVRHFLDLFMETQMFAGFIQDRELRKSGVKGLFEIRAIQYL
  ETIPESEPSGMNRILRSLGSKMKFLQKK

• Sequence length: 928

Pathways

Reactome Pathway:

RAB GEFs exchange GTP for GDP on RABs

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	30297969	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Related Genes

No strongly related genes found yet for DENND2C.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to DENND2C.