Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	79958
Gene name	DENN domain containing 1C
Gene symbol	DENND1C
Synonyms (NCBI Gene)	FAM31C
Chromosome	19
Chromosome location	19p13.3
Summary	The protein encoded by this gene functions as a guanine nucleotide exchange factor for the early endosomal small GTPase RAB35, which regulates endosomal membrane trafficking and is involved in actin polymerization. The encoded protein activates RAB35 by p

16 Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	20937701
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006897	Process	Endocytosis	IBA
GO:0030136	Component	Clathrin-coated vesicle	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0032456	Process	Endocytic recycling	IBA
GO:0043231	Component	Intracellular membrane-bounded organelle	IBA
GO:1901981	Function	Phosphatidylinositol phosphate binding	IBA

MIM	HGNC	e!Ensembl
613634	26225	ENSG00000205744

Q8IV53

Protein name

DENN domain-containing protein 1C (Connecdenn 3) (Protein FAM31C)

Protein function

Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20154091, ECO:0000269|PubMe

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02141	DENN	90 → 293	DENN (AEX-3) domain	Family
PF03455	dDENN	357 → 408	dDENN domain	Domain
PF03456	uDENN	29 → 87	uDENN domain	Domain

Sequence

MESRAEGGSPAVFDWFFEAACPASLQEDPPILRQFPPDFRDQEAMQMVPKFCFPFDVERE
PPSPAVQHFTFALTDLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQ
DQVTEAEELLQNLFQQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDS
GRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYP
MRWEHVLIPTLPPHLLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFN
DVQALPPDVVSLLRLRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFSEE
VFLAQKPGAPLQAFHRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGALR
SYQLWADNLKKGGGALLHSVKAKTQPAVKNMYRSAKSGLKGVQSLLMYKDGDSVLQRGGS
LRAPALPSRSDRLQQRLPITQHFGKNRPLRPSRRRQLEEGTSEPPGAGTPPLSPEDEGCP
WAEEALDSSFLGSGEELDLLSEILDSLSMGAKSAGSLRPSQSLDCCHRGDLDSCFSLPNI
PRWQPDDKKLPEPEPQPLSLPSLQNASSLDATSSSKDSRSQLIPSESDQEVTSPSQSSTA
SADPSIWGDPKPSPLTEPLILHLTPSHKAAEDSTAQENPTPWLSTAPTEPSPPESPQILA
PTKPNFDIAWTSQPLDPSSDPSSLEDPRARPPKALLAERAHLQPREEPGALNSPATPTSN
CQKSQPSSRPRVADLKKCFEG

Sequence length

801

Interactions

View interactions

Reactome Pathway
RAB GEFs exchange GTP for GDP on RABs

Related Genes Genes most often co-reported with DENND1C across shared curated disease and pathway associations. 0 Download as csv Download as pdf
No strongly related genes found yet for DENND1C.

Diseases Linked via Similar Genes Diseases curated for genes most similar to DENND1C (see Related Genes above), that are NOT already directly curated for DENND1C itself -- a lead worth checking, not a confirmed association. 0 Download as csv Download as pdf
No additional diseases found yet through genes similar to DENND1C.

DENND1C (DENN domain containing 1C)

Bookmark This Gene