DEFA1B (defensin alpha 1B) | Gene Details, Disease Associations & Pathways | GeDiPNet

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Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	728358
Gene name	Defensin alpha 1B
Gene symbol	DEFA1B
Synonyms (NCBI Gene)	HNP-1HP-1HP1
Chromosome	8
Chromosome location	8p23.1
Summary	Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract,

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GO ID	Ontology	Definition	Evidence	Reference
GO:0002227	Process	Innate immune response in mucosa	IDA	12860195
GO:0005515	Function	Protein binding	IPI	32296183, 34487793
GO:0005576	Component	Extracellular region	HDA	20551380
GO:0005576	Component	Extracellular region	HDA	27559042
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	16502470
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	12860195, 21861873
GO:0005615	Component	Extracellular space	IEA
GO:0005796	Component	Golgi lumen	IEA
GO:0005796	Component	Golgi lumen	TAS
GO:0006935	Process	Chemotaxis	TAS	10914484
GO:0006952	Process	Defense response	IEA
GO:0006955	Process	Immune response	TAS	10914484
GO:0010818	Process	T cell chemotaxis	IDA	17088326
GO:0019731	Process	Antibacterial humoral response	IBA
GO:0019731	Process	Antibacterial humoral response	IDA	12860195
GO:0030520	Process	Estrogen receptor signaling pathway	IDA	21861873
GO:0031640	Process	Killing of cells of another organism	IDA	15616305, 17088326
GO:0031640	Process	Killing of cells of another organism	IEA
GO:0035578	Component	Azurophil granule lumen	TAS
GO:0042742	Process	Defense response to bacterium	IEA
GO:0042832	Process	Defense response to protozoan	IMP	17635867
GO:0045087	Process	Innate immune response	IBA
GO:0050829	Process	Defense response to Gram-negative bacterium	IBA
GO:0050830	Process	Defense response to Gram-positive bacterium	IBA
GO:0050830	Process	Defense response to Gram-positive bacterium	IDA	12860195
GO:0050832	Process	Defense response to fungus	IEA
GO:0051607	Process	Defense response to virus	IEA
GO:0051673	Process	Disruption of plasma membrane integrity in another organism	IBA
GO:0051873	Process	Killing by host of symbiont cells	IDA	17635867
GO:0061844	Process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IBA
GO:0061844	Process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IC	15616305, 17088326
GO:0061844	Process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IDA	12860195
GO:0061844	Process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IMP	17635867
GO:0070062	Component	Extracellular exosome	HDA	19199708, 23533145
GO:0140911	Function	Pore-forming activity	IBA
GO:0140911	Function	Pore-forming activity	IDA	17635867

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Interactions View interactions

KEGG Pathway	Reactome Pathway
NOD-like receptor signaling pathway	Defensins
Staphylococcus aureus infection	Alpha-defensins
Transcriptional misregulation in cancer	Neutrophil degranulation