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Gene Gene information from NCBI Gene database.
Entrez ID 57696
Gene name DEAD-box helicase 55
Gene symbol DDX55
Synonyms (NCBI Gene)
-
Chromosome 12
Chromosome location 12q24.31
Summary This gene encodes a member of protein family containing a characteristic Asp-Glu-Ala-Asp (DEAD) motif. These proteins are putative RNA helicases, and may be involved in a range of nuclear processes including translational initiation, nuclear and mitochond
miRNA miRNA information provided by mirtarbase database.
524 Show/Hide all (524)
miRTarBase ID miRNA Experiments Reference
MIRT040465 hsa-miR-615-3p CLASH 23622248
MIRT037908 hsa-miR-455-3p CLASH 23622248
MIRT510277 hsa-miR-4517 HITS-CLIP 21572407
MIRT510276 hsa-miR-5583-3p HITS-CLIP 21572407
MIRT510272 hsa-miR-369-3p HITS-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23 Show/Hide all (23)
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000470 Process Maturation of LSU-rRNA IMP 33048000
GO:0003676 Function Nucleic acid binding IEA
GO:0003723 Function RNA binding HDA 22658674
GO:0003723 Function RNA binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
620176 20085 ENSG00000111364
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8NHQ9
Protein name ATP-dependent RNA helicase DDX55 (EC 3.6.4.13) (DEAD box protein 55)
Protein function Probable ATP-binding RNA helicase. Has ATPase activity and is involved in the maturation of precursor large subunit rRNAs (PubMed:33048000).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00270 DEAD 33 → 212 DEAD/DEAH box helicase Domain
PF00271 Helicase_C 253 → 363 Helicase conserved C-terminal domain Family
PF13959 DUF4217 403 → 463 Domain of unknown function (DUF4217) Domain
Sequence
MEHVTEGSWESLPVPLHPQVLGALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKT
LAFVIPILEILLRREEKLKKSQVGAIIITPTRELAIQIDEVLSHFTKHFPEFSQILWIGG
RNPGEDVERFKQQGGNIIVATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMG
FEASINTILEFLPKQRRTGLFSATQTQEVENL
VRAGLRNPVRVSVKEKGVAASSAQKTPS
RLENYYMVCKADEKFNQLVHFLRNHKQEKHLVFFSTCACVEYYGKALEVLVKGVKIMCIH
GKMKYKRNKIFMEFRKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGRTA
RIG
HGGSALVFLLPMEESYINFLAINQKCPLQEMKPQRNTADLLPKLKSMALADRAVFEK
GMKAFVSYVQAYAKHECNLIFRLKDLDFASLARGFALLRMPKM
PELRGKQFPDFVPVDVN
TDTIPFKDKIREKQRQKLLEQQRREKTENEGRRKFIKNKAWSKQKAKKEKKKKMNEKRKR
EEGSDIEDEDMEELLNDTRLLKKLKKGKITEEEFEKGLLTTGKRTIKTVDLGISDLEDDC
Sequence length 600
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
Clear cell carcinoma of kidney Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Carcinogenesis Carcinogenesis Pubtator 35514200 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 35514200 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only