DDX28 (DEAD-box helicase 28)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 55794
• Gene name: DEAD-box helicase 28
• Gene symbol: DDX28
• Synonyms (NCBI Gene): MDDX28
• Chromosome: 16
• Chromosome location: 16q22.1
• Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and

miRNA Show/Hide all (101)

miRTarBase ID	miRNA	Experiments	Reference
MIRT032400	hsa-let-7b-5p	Proteomics	18668040
MIRT042050	hsa-miR-484	CLASH	23622248
MIRT930363	hsa-miR-224	CLIP-seq
MIRT930364	hsa-miR-23a	CLIP-seq
MIRT930365	hsa-miR-23b	CLIP-seq
MIRT930366	hsa-miR-23c	CLIP-seq
MIRT930367	hsa-miR-330-3p	CLIP-seq
MIRT930368	hsa-miR-339-5p	CLIP-seq
MIRT930369	hsa-miR-3691-3p	CLIP-seq
MIRT930370	hsa-miR-4258	CLIP-seq
MIRT930371	hsa-miR-4436b-3p	CLIP-seq
MIRT930372	hsa-miR-4537	CLIP-seq
MIRT930373	hsa-miR-4719	CLIP-seq
MIRT930363	hsa-miR-224	CLIP-seq
MIRT930367	hsa-miR-330-3p	CLIP-seq
MIRT930369	hsa-miR-3691-3p	CLIP-seq
MIRT1975406	hsa-miR-431	CLIP-seq
MIRT1975407	hsa-miR-4436b-5p	CLIP-seq
MIRT1975408	hsa-miR-4639-5p	CLIP-seq
MIRT1975409	hsa-miR-4668-3p	CLIP-seq
MIRT1975410	hsa-miR-4698	CLIP-seq
MIRT1975411	hsa-miR-4711-3p	CLIP-seq
MIRT930373	hsa-miR-4719	CLIP-seq
MIRT1975412	hsa-miR-4744	CLIP-seq
MIRT1975413	hsa-miR-520d-5p	CLIP-seq
MIRT1975414	hsa-miR-524-5p	CLIP-seq
MIRT1975415	hsa-miR-548u	CLIP-seq
MIRT1975416	hsa-miR-581	CLIP-seq
MIRT1975417	hsa-miR-592	CLIP-seq
MIRT1975418	hsa-miR-599	CLIP-seq
MIRT2210781	hsa-miR-214	CLIP-seq
MIRT930363	hsa-miR-224	CLIP-seq
MIRT2210782	hsa-miR-3156-3p	CLIP-seq
MIRT930367	hsa-miR-330-3p	CLIP-seq
MIRT2210783	hsa-miR-3619-5p	CLIP-seq
MIRT930369	hsa-miR-3691-3p	CLIP-seq
MIRT930370	hsa-miR-4258	CLIP-seq
MIRT2210784	hsa-miR-4291	CLIP-seq
MIRT2210785	hsa-miR-4301	CLIP-seq
MIRT1975406	hsa-miR-431	CLIP-seq
MIRT2210786	hsa-miR-4435	CLIP-seq
MIRT930371	hsa-miR-4436b-3p	CLIP-seq
MIRT1975407	hsa-miR-4436b-5p	CLIP-seq
MIRT2210787	hsa-miR-4530	CLIP-seq
MIRT930372	hsa-miR-4537	CLIP-seq
MIRT1975408	hsa-miR-4639-5p	CLIP-seq
MIRT2210788	hsa-miR-4659a-3p	CLIP-seq
MIRT2210789	hsa-miR-4659b-3p	CLIP-seq
MIRT1975409	hsa-miR-4668-3p	CLIP-seq
MIRT2210790	hsa-miR-4690-3p	CLIP-seq
MIRT1975410	hsa-miR-4698	CLIP-seq
MIRT1975411	hsa-miR-4711-3p	CLIP-seq
MIRT930373	hsa-miR-4719	CLIP-seq
MIRT1975412	hsa-miR-4744	CLIP-seq
MIRT2210791	hsa-miR-4778-3p	CLIP-seq
MIRT2210792	hsa-miR-503	CLIP-seq
MIRT2210793	hsa-miR-515-5p	CLIP-seq
MIRT1975413	hsa-miR-520d-5p	CLIP-seq
MIRT1975414	hsa-miR-524-5p	CLIP-seq
MIRT2210794	hsa-miR-532-3p	CLIP-seq
MIRT1975415	hsa-miR-548u	CLIP-seq
MIRT1975416	hsa-miR-581	CLIP-seq
MIRT1975417	hsa-miR-592	CLIP-seq
MIRT1975418	hsa-miR-599	CLIP-seq
MIRT2210795	hsa-miR-646	CLIP-seq
MIRT2210796	hsa-miR-761	CLIP-seq
MIRT2210797	hsa-miR-922	CLIP-seq
MIRT2210798	hsa-miR-942	CLIP-seq
MIRT2210781	hsa-miR-214	CLIP-seq
MIRT2514757	hsa-miR-3153	CLIP-seq
MIRT930368	hsa-miR-339-5p	CLIP-seq
MIRT2210783	hsa-miR-3619-5p	CLIP-seq
MIRT2210784	hsa-miR-4291	CLIP-seq
MIRT1975406	hsa-miR-431	CLIP-seq
MIRT1975407	hsa-miR-4436b-5p	CLIP-seq
MIRT1975408	hsa-miR-4639-5p	CLIP-seq
MIRT2514758	hsa-miR-4646-5p	CLIP-seq
MIRT2210788	hsa-miR-4659a-3p	CLIP-seq
MIRT2210789	hsa-miR-4659b-3p	CLIP-seq
MIRT1975409	hsa-miR-4668-3p	CLIP-seq
MIRT2514759	hsa-miR-4668-5p	CLIP-seq
MIRT1975410	hsa-miR-4698	CLIP-seq
MIRT1975411	hsa-miR-4711-3p	CLIP-seq
MIRT1975412	hsa-miR-4744	CLIP-seq
MIRT2210791	hsa-miR-4778-3p	CLIP-seq
MIRT2210793	hsa-miR-515-5p	CLIP-seq
MIRT1975413	hsa-miR-520d-5p	CLIP-seq
MIRT1975414	hsa-miR-524-5p	CLIP-seq
MIRT1975415	hsa-miR-548u	CLIP-seq
MIRT1975416	hsa-miR-581	CLIP-seq
MIRT1975417	hsa-miR-592	CLIP-seq
MIRT2514760	hsa-miR-595	CLIP-seq
MIRT1975418	hsa-miR-599	CLIP-seq
MIRT2210795	hsa-miR-646	CLIP-seq
MIRT2210796	hsa-miR-761	CLIP-seq
MIRT2210797	hsa-miR-922	CLIP-seq
MIRT2210798	hsa-miR-942	CLIP-seq
MIRT2514757	hsa-miR-3153	CLIP-seq
MIRT2514758	hsa-miR-4646-5p	CLIP-seq
MIRT2514759	hsa-miR-4668-5p	CLIP-seq
MIRT2514760	hsa-miR-595	CLIP-seq

Gene ontology (GO) Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0003724	Function	RNA helicase activity	IEA
GO:0004386	Function	Helicase activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005829	Component	Cytosol	IDA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0019843	Function	RRNA binding	IDA	25683715
GO:0019843	Function	RRNA binding	IEA
GO:0035770	Component	Ribonucleoprotein granule	IDA	25683715
GO:0042254	Process	Ribosome biogenesis	IEA
GO:0042645	Component	Mitochondrial nucleoid	IDA	18063578, 25683715
GO:0042645	Component	Mitochondrial nucleoid	IEA
GO:1902775	Process	Mitochondrial large ribosomal subunit assembly	IBA
GO:1902775	Process	Mitochondrial large ribosomal subunit assembly	IMP	25683715

Other IDs

• MIM: 607618
• HGNC: 17330
• e!Ensembl: ENSG00000182810

Protein

• UniProt ID: Q9NUL7
• Protein name: Probable ATP-dependent RNA helicase DDX28 (EC 3.6.4.13) (Mitochondrial DEAD box protein 28)
• Protein function: Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function (PubMed:25683708, PubMed:25683715). May be involved in RNA processing or transport.
• PDB: 7OI6
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00270	DEAD	152 → 340	DEAD/DEAH box helicase	Domain
  PF00271	Helicase_C	376 → 492	Helicase conserved C-terminal domain	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in all tissues tested, including brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, leukocytes, colon, small intestine, ovary and prostate. {ECO:0000269|PubMed:11350955}.
• Sequence:

  MALTRPVRLFSLVTRLLLAPRRGLTVRSPDEPLPVVRIPVALQRQLEQRQSRRRNLPRPV
  LVRPGPLLVSARRPELNQPARLTLGRWERAPLASQGWKSRRARRDHFSIERAQQEAPAVR
  KLSSKGSFADLGLEPRVLHALQEAAPEVVQPTTVQSSTIPSLLRGRHVVCAAETGSGKTL
  SYLLPLLQRLLGQPSLDSLPIPAPRGLVLVPSRELAQQVRAVAQPLGRSLGLLVRDLEGG
  HGMRRIRLQLSRQPSADVLVATPGALWKALKSRLISLEQLSFLVLDEADTLLDESFLELV
  DYILEKSHIAEGPADLEDPFNPKAQLVLVGATFPEGVGQLLNKVASPDAVTTITSSKLHC
  IMPHVKQTFLRLKGADKVAELVHILKHRDRAERTGPSGTVLVFCNSSSTVNWLGYILDDH
  KIQHLRLQGQMPALMRVGIFQSFQKSSRDILLCTDIASRGLDSTGVELVVNYDFPPTLQD
  YIHRAGRVGRVGSEVPGTVISFVTHPWDVSLVQKIELAARRRRSLPGLASSVKEPLPQAT
  

• Sequence length: 540

Related Genes

No strongly related genes found yet for DDX28.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to DDX28.