DDX24 (DEAD-box helicase 24)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 57062
• Gene name: DEAD-box helicase 24
• Gene symbol: DDX24
• Synonyms (NCBI Gene): -
• Chromosome: 14
• Chromosome location: 14q32.12
• Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and m

miRNA Show/Hide all (123)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025483	hsa-miR-34a-5p	Proteomics	21566225
MIRT039208	hsa-miR-769-5p	CLASH	23622248
MIRT038160	hsa-miR-423-5p	CLASH	23622248
MIRT037975	hsa-miR-505-5p	CLASH	23622248
MIRT037565	hsa-miR-744-5p	CLASH	23622248
MIRT930323	hsa-miR-122	CLIP-seq
MIRT930324	hsa-miR-141	CLIP-seq
MIRT930325	hsa-miR-200a	CLIP-seq
MIRT930326	hsa-miR-3145-5p	CLIP-seq
MIRT930327	hsa-miR-3165	CLIP-seq
MIRT930328	hsa-miR-3170	CLIP-seq
MIRT930329	hsa-miR-320e	CLIP-seq
MIRT930330	hsa-miR-323-5p	CLIP-seq
MIRT930331	hsa-miR-33a	CLIP-seq
MIRT930332	hsa-miR-33b	CLIP-seq
MIRT930333	hsa-miR-3944-5p	CLIP-seq
MIRT930334	hsa-miR-4420	CLIP-seq
MIRT930335	hsa-miR-4452	CLIP-seq
MIRT930336	hsa-miR-4457	CLIP-seq
MIRT930337	hsa-miR-4704-3p	CLIP-seq
MIRT930338	hsa-miR-4731-3p	CLIP-seq
MIRT930339	hsa-miR-4762-5p	CLIP-seq
MIRT930340	hsa-miR-4801	CLIP-seq
MIRT930341	hsa-miR-494	CLIP-seq
MIRT930342	hsa-miR-508-5p	CLIP-seq
MIRT930343	hsa-miR-550b	CLIP-seq
MIRT930344	hsa-miR-603	CLIP-seq
MIRT930345	hsa-miR-619	CLIP-seq
MIRT930346	hsa-miR-642b	CLIP-seq
MIRT930347	hsa-miR-876-3p	CLIP-seq
MIRT930324	hsa-miR-141	CLIP-seq
MIRT930325	hsa-miR-200a	CLIP-seq
MIRT930329	hsa-miR-320e	CLIP-seq
MIRT930333	hsa-miR-3944-5p	CLIP-seq
MIRT930334	hsa-miR-4420	CLIP-seq
MIRT930337	hsa-miR-4704-3p	CLIP-seq
MIRT930344	hsa-miR-603	CLIP-seq
MIRT930346	hsa-miR-642b	CLIP-seq
MIRT2210767	hsa-miR-3115	CLIP-seq
MIRT930327	hsa-miR-3165	CLIP-seq
MIRT930328	hsa-miR-3170	CLIP-seq
MIRT930330	hsa-miR-323-5p	CLIP-seq
MIRT2210768	hsa-miR-4455	CLIP-seq
MIRT2210769	hsa-miR-4481	CLIP-seq
MIRT930338	hsa-miR-4731-3p	CLIP-seq
MIRT2210770	hsa-miR-4745-5p	CLIP-seq
MIRT2210771	hsa-miR-4758-5p	CLIP-seq
MIRT930339	hsa-miR-4762-5p	CLIP-seq
MIRT930340	hsa-miR-4801	CLIP-seq
MIRT930341	hsa-miR-494	CLIP-seq
MIRT2210772	hsa-miR-609	CLIP-seq
MIRT930345	hsa-miR-619	CLIP-seq
MIRT930347	hsa-miR-876-3p	CLIP-seq
MIRT2210767	hsa-miR-3115	CLIP-seq
MIRT2210768	hsa-miR-4455	CLIP-seq
MIRT2210769	hsa-miR-4481	CLIP-seq
MIRT2210770	hsa-miR-4745-5p	CLIP-seq
MIRT2210771	hsa-miR-4758-5p	CLIP-seq
MIRT2210772	hsa-miR-609	CLIP-seq
MIRT930336	hsa-miR-4457	CLIP-seq
MIRT2436795	hsa-miR-450b-5p	CLIP-seq
MIRT930338	hsa-miR-4731-3p	CLIP-seq
MIRT930340	hsa-miR-4801	CLIP-seq
MIRT930341	hsa-miR-494	CLIP-seq
MIRT2436796	hsa-miR-507	CLIP-seq
MIRT2436797	hsa-miR-518a-5p	CLIP-seq
MIRT2436798	hsa-miR-527	CLIP-seq
MIRT2436799	hsa-miR-557	CLIP-seq
MIRT930336	hsa-miR-4457	CLIP-seq
MIRT2436795	hsa-miR-450b-5p	CLIP-seq
MIRT930338	hsa-miR-4731-3p	CLIP-seq
MIRT930340	hsa-miR-4801	CLIP-seq
MIRT930341	hsa-miR-494	CLIP-seq
MIRT2436796	hsa-miR-507	CLIP-seq
MIRT2436797	hsa-miR-518a-5p	CLIP-seq
MIRT2436798	hsa-miR-527	CLIP-seq
MIRT2436799	hsa-miR-557	CLIP-seq
MIRT930323	hsa-miR-122	CLIP-seq
MIRT930327	hsa-miR-3165	CLIP-seq
MIRT930328	hsa-miR-3170	CLIP-seq
MIRT930330	hsa-miR-323-5p	CLIP-seq
MIRT2514745	hsa-miR-3919	CLIP-seq
MIRT2514746	hsa-miR-3925-5p	CLIP-seq
MIRT930333	hsa-miR-3944-5p	CLIP-seq
MIRT930334	hsa-miR-4420	CLIP-seq
MIRT930336	hsa-miR-4457	CLIP-seq
MIRT2436795	hsa-miR-450b-5p	CLIP-seq
MIRT2514747	hsa-miR-4676-5p	CLIP-seq
MIRT930337	hsa-miR-4704-3p	CLIP-seq
MIRT930338	hsa-miR-4731-3p	CLIP-seq
MIRT2514748	hsa-miR-4773	CLIP-seq
MIRT930340	hsa-miR-4801	CLIP-seq
MIRT930341	hsa-miR-494	CLIP-seq
MIRT2436796	hsa-miR-507	CLIP-seq
MIRT2436797	hsa-miR-518a-5p	CLIP-seq
MIRT2436798	hsa-miR-527	CLIP-seq
MIRT2436799	hsa-miR-557	CLIP-seq
MIRT2514749	hsa-miR-575	CLIP-seq
MIRT930345	hsa-miR-619	CLIP-seq
MIRT930347	hsa-miR-876-3p	CLIP-seq
MIRT930323	hsa-miR-122	CLIP-seq
MIRT930327	hsa-miR-3165	CLIP-seq
MIRT930328	hsa-miR-3170	CLIP-seq
MIRT930330	hsa-miR-323-5p	CLIP-seq
MIRT2514745	hsa-miR-3919	CLIP-seq
MIRT2514746	hsa-miR-3925-5p	CLIP-seq
MIRT930333	hsa-miR-3944-5p	CLIP-seq
MIRT930334	hsa-miR-4420	CLIP-seq
MIRT930336	hsa-miR-4457	CLIP-seq
MIRT2436795	hsa-miR-450b-5p	CLIP-seq
MIRT2514747	hsa-miR-4676-5p	CLIP-seq
MIRT930337	hsa-miR-4704-3p	CLIP-seq
MIRT930338	hsa-miR-4731-3p	CLIP-seq
MIRT2514748	hsa-miR-4773	CLIP-seq
MIRT930340	hsa-miR-4801	CLIP-seq
MIRT930341	hsa-miR-494	CLIP-seq
MIRT2436796	hsa-miR-507	CLIP-seq
MIRT2436797	hsa-miR-518a-5p	CLIP-seq
MIRT2436798	hsa-miR-527	CLIP-seq
MIRT2436799	hsa-miR-557	CLIP-seq
MIRT2514749	hsa-miR-575	CLIP-seq
MIRT930345	hsa-miR-619	CLIP-seq
MIRT930347	hsa-miR-876-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0003724	Function	RNA helicase activity	IEA
GO:0003724	Function	RNA helicase activity	NAS	10936056
GO:0004386	Function	Helicase activity	IEA
GO:0005515	Function	Protein binding	IPI	22113938, 32707033, 35271311
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016070	Process	RNA metabolic process	NAS	10936056
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA

Other IDs

• MIM: 606181
• HGNC: 13266
• e!Ensembl: ENSG00000089737

Protein

• UniProt ID: Q9GZR7
• Protein name: ATP-dependent RNA helicase DDX24 (EC 3.6.4.13) (DEAD box protein 24)
• Protein function: ATP-dependent RNA helicase that plays a role in various aspects of RNA metabolism including pre-mRNA splicing and is thereby involved in different biological processes such as cell cycle regulation or innate immunity (PubMed:24204270, PubMed:249
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00270	DEAD	216 → 516	DEAD/DEAH box helicase	Domain
  PF00271	Helicase_C	574 → 682	Helicase conserved C-terminal domain	Family

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous. Most abundant in heart and brain, but with lowest levels in thymus and small intestine.
• Sequence:

  MKLKDTKSRPKQSSCGKFQTKGIKVVGKWKEVKIDPNMFADGQMDDLVCFEELTDYQLVS
  PAKNPSSLFSKEAPKRKAQAVSEEEEEEEGKSSSPKKKIKLKKSKNVATEGTSTQKEFEV
  KDPELEAQGDDMVCDDPEAGEMTSENLVQTAPKKKKNKGKKGLEPSQSTAAKVPKKAKTW
  IPEVHDQKADVSAWKDLFVPRPVLRALSFLGFSAPTPIQALTLAPAIRDKLDILGAAETG
  SGKTLAFAIPMIHAVLQWQKRNAAPPPSNTEAPPGETRTEAGAETRSPGKAEAESDALPD
  DTVIESEALPSDIAAEARAKTGGTVSDQALLFGDDDAGEGPSSLIREKPVPKQNENEEEN
  LDKEQTGNLKQELDDKSATCKAYPKRPLLGLVLTPTRELAVQVKQHIDAVARFTGIKTAI
  LVGGMSTQKQQRMLNRRPEIVVATPGRLWELIKEKHYHLRNLRQLRCLVVDEADRMVEKG
  HFAELSQLLEMLNDSQYNPKRQTLVFSATLTLVHQAPARILHKKHTKKMDKTAKLDLLMQ
  KIGMRGKPKVIDLTRNEATVETLTETKIHCETDEKDFYLYYFLMQYPGRSLVFANSISCI
  KRLSGLLKVLDIMPLTLHACMHQKQRLRNLEQFARLEDCVLLATDVAARGLDIPKVQHVI
  HYQVPRTSEIYVHRSGRTARATNEGLSLMLIGPEDVINFKKIYKTLKKDEDIPLFPVQTK
  YMDVVKERIRLARQIEKSEYRNFQACLHNSWIEQAAAALEIELEEDMYKGGKADQQEERR
  RQKQMKVLKKELRHLLSQPLFTESQKTKYPTQSGKPPLLVSAPSKSESALSCLSKQKKKK
  TKKPKEPQPEQPQPSTSAN

• Sequence length: 859

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Malignant tumor of esophagus	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (6)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	36310384, 36335087	Associate	★☆☆☆☆ Found in Text Mining only
Cerebral Hemorrhage	Cerebral hemorrhage	Pubtator	30836997	Associate	★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple sclerosis	Pubtator	31805175	Associate	★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	33754909	Associate	★☆☆☆☆ Found in Text Mining only
Sarcoma Kaposi	Sarcoma	Pubtator	36298642	Inhibit	★☆☆☆☆ Found in Text Mining only
Vascular Malformations	Vascular malformation	Pubtator	30063812, 37705750	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for DDX24.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to DDX24.