DDX12P (DEAD/H-box helicase 12, pseudogene)

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Gene Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 440081
• Gene name: DEAD/H-box helicase 12, pseudogene
• Gene symbol: DDX12P
• Synonyms (NCBI Gene): CHLR2, DDX12
• Chromosome: 12
• Chromosome location: 12p13.31

Gene ontology (GO) Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003678	Function	DNA helicase activity	IBA
GO:0003678	Function	DNA helicase activity	IEA
GO:0003723	Function	RNA binding	IEA
GO:0003724	Function	RNA helicase activity	IEA
GO:0004386	Function	Helicase activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006139	Process	Nucleobase-containing compound metabolic process	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016818	Function	Hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IEA
GO:0016853	Function	Isomerase activity	IEA
GO:0034085	Process	Establishment of sister chromatid cohesion	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0051536	Function	Iron-sulfur cluster binding	IEA

Other IDs

• MIM: 601151
• HGNC: 2737
• e!Ensembl: HGNC

Protein

• UniProt ID: Q92771
• Protein name: Putative ATP-dependent DNA helicase DDX12 (EC 5.6.2.-) (CHL1-related protein 2) (hCHLR2) (DEAD/H box protein 12)
• Protein function: DNA helicase involved in cellular proliferation. Probably required for maintaining the chromosome segregation (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06733	DEAD_2	250 → 434	DEAD_2	Family
  PF13307	Helicase_C_2	711 → 900	Helicase C-terminal domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Only transcribed in proliferating tissues; the probe used detects both DDX11 and DDX12P. {ECO:0000269|PubMed:9013641}.
• Sequence:

  MRSGGGCSGSLSLRGPASFKFSGVCPDSRGLAFSVAILPAKKEDFMAELYRVLEAGKIGI
  FESPTGTGKSLSLICGALSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGA
  AGTPRPAGEPAWVTQFVQKKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLR
  QEEEERENLLRLSREMLETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDL
  EEEHITKIYHCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLI
  NNRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLL
  ALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDT
  TTSMHSVEVSGSQLCQAHSQLLQYMERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQ
  NPNTQSLSQTGMELKTINDFLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSS
  REQPKLAGFQQFLQSLQPRTTEALAAPADESQASVPQPASPLMHIEGFLAALTTANQDGR
  VILSRQGSLSQSTLKFLLLNPAVHFAQVVKECRAVVIAGGTMQPVSNFRQQLLACAGVEA
  ERVVEFSCGHVIPPDNILPLVICSGVSNQPLEFTFQKRDLPQMMDEVGRILCNLCGVVSG
  GVVCFFPSYEYLRQVHAHWEKGGLLGRLAARKKIFQEPKSAHQVEQVLLAYSRCLQACGQ
  ERGPVTGALLLSVVGGKMSEGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPR
  APGQAHPGKALVENLCMKAVNQSIGRAIRHQKDFASIVLLDQRYARPPVLAKLPAWIRAR
  VEVKATFGPAIAAVQKVSPTFFFLRASQPRDHISHCLLSAQFHREKSASS

• Sequence length: 950

Related Genes

No strongly related genes found yet for DDX12P.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to DDX12P.