DDT (D-dopachrome tautomerase)

Download as csv Download as pdf

Log in to save this analysis

Save This Analysis

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Diseases linked via similar genes

Gene

• Entrez ID: 1652
• Gene name: D-dopachrome tautomerase
• Gene symbol: DDT
• Synonyms (NCBI Gene): D-DT, DDCT, MIF-2, MIF2
• Chromosome: 22
• Chromosome location: 22q11.23
• Summary: D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22. [provided

miRNA Show/Hide all (77)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024080	hsa-miR-1-3p	Proteomics	18668040
MIRT045554	hsa-miR-149-5p	CLASH	23622248
MIRT037798	hsa-miR-92b-5p	CLASH	23622248
MIRT036520	hsa-miR-1226-3p	CLASH	23622248
MIRT454042	hsa-miR-5197-3p	PAR-CLIP	23592263
MIRT454041	hsa-miR-3159	PAR-CLIP	23592263
MIRT454040	hsa-miR-4501	PAR-CLIP	23592263
MIRT454039	hsa-miR-205-3p	PAR-CLIP	23592263
MIRT454038	hsa-miR-3185	PAR-CLIP	23592263
MIRT454037	hsa-miR-1185-5p	PAR-CLIP	23592263
MIRT454036	hsa-miR-3679-5p	PAR-CLIP	23592263
MIRT454035	hsa-miR-3605-5p	PAR-CLIP	23592263
MIRT454034	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT454033	hsa-miR-5007-3p	PAR-CLIP	23592263
MIRT454042	hsa-miR-5197-3p	PAR-CLIP	23592263
MIRT454041	hsa-miR-3159	PAR-CLIP	23592263
MIRT454040	hsa-miR-4501	PAR-CLIP	23592263
MIRT454039	hsa-miR-205-3p	PAR-CLIP	23592263
MIRT454038	hsa-miR-3185	PAR-CLIP	23592263
MIRT454037	hsa-miR-1185-5p	PAR-CLIP	23592263
MIRT454036	hsa-miR-3679-5p	PAR-CLIP	23592263
MIRT454035	hsa-miR-3605-5p	PAR-CLIP	23592263
MIRT454034	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT454033	hsa-miR-5007-3p	PAR-CLIP	23592263
MIRT929570	hsa-miR-1299	CLIP-seq
MIRT929571	hsa-miR-27a	CLIP-seq
MIRT929572	hsa-miR-27b	CLIP-seq
MIRT929573	hsa-miR-320a	CLIP-seq
MIRT929574	hsa-miR-320b	CLIP-seq
MIRT929575	hsa-miR-320c	CLIP-seq
MIRT929576	hsa-miR-320d	CLIP-seq
MIRT929577	hsa-miR-320e	CLIP-seq
MIRT929578	hsa-miR-326	CLIP-seq
MIRT929579	hsa-miR-330-5p	CLIP-seq
MIRT929580	hsa-miR-3925-3p	CLIP-seq
MIRT929581	hsa-miR-409-3p	CLIP-seq
MIRT929582	hsa-miR-4429	CLIP-seq
MIRT929583	hsa-miR-4480	CLIP-seq
MIRT929584	hsa-miR-4639-3p	CLIP-seq
MIRT929585	hsa-miR-4645-5p	CLIP-seq
MIRT929586	hsa-miR-4673	CLIP-seq
MIRT929587	hsa-miR-4676-5p	CLIP-seq
MIRT929588	hsa-miR-4684-3p	CLIP-seq
MIRT929589	hsa-miR-4727-5p	CLIP-seq
MIRT929590	hsa-miR-4769-3p	CLIP-seq
MIRT929591	hsa-miR-575	CLIP-seq
MIRT929592	hsa-miR-7	CLIP-seq
MIRT929593	hsa-miR-766	CLIP-seq
MIRT929594	hsa-miR-875-3p	CLIP-seq
MIRT929571	hsa-miR-27a	CLIP-seq
MIRT929572	hsa-miR-27b	CLIP-seq
MIRT929587	hsa-miR-4676-5p	CLIP-seq
MIRT929591	hsa-miR-575	CLIP-seq
MIRT929570	hsa-miR-1299	CLIP-seq
MIRT929587	hsa-miR-4676-5p	CLIP-seq
MIRT929591	hsa-miR-575	CLIP-seq
MIRT929592	hsa-miR-7	CLIP-seq
MIRT929594	hsa-miR-875-3p	CLIP-seq
MIRT2210627	hsa-miR-1	CLIP-seq
MIRT2210628	hsa-miR-146b-3p	CLIP-seq
MIRT2210629	hsa-miR-206	CLIP-seq
MIRT929571	hsa-miR-27a	CLIP-seq
MIRT929572	hsa-miR-27b	CLIP-seq
MIRT2210630	hsa-miR-3173-5p	CLIP-seq
MIRT929573	hsa-miR-320a	CLIP-seq
MIRT929574	hsa-miR-320b	CLIP-seq
MIRT929575	hsa-miR-320c	CLIP-seq
MIRT929576	hsa-miR-320d	CLIP-seq
MIRT929577	hsa-miR-320e	CLIP-seq
MIRT929581	hsa-miR-409-3p	CLIP-seq
MIRT2210631	hsa-miR-4308	CLIP-seq
MIRT929582	hsa-miR-4429	CLIP-seq
MIRT929587	hsa-miR-4676-5p	CLIP-seq
MIRT929588	hsa-miR-4684-3p	CLIP-seq
MIRT929591	hsa-miR-575	CLIP-seq
MIRT2210632	hsa-miR-613	CLIP-seq
MIRT2210633	hsa-miR-874	CLIP-seq

Gene ontology (GO) Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004167	Function	Dopachrome isomerase activity	TAS	9480844
GO:0005126	Function	Cytokine receptor binding	IDA	21817065
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	21817065
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	8267597
GO:0010760	Process	Negative regulation of macrophage chemotaxis	IDA	21817065
GO:0016829	Function	Lyase activity	IEA
GO:0032760	Process	Positive regulation of tumor necrosis factor production	IDA	21817065
GO:0033981	Function	D-dopachrome decarboxylase activity	IDA	8267597
GO:0033981	Function	D-dopachrome decarboxylase activity	IEA
GO:0033981	Function	D-dopachrome decarboxylase activity	IMP	9480844
GO:0042438	Process	Melanin biosynthetic process	IEA
GO:0050178	Function	Phenylpyruvate tautomerase activity	IBA
GO:0050178	Function	Phenylpyruvate tautomerase activity	IDA	21817065
GO:0050729	Process	Positive regulation of inflammatory response	IC	21817065
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IGI	21817065

Other IDs

• MIM: 602750
• HGNC: 2732
• e!Ensembl: ENSG00000099977

Protein

• UniProt ID: P30046
• Protein name: D-dopachrome decarboxylase (EC 4.1.1.84) (D-dopachrome tautomerase) (Phenylpyruvate tautomerase II)
• Protein function: Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).
• PDB: 1DPT , 3KAN , 4Q3F , 6C5F , 7MRU , 7MRV , 7MSE , 7MW7 , 8DBB , 8VDY , 8VFK , 8VFL , 8VFN , 8VFO , 8VFW , 8VG5 , 8VG7 , 8VG8 , 9BB0
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01187	MIF	2 → 116	Macrophage migration inhibitory factor (MIF)	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in the liver and at lower levels in the heart, lung and pancreas. {ECO:0000269|PubMed:8267597, ECO:0000269|PubMed:9480844}.
• Sequence:

  MPFLELDTNLPANRVPAGLEKRLCAAAASILGKPADRVNVTVRPGLAMALSGSTEPCAQL
  SISSIGVVGTAEDNRSHSAHFFEFLTKELALGQDRILIRFFPLESWQIGKIGTVMTFL

• Sequence length: 118

Related Genes

No strongly related genes found yet for DDT.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to DDT.