Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	220042
Gene name	DNA damage induced apoptosis suppressor
Gene symbol	DDIAS
Synonyms (NCBI Gene)	C11orf82noxin
Chromosome	11
Chromosome location	11q14.1

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miRTarBase ID	miRNA	Experiments	Reference
MIRT755021	hsa-miR-526b-3p	PAR-CLIP	23592263
MIRT755022	hsa-miR-519d-3p	PAR-CLIP	23592263
MIRT755023	hsa-miR-20b-5p	PAR-CLIP	23592263
MIRT755024	hsa-miR-20a-5p	PAR-CLIP	23592263
MIRT755025	hsa-miR-17-5p	PAR-CLIP	23592263
MIRT755026	hsa-miR-106a-5p	PAR-CLIP	23592263
MIRT755027	hsa-miR-106b-5p	PAR-CLIP	23592263
MIRT755028	hsa-miR-93-5p	PAR-CLIP	23592263
MIRT755029	hsa-miR-548av-5p	PAR-CLIP	23592263
MIRT755030	hsa-miR-548k	PAR-CLIP	23592263
MIRT755031	hsa-miR-8054	PAR-CLIP	23592263
MIRT755032	hsa-miR-3609	PAR-CLIP	23592263
MIRT755033	hsa-miR-548ah-5p	PAR-CLIP	23592263
MIRT755034	hsa-miR-4796-3p	PAR-CLIP	23592263
MIRT755035	hsa-miR-4662a-3p	PAR-CLIP	23592263
MIRT755036	hsa-miR-302a-3p	PAR-CLIP	23592263
MIRT755037	hsa-miR-302b-3p	PAR-CLIP	23592263
MIRT755038	hsa-miR-302c-3p	PAR-CLIP	23592263
MIRT755039	hsa-miR-302d-3p	PAR-CLIP	23592263
MIRT755040	hsa-miR-302e	PAR-CLIP	23592263
MIRT755041	hsa-miR-372-3p	PAR-CLIP	23592263
MIRT755042	hsa-miR-373-3p	PAR-CLIP	23592263
MIRT755043	hsa-miR-520a-3p	PAR-CLIP	23592263
MIRT755044	hsa-miR-520b	PAR-CLIP	23592263
MIRT755045	hsa-miR-520c-3p	PAR-CLIP	23592263
MIRT755046	hsa-miR-520d-3p	PAR-CLIP	23592263
MIRT755047	hsa-miR-520e	PAR-CLIP	23592263
MIRT755048	hsa-miR-338-5p	PAR-CLIP	23592263
MIRT755049	hsa-miR-144-3p	PAR-CLIP	23592263
MIRT755050	hsa-miR-577	PAR-CLIP	23592263
MIRT755051	hsa-miR-142-5p	PAR-CLIP	23592263
MIRT755052	hsa-miR-5590-3p	PAR-CLIP	23592263
MIRT755053	hsa-miR-95-5p	PAR-CLIP	23592263
MIRT755054	hsa-miR-7158-5p	PAR-CLIP	23592263

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0051726	Process	Regulation of cell cycle	IEA
GO:0097752	Process	Regulation of DNA stability	IMP	24214091
GO:1902230	Process	Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IEA
GO:1902230	Process	Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IMP	24214091

MIM	HGNC	e!Ensembl
618045	26351	ENSG00000165490

Q8IXT1

Protein name

DNA damage-induced apoptosis suppressor protein (Nitric oxide-inducible gene protein)

Protein function

May be an anti-apoptotic protein involved in DNA repair or cell survival.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08646	Rep_fac-A_C	7 → 122	Replication factor-A C terminal domain	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in colorectal and lung cancer tissues. {ECO:0000269|PubMed:24214091}.

Sequence

MNRRRKFLLASVLALQNSSFIYPSCQKCFSRIILVSKRSNCPKCGSTGESGNANYRYKLS
LKVAESNKLFVITVFGSCLDTFFGLTATGLHRYIQDPNKIPETLDNDTTQNLLTKAVETC
FVGQSFIFGVTNFENQPGQGSDASNFLQQCSDHKRKAKALVACQIVLPDPGIAGFTVIDY
FHQLLQTFNFRKLQCDSQAPNNHLLALDHSNSDLSSIYTSDSTSDFFKSCSKDTFSKFWQ
PSLEFTCIVSQLTDNDDFSASEQSKAFGTLQQNRKSISIAEATGSSSCHDPIQDSWSLVS
YMDKKSTAEKLGKELGLQAKELSAVHSSHHEIGVNDSNLFSLEMREPLESSNTKSFHSAV
EIKNRSQHELPCFQHHGIDTPTSLQKRSACCPPSLLRLEETASSSQDGDPQIWDDLPFSE
SLNKFLAVLESEIAVTQADVSSRKHHVDNDIDKFHADHSRLSVTPQRTTGALHTPPIALR
SSQVIVKANCSKDDFLFNCKGNLSPSVEKESQPDNKVEAVSVNHNGRDMSEYFLPNPYLS
ALSSSSKDLETIVTLKKTIRISPHRESDHSSLNNKYLNGCGEISVSEMNEKLTTLCYRKY
NDVSDLCKLENKQYCRWSKNQDDSFTICRKLTYPLETLCNSPNRSTNTLKEMPWGHINNN
VTQSYSIGYEGSYDASADLFDDIAKEMDIATEITKKSQDILLKWGTSLAESHPSESDFSL
RSLSEDFIQPSQKLSLQSLSDSRHSRTCSPTPHFQSDSEYNFENSQDFVPCSQSTPISGF
HQTRIHGINRAFKKPVFYSDLDGNYEKIRIFPENDKQQASPSCPKNIKTPSQKIRSPIVS
GVSQPDVFNHYPFAECHETDSDEWVPPTTQKIFPSDMLGFQGIGLGKCLAAYHFPDQQEL
PRKKLKHIRQGTNKGLIKKKLKNMLAAVVTKKKTHKYNCKSSGWISKCPDIQVLAAPQLH
PILGPDSCSEVKCCLPFSEKGPPSVCETRSAWSPELFS

Sequence length

998

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Lung cancer	Uncertain significance	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	23251661	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (11)
Breast Carcinoma	Breast Carcinoma	BEFREE	23581225		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	28618963	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	24214091, 26493727, 28079882, 29242605		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	25612832, 29242605		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	BEFREE	26493727		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	28079882	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	28618963	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	23581225		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	24214091, 26493727, 28079882, 29242605		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28079882, 29242605		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	29242605		★★★★★ ★☆☆☆☆ Found in Text Mining only

Related Genes Genes most often co-reported with DDIAS across shared curated disease and pathway associations. 0 Download as csv Download as pdf
No strongly related genes found yet for DDIAS.

Diseases Linked via Similar Genes Diseases curated for genes most similar to DDIAS (see Related Genes above), that are NOT already directly curated for DDIAS itself -- a lead worth checking, not a confirmed association. 0 Download as csv Download as pdf
No additional diseases found yet through genes similar to DDIAS.

DDIAS (DNA damage induced apoptosis suppressor)

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