DCTPP1 (dCTP pyrophosphatase 1)

Download as csv Download as pdf

Log in to save this analysis

Save This Analysis

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 79077
• Gene name: DCTP pyrophosphatase 1
• Gene symbol: DCTPP1
• Synonyms (NCBI Gene): CDA03, RS21C6, XTP3TPA
• Chromosome: 16
• Chromosome location: 16p11.2
• Summary: The protein encoded by this gene is dCTP pyrophosphatase, which converts dCTP to dCMP and inorganic pyrophosphate. The encoded protein also displays weak activity against dTTP and dATP, but none against dGTP. This protein may be responsible for eliminatin

miRNA Show/Hide all (196)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005221	hsa-let-7b-5p	pSILAC	18668040
MIRT023878	hsa-miR-1-3p	Proteomics	18668040
MIRT025514	hsa-miR-34a-5p	Proteomics	21566225
MIRT025514	hsa-miR-34a-5p	Proteomics	21566225
MIRT029875	hsa-miR-26b-5p	Microarray	19088304
MIRT005221	hsa-let-7b-5p	Proteomics;Other	18668040
MIRT050878	hsa-miR-17-5p	CLASH	23622248
MIRT044359	hsa-miR-106b-5p	CLASH	23622248
MIRT040115	hsa-miR-615-3p	CLASH	23622248
MIRT718609	hsa-miR-1324	HITS-CLIP	19536157
MIRT718608	hsa-miR-4638-3p	HITS-CLIP	19536157
MIRT718607	hsa-miR-378a-3p	HITS-CLIP	19536157
MIRT718606	hsa-miR-378b	HITS-CLIP	19536157
MIRT718605	hsa-miR-378c	HITS-CLIP	19536157
MIRT718604	hsa-miR-378d	HITS-CLIP	19536157
MIRT718603	hsa-miR-378e	HITS-CLIP	19536157
MIRT718602	hsa-miR-378f	HITS-CLIP	19536157
MIRT718601	hsa-miR-378h	HITS-CLIP	19536157
MIRT718600	hsa-miR-378i	HITS-CLIP	19536157
MIRT718599	hsa-miR-422a	HITS-CLIP	19536157
MIRT718598	hsa-miR-149-5p	HITS-CLIP	19536157
MIRT551408	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT551407	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT551406	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT544903	hsa-miR-513b-3p	PAR-CLIP	21572407
MIRT544902	hsa-miR-4729	PAR-CLIP	21572407
MIRT551405	hsa-miR-4795-5p	PAR-CLIP	21572407
MIRT551404	hsa-miR-298	PAR-CLIP	21572407
MIRT544901	hsa-miR-616-3p	PAR-CLIP	21572407
MIRT544900	hsa-miR-4775	PAR-CLIP	21572407
MIRT544899	hsa-miR-5696	PAR-CLIP	21572407
MIRT551403	hsa-miR-3616-5p	PAR-CLIP	21572407
MIRT551402	hsa-miR-573	PAR-CLIP	21572407
MIRT544898	hsa-miR-6869-5p	PAR-CLIP	21572407
MIRT544897	hsa-miR-8081	PAR-CLIP	21572407
MIRT544903	hsa-miR-513b-3p	PAR-CLIP	21572407
MIRT544902	hsa-miR-4729	PAR-CLIP	21572407
MIRT544901	hsa-miR-616-3p	PAR-CLIP	21572407
MIRT544900	hsa-miR-4775	PAR-CLIP	21572407
MIRT544899	hsa-miR-5696	PAR-CLIP	21572407
MIRT544898	hsa-miR-6869-5p	PAR-CLIP	21572407
MIRT544897	hsa-miR-8081	PAR-CLIP	21572407
MIRT718609	hsa-miR-1324	HITS-CLIP	19536157
MIRT718608	hsa-miR-4638-3p	HITS-CLIP	19536157
MIRT718607	hsa-miR-378a-3p	HITS-CLIP	19536157
MIRT718606	hsa-miR-378b	HITS-CLIP	19536157
MIRT718605	hsa-miR-378c	HITS-CLIP	19536157
MIRT718604	hsa-miR-378d	HITS-CLIP	19536157
MIRT718603	hsa-miR-378e	HITS-CLIP	19536157
MIRT718602	hsa-miR-378f	HITS-CLIP	19536157
MIRT718601	hsa-miR-378h	HITS-CLIP	19536157
MIRT718600	hsa-miR-378i	HITS-CLIP	19536157
MIRT718599	hsa-miR-422a	HITS-CLIP	19536157
MIRT718598	hsa-miR-149-5p	HITS-CLIP	19536157
MIRT551408	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT551407	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT551406	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT544903	hsa-miR-513b-3p	PAR-CLIP	21572407
MIRT544902	hsa-miR-4729	PAR-CLIP	21572407
MIRT551405	hsa-miR-4795-5p	PAR-CLIP	21572407
MIRT551404	hsa-miR-298	PAR-CLIP	21572407
MIRT544901	hsa-miR-616-3p	PAR-CLIP	21572407
MIRT544900	hsa-miR-4775	PAR-CLIP	21572407
MIRT544899	hsa-miR-5696	PAR-CLIP	21572407
MIRT551403	hsa-miR-3616-5p	PAR-CLIP	21572407
MIRT551402	hsa-miR-573	PAR-CLIP	21572407
MIRT544898	hsa-miR-6869-5p	PAR-CLIP	21572407
MIRT544897	hsa-miR-8081	PAR-CLIP	21572407
MIRT544903	hsa-miR-513b-3p	PAR-CLIP	21572407
MIRT544902	hsa-miR-4729	PAR-CLIP	21572407
MIRT544901	hsa-miR-616-3p	PAR-CLIP	21572407
MIRT544900	hsa-miR-4775	PAR-CLIP	21572407
MIRT544899	hsa-miR-5696	PAR-CLIP	21572407
MIRT544898	hsa-miR-6869-5p	PAR-CLIP	21572407
MIRT544897	hsa-miR-8081	PAR-CLIP	21572407
MIRT927633	hsa-miR-1252	CLIP-seq
MIRT927634	hsa-miR-216b	CLIP-seq
MIRT927635	hsa-miR-3192	CLIP-seq
MIRT927636	hsa-miR-3591-3p	CLIP-seq
MIRT927637	hsa-miR-3614-3p	CLIP-seq
MIRT927638	hsa-miR-3622a-3p	CLIP-seq
MIRT927639	hsa-miR-3622b-3p	CLIP-seq
MIRT927640	hsa-miR-3675-3p	CLIP-seq
MIRT927641	hsa-miR-370	CLIP-seq
MIRT927642	hsa-miR-378	CLIP-seq
MIRT927643	hsa-miR-4271	CLIP-seq
MIRT927644	hsa-miR-4329	CLIP-seq
MIRT927645	hsa-miR-4533	CLIP-seq
MIRT927646	hsa-miR-4663	CLIP-seq
MIRT927647	hsa-miR-4666-5p	CLIP-seq
MIRT927648	hsa-miR-4716-3p	CLIP-seq
MIRT927649	hsa-miR-4725-3p	CLIP-seq
MIRT927650	hsa-miR-4733-3p	CLIP-seq
MIRT927651	hsa-miR-4747-5p	CLIP-seq
MIRT927652	hsa-miR-495	CLIP-seq
MIRT927653	hsa-miR-600	CLIP-seq
MIRT927654	hsa-miR-625	CLIP-seq
MIRT927655	hsa-miR-665	CLIP-seq
MIRT1974764	hsa-miR-1256	CLIP-seq
MIRT1974765	hsa-miR-125a-5p	CLIP-seq
MIRT1974766	hsa-miR-125b	CLIP-seq
MIRT1974767	hsa-miR-149	CLIP-seq
MIRT1974768	hsa-miR-1912	CLIP-seq
MIRT1974769	hsa-miR-1972	CLIP-seq
MIRT927634	hsa-miR-216b	CLIP-seq
MIRT1974770	hsa-miR-219-1-3p	CLIP-seq
MIRT1974771	hsa-miR-2861	CLIP-seq
MIRT1974772	hsa-miR-3187-3p	CLIP-seq
MIRT927637	hsa-miR-3614-3p	CLIP-seq
MIRT1974773	hsa-miR-3620	CLIP-seq
MIRT927642	hsa-miR-378	CLIP-seq
MIRT1974774	hsa-miR-4292	CLIP-seq
MIRT1974775	hsa-miR-4308	CLIP-seq
MIRT1974776	hsa-miR-4319	CLIP-seq
MIRT1974777	hsa-miR-4529-5p	CLIP-seq
MIRT1974778	hsa-miR-4682	CLIP-seq
MIRT1974779	hsa-miR-4684-3p	CLIP-seq
MIRT1974780	hsa-miR-4731-5p	CLIP-seq
MIRT1974781	hsa-miR-4777-5p	CLIP-seq
MIRT1974782	hsa-miR-485-5p	CLIP-seq
MIRT1974783	hsa-miR-518d-5p	CLIP-seq
MIRT1974784	hsa-miR-519b-5p	CLIP-seq
MIRT1974785	hsa-miR-519c-5p	CLIP-seq
MIRT1974786	hsa-miR-520c-5p	CLIP-seq
MIRT1974787	hsa-miR-526a	CLIP-seq
MIRT1974788	hsa-miR-571	CLIP-seq
MIRT927653	hsa-miR-600	CLIP-seq
MIRT1974764	hsa-miR-1256	CLIP-seq
MIRT927636	hsa-miR-3591-3p	CLIP-seq
MIRT2210145	hsa-miR-3647-5p	CLIP-seq
MIRT927642	hsa-miR-378	CLIP-seq
MIRT2210146	hsa-miR-3913-3p	CLIP-seq
MIRT2210147	hsa-miR-3975	CLIP-seq
MIRT2210148	hsa-miR-4327	CLIP-seq
MIRT2210149	hsa-miR-4426	CLIP-seq
MIRT2210150	hsa-miR-4453	CLIP-seq
MIRT2210151	hsa-miR-4459	CLIP-seq
MIRT2210152	hsa-miR-4538	CLIP-seq
MIRT2210153	hsa-miR-4639-3p	CLIP-seq
MIRT2210154	hsa-miR-4646-5p	CLIP-seq
MIRT2210155	hsa-miR-4647	CLIP-seq
MIRT2210156	hsa-miR-4662b	CLIP-seq
MIRT2210157	hsa-miR-4695-5p	CLIP-seq
MIRT927650	hsa-miR-4733-3p	CLIP-seq
MIRT2210158	hsa-miR-489	CLIP-seq
MIRT2210159	hsa-miR-519a	CLIP-seq
MIRT927653	hsa-miR-600	CLIP-seq
MIRT927655	hsa-miR-665	CLIP-seq
MIRT1974771	hsa-miR-2861	CLIP-seq
MIRT1974772	hsa-miR-3187-3p	CLIP-seq
MIRT927635	hsa-miR-3192	CLIP-seq
MIRT927636	hsa-miR-3591-3p	CLIP-seq
MIRT2210147	hsa-miR-3975	CLIP-seq
MIRT1974774	hsa-miR-4292	CLIP-seq
MIRT1974775	hsa-miR-4308	CLIP-seq
MIRT2210151	hsa-miR-4459	CLIP-seq
MIRT1974777	hsa-miR-4529-5p	CLIP-seq
MIRT2514068	hsa-miR-4670-3p	CLIP-seq
MIRT2210157	hsa-miR-4695-5p	CLIP-seq
MIRT2514069	hsa-miR-4724-3p	CLIP-seq
MIRT1974780	hsa-miR-4731-5p	CLIP-seq
MIRT927650	hsa-miR-4733-3p	CLIP-seq
MIRT1974781	hsa-miR-4777-5p	CLIP-seq
MIRT1974782	hsa-miR-485-5p	CLIP-seq
MIRT927652	hsa-miR-495	CLIP-seq
MIRT1974783	hsa-miR-518d-5p	CLIP-seq
MIRT1974784	hsa-miR-519b-5p	CLIP-seq
MIRT1974785	hsa-miR-519c-5p	CLIP-seq
MIRT1974786	hsa-miR-520c-5p	CLIP-seq
MIRT1974787	hsa-miR-526a	CLIP-seq
MIRT2514070	hsa-miR-548aa	CLIP-seq
MIRT927655	hsa-miR-665	CLIP-seq
MIRT1974771	hsa-miR-2861	CLIP-seq
MIRT1974772	hsa-miR-3187-3p	CLIP-seq
MIRT927635	hsa-miR-3192	CLIP-seq
MIRT927636	hsa-miR-3591-3p	CLIP-seq
MIRT2210147	hsa-miR-3975	CLIP-seq
MIRT1974774	hsa-miR-4292	CLIP-seq
MIRT1974775	hsa-miR-4308	CLIP-seq
MIRT2210151	hsa-miR-4459	CLIP-seq
MIRT1974777	hsa-miR-4529-5p	CLIP-seq
MIRT2514068	hsa-miR-4670-3p	CLIP-seq
MIRT2210157	hsa-miR-4695-5p	CLIP-seq
MIRT2514069	hsa-miR-4724-3p	CLIP-seq
MIRT1974780	hsa-miR-4731-5p	CLIP-seq
MIRT927650	hsa-miR-4733-3p	CLIP-seq
MIRT1974781	hsa-miR-4777-5p	CLIP-seq
MIRT1974782	hsa-miR-485-5p	CLIP-seq
MIRT927652	hsa-miR-495	CLIP-seq
MIRT1974783	hsa-miR-518d-5p	CLIP-seq
MIRT1974784	hsa-miR-519b-5p	CLIP-seq
MIRT1974785	hsa-miR-519c-5p	CLIP-seq
MIRT1974786	hsa-miR-520c-5p	CLIP-seq
MIRT1974787	hsa-miR-526a	CLIP-seq
MIRT2514070	hsa-miR-548aa	CLIP-seq
MIRT927655	hsa-miR-665	CLIP-seq

Gene ontology (GO) Show/Hide all (34)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000287	Function	Magnesium ion binding	IEA
GO:0000287	Function	Magnesium ion binding	ISS
GO:0005515	Function	Protein binding	IPI	16189514, 25416956, 28514442, 31515488, 32296183, 33961781
GO:0005634	Component	Nucleus	IDA	24467396
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IDA	24467396
GO:0005739	Component	Mitochondrion	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	24467396
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	ISS
GO:0006253	Process	DCTP catabolic process	IBA
GO:0006253	Process	DCTP catabolic process	IMP	24467396
GO:0009143	Process	Nucleoside triphosphate catabolic process	IDA	24467396
GO:0009143	Process	Nucleoside triphosphate catabolic process	IEA
GO:0009143	Process	Nucleoside triphosphate catabolic process	ISS
GO:0016462	Function	Pyrophosphatase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0032556	Function	Pyrimidine deoxyribonucleotide binding	IEA
GO:0042262	Process	DNA protection	IBA
GO:0042262	Process	DNA protection	IMP	24467396
GO:0042802	Function	Identical protein binding	IEA
GO:0042802	Function	Identical protein binding	IPI	16169070, 16189514, 25416956, 32296183
GO:0046076	Process	DTTP catabolic process	IMP	24467396
GO:0046872	Function	Metal ion binding	IEA
GO:0047429	Function	Nucleoside triphosphate diphosphatase activity	IDA	24467396
GO:0047429	Function	Nucleoside triphosphate diphosphatase activity	IEA
GO:0047429	Function	Nucleoside triphosphate diphosphatase activity	ISS
GO:0047840	Function	DCTP diphosphatase activity	IBA
GO:0047840	Function	DCTP diphosphatase activity	IDA	24467396
GO:0047840	Function	DCTP diphosphatase activity	IEA

Other IDs

• MIM: 615840
• HGNC: 28777
• e!Ensembl: ENSG00000179958

Protein

• UniProt ID: Q9H773
• Protein name: dCTP pyrophosphatase 1 (EC 3.6.1.12) (Deoxycytidine-triphosphatase 1) (dCTPase 1) (RS21C6) (XTP3-transactivated gene A protein)
• Protein function: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect
• PDB: 7MU5
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12643	MazG-like	59 → 144	MazG-like family	Domain

• Sequence:

  MSVAGGEIRGDTGGEDTAAPGRFSFSPEPTLEDIRRLHAEFAAERDWEQFHQPRNLLLAL
  VGEVGELAELFQWKTDGEPGPQGWSPRERAALQEELSDVLIYLVALAARCRVDLPLAVLS
  KMDINRRRYPAHLARSSSRKYTELPHGAISEDQAVGPADIPCDSTGQTST

• Sequence length: 170

Pathways

KEGG Pathway

Pyrimidine metabolism

Metabolic pathways

Nucleotide metabolism

Related Genes

Sort by: Blended Diseases Pathways Evidence source

ASMTL 2 shared pathwaysPyrimidine metabolism, Nucleotide metabolism Related via 2 shared pathways including Pyrimidine metabolism, Nucleotide metabolism. NT5C3B 2 shared pathwaysPyrimidine metabolism, Nucleotide metabolism Related via 2 shared pathways including Pyrimidine metabolism, Nucleotide metabolism. CANT1 2 shared pathwaysPyrimidine metabolism, Nucleotide metabolism Related via 2 shared pathways including Pyrimidine metabolism, Nucleotide metabolism. CMPK2 2 shared pathwaysPyrimidine metabolism, Nucleotide metabolism Related via 2 shared pathways including Pyrimidine metabolism, Nucleotide metabolism. DCTD 2 shared pathwaysPyrimidine metabolism, Nucleotide metabolism Related via 2 shared pathways including Pyrimidine metabolism, Nucleotide metabolism.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
ASMTL	0	[]	2	["Pyrimidine metabolism","Nucleotide metabolism"]	0	[]
NT5C3B	0	[]	2	["Pyrimidine metabolism","Nucleotide metabolism"]	0	[]
CANT1	0	[]	2	["Pyrimidine metabolism","Nucleotide metabolism"]	0	[]
CMPK2	0	[]	2	["Pyrimidine metabolism","Nucleotide metabolism"]	0	[]
DCTD	0	[]	2	["Pyrimidine metabolism","Nucleotide metabolism"]	0	[]

Diseases Linked via Similar Genes

Myeloid leukemia Linked via 1 of 5 related genesASMTL Desbuquois dysplasia Linked via 1 of 5 related genesCANT1 Desbuquois syndrome Linked via 1 of 5 related genesCANT1 Epiphyseal dysplasia Linked via 1 of 5 related genesCANT1 Larsen syndrome Linked via 1 of 5 related genesCANT1

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Myeloid leukemia	1	["ASMTL"]
Desbuquois dysplasia	1	["CANT1"]
Desbuquois syndrome	1	["CANT1"]
Epiphyseal dysplasia	1	["CANT1"]
Larsen syndrome	1	["CANT1"]