DCAF12 (DDB1 and CUL4 associated factor 12)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 25853 |
| Gene name | DDB1 and CUL4 associated factor 12 |
| Gene symbol | DCAF12 |
| Synonyms (NCBI Gene) |
CT102KIAA1892TCC52WDR40A
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| Chromosome | 9 |
| Chromosome location | 9p13.3 |
| Summary | This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. [provided by RefSeq, Jul 20 |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q5T6F0 | |
| Protein name | DDB1- and CUL4-associated factor 12 (Centrosome-related protein TCC52) (Testis cancer centrosome-related protein) (WD repeat-containing protein 40A) | |
| Protein function | Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to t | |
| PDB | 3I7P , 8AJM , 8AJN , 8AJO , 8T9A | |
| Family and domains | ||
| Tissue specificity | TISSUE SPECIFICITY: Highly expressed in lung cancer tissues and some cancer cell lines (PubMed:18957058). Restricted expression in normal testis (PubMed:18957058). {ECO:0000269|PubMed:18957058}. | |
| Sequence |
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| Sequence length | 453 | |
| Interactions | View interactions | |
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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Related Genes
Genes most often co-reported with DCAF12 across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to DCAF12 (see Related Genes above), that are NOT already directly curated for DCAF12 itself -- a lead worth checking, not a confirmed association.
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