DCAF11 (DDB1 and CUL4 associated factor 11)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 80344
• Gene name: DDB1 and CUL4 associated factor 11
• Gene symbol: DCAF11
• Synonyms (NCBI Gene): GL014, PRO2389, WDR23
• Chromosome: 14
• Chromosome location: 14q12
• Summary: This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. Multiple alternatively spli

miRNA Show/Hide all (302)

miRTarBase ID	miRNA	Experiments	Reference
MIRT044841	hsa-miR-320a	CLASH	23622248
MIRT044841	hsa-miR-320a	CLASH	23622248
MIRT042700	hsa-miR-346	CLASH	23622248
MIRT924507	hsa-miR-1207-5p	CLIP-seq
MIRT924508	hsa-miR-140-3p	CLIP-seq
MIRT924509	hsa-miR-190	CLIP-seq
MIRT924510	hsa-miR-190b	CLIP-seq
MIRT924511	hsa-miR-1976	CLIP-seq
MIRT924512	hsa-miR-205	CLIP-seq
MIRT924513	hsa-miR-2278	CLIP-seq
MIRT924514	hsa-miR-24	CLIP-seq
MIRT924515	hsa-miR-2861	CLIP-seq
MIRT924516	hsa-miR-3126-5p	CLIP-seq
MIRT924517	hsa-miR-3157-3p	CLIP-seq
MIRT924518	hsa-miR-3177-5p	CLIP-seq
MIRT924519	hsa-miR-34a	CLIP-seq
MIRT924520	hsa-miR-34c-5p	CLIP-seq
MIRT924521	hsa-miR-3616-3p	CLIP-seq
MIRT924522	hsa-miR-3689a-5p	CLIP-seq
MIRT924523	hsa-miR-3689b	CLIP-seq
MIRT924524	hsa-miR-3689e	CLIP-seq
MIRT924525	hsa-miR-3689f	CLIP-seq
MIRT924526	hsa-miR-3918	CLIP-seq
MIRT924527	hsa-miR-4257	CLIP-seq
MIRT924528	hsa-miR-4284	CLIP-seq
MIRT924529	hsa-miR-4312	CLIP-seq
MIRT924530	hsa-miR-4419a	CLIP-seq
MIRT924531	hsa-miR-4436b-3p	CLIP-seq
MIRT924532	hsa-miR-4461	CLIP-seq
MIRT924533	hsa-miR-4468	CLIP-seq
MIRT924534	hsa-miR-449a	CLIP-seq
MIRT924535	hsa-miR-449b	CLIP-seq
MIRT924536	hsa-miR-4510	CLIP-seq
MIRT924537	hsa-miR-4512	CLIP-seq
MIRT924538	hsa-miR-4676-5p	CLIP-seq
MIRT924539	hsa-miR-4717-5p	CLIP-seq
MIRT924540	hsa-miR-4722-3p	CLIP-seq
MIRT924541	hsa-miR-4724-3p	CLIP-seq
MIRT924542	hsa-miR-4729	CLIP-seq
MIRT924543	hsa-miR-4752	CLIP-seq
MIRT924544	hsa-miR-4763-3p	CLIP-seq
MIRT924545	hsa-miR-4763-5p	CLIP-seq
MIRT924546	hsa-miR-4764-5p	CLIP-seq
MIRT924547	hsa-miR-4786-3p	CLIP-seq
MIRT924548	hsa-miR-4793-3p	CLIP-seq
MIRT924549	hsa-miR-512-5p	CLIP-seq
MIRT924550	hsa-miR-548ac	CLIP-seq
MIRT924551	hsa-miR-548ae	CLIP-seq
MIRT924552	hsa-miR-548aj	CLIP-seq
MIRT924553	hsa-miR-548am	CLIP-seq
MIRT924554	hsa-miR-548d-3p	CLIP-seq
MIRT924555	hsa-miR-548x	CLIP-seq
MIRT924556	hsa-miR-548z	CLIP-seq
MIRT924557	hsa-miR-575	CLIP-seq
MIRT924558	hsa-miR-579	CLIP-seq
MIRT924559	hsa-miR-767-3p	CLIP-seq
MIRT924560	hsa-miR-1271	CLIP-seq
MIRT924561	hsa-miR-197	CLIP-seq
MIRT924562	hsa-miR-3135b	CLIP-seq
MIRT924563	hsa-miR-3652	CLIP-seq
MIRT924564	hsa-miR-3929	CLIP-seq
MIRT924565	hsa-miR-4419b	CLIP-seq
MIRT924566	hsa-miR-4430	CLIP-seq
MIRT924567	hsa-miR-4438	CLIP-seq
MIRT924568	hsa-miR-4478	CLIP-seq
MIRT924569	hsa-miR-4705	CLIP-seq
MIRT924570	hsa-miR-4759	CLIP-seq
MIRT924571	hsa-miR-5095	CLIP-seq
MIRT924572	hsa-miR-645	CLIP-seq
MIRT924573	hsa-miR-96	CLIP-seq
MIRT1973893	hsa-miR-1182	CLIP-seq
MIRT924507	hsa-miR-1207-5p	CLIP-seq
MIRT924560	hsa-miR-1271	CLIP-seq
MIRT1973894	hsa-miR-1289	CLIP-seq
MIRT1973895	hsa-miR-129-5p	CLIP-seq
MIRT924514	hsa-miR-24	CLIP-seq
MIRT924515	hsa-miR-2861	CLIP-seq
MIRT924562	hsa-miR-3135b	CLIP-seq
MIRT1973896	hsa-miR-3149	CLIP-seq
MIRT924517	hsa-miR-3157-3p	CLIP-seq
MIRT1973897	hsa-miR-3170	CLIP-seq
MIRT1973898	hsa-miR-3179	CLIP-seq
MIRT1973899	hsa-miR-320b	CLIP-seq
MIRT1973900	hsa-miR-320c	CLIP-seq
MIRT1973901	hsa-miR-320d	CLIP-seq
MIRT1973902	hsa-miR-338-3p	CLIP-seq
MIRT924521	hsa-miR-3616-3p	CLIP-seq
MIRT1973903	hsa-miR-3649	CLIP-seq
MIRT924563	hsa-miR-3652	CLIP-seq
MIRT1973904	hsa-miR-3664-5p	CLIP-seq
MIRT1973905	hsa-miR-3672	CLIP-seq
MIRT924526	hsa-miR-3918	CLIP-seq
MIRT924564	hsa-miR-3929	CLIP-seq
MIRT1973906	hsa-miR-3936	CLIP-seq
MIRT924565	hsa-miR-4419b	CLIP-seq
MIRT1973907	hsa-miR-4423-5p	CLIP-seq
MIRT1973908	hsa-miR-4429	CLIP-seq
MIRT924566	hsa-miR-4430	CLIP-seq
MIRT924531	hsa-miR-4436b-3p	CLIP-seq
MIRT1973909	hsa-miR-4437	CLIP-seq
MIRT1973910	hsa-miR-4475	CLIP-seq
MIRT924568	hsa-miR-4478	CLIP-seq
MIRT924537	hsa-miR-4512	CLIP-seq
MIRT1973911	hsa-miR-4530	CLIP-seq
MIRT1973912	hsa-miR-4639-3p	CLIP-seq
MIRT1973913	hsa-miR-4659a-5p	CLIP-seq
MIRT1973914	hsa-miR-4659b-5p	CLIP-seq
MIRT924569	hsa-miR-4705	CLIP-seq
MIRT1973915	hsa-miR-4714-3p	CLIP-seq
MIRT1973916	hsa-miR-4716-5p	CLIP-seq
MIRT924544	hsa-miR-4763-3p	CLIP-seq
MIRT924545	hsa-miR-4763-5p	CLIP-seq
MIRT1973917	hsa-miR-4776-3p	CLIP-seq
MIRT1973918	hsa-miR-550a	CLIP-seq
MIRT924572	hsa-miR-645	CLIP-seq
MIRT1973919	hsa-miR-766	CLIP-seq
MIRT924573	hsa-miR-96	CLIP-seq
MIRT924562	hsa-miR-3135b	CLIP-seq
MIRT924563	hsa-miR-3652	CLIP-seq
MIRT924566	hsa-miR-4430	CLIP-seq
MIRT2209371	hsa-miR-106a	CLIP-seq
MIRT2209372	hsa-miR-106b	CLIP-seq
MIRT1973893	hsa-miR-1182	CLIP-seq
MIRT2209373	hsa-miR-1200	CLIP-seq
MIRT2209374	hsa-miR-1228	CLIP-seq
MIRT2209375	hsa-miR-1260	CLIP-seq
MIRT2209376	hsa-miR-1260b	CLIP-seq
MIRT2209377	hsa-miR-1273f	CLIP-seq
MIRT1973894	hsa-miR-1289	CLIP-seq
MIRT2209378	hsa-miR-1297	CLIP-seq
MIRT2209379	hsa-miR-149	CLIP-seq
MIRT2209380	hsa-miR-150	CLIP-seq
MIRT2209381	hsa-miR-17	CLIP-seq
MIRT924561	hsa-miR-197	CLIP-seq
MIRT924511	hsa-miR-1976	CLIP-seq
MIRT2209382	hsa-miR-20a	CLIP-seq
MIRT2209383	hsa-miR-20b	CLIP-seq
MIRT2209384	hsa-miR-2277-3p	CLIP-seq
MIRT924514	hsa-miR-24	CLIP-seq
MIRT2209385	hsa-miR-26a	CLIP-seq
MIRT2209386	hsa-miR-26b	CLIP-seq
MIRT924515	hsa-miR-2861	CLIP-seq
MIRT2209387	hsa-miR-302a	CLIP-seq
MIRT2209388	hsa-miR-302b	CLIP-seq
MIRT2209389	hsa-miR-302c	CLIP-seq
MIRT2209390	hsa-miR-302d	CLIP-seq
MIRT2209391	hsa-miR-302e	CLIP-seq
MIRT2209392	hsa-miR-3064-5p	CLIP-seq
MIRT2209393	hsa-miR-3117-3p	CLIP-seq
MIRT2209394	hsa-miR-3126-3p	CLIP-seq
MIRT924562	hsa-miR-3135b	CLIP-seq
MIRT2209395	hsa-miR-3159	CLIP-seq
MIRT2209396	hsa-miR-3166	CLIP-seq
MIRT2209397	hsa-miR-3169	CLIP-seq
MIRT1973897	hsa-miR-3170	CLIP-seq
MIRT2209398	hsa-miR-3176	CLIP-seq
MIRT924563	hsa-miR-3652	CLIP-seq
MIRT2209399	hsa-miR-3663-5p	CLIP-seq
MIRT1973904	hsa-miR-3664-5p	CLIP-seq
MIRT1973905	hsa-miR-3672	CLIP-seq
MIRT2209400	hsa-miR-3674	CLIP-seq
MIRT2209401	hsa-miR-371-5p	CLIP-seq
MIRT2209402	hsa-miR-371b-5p	CLIP-seq
MIRT2209403	hsa-miR-372	CLIP-seq
MIRT2209404	hsa-miR-373	CLIP-seq
MIRT2209405	hsa-miR-3922-3p	CLIP-seq
MIRT924564	hsa-miR-3929	CLIP-seq
MIRT2209406	hsa-miR-4279	CLIP-seq
MIRT924528	hsa-miR-4284	CLIP-seq
MIRT2209407	hsa-miR-4324	CLIP-seq
MIRT924565	hsa-miR-4419b	CLIP-seq
MIRT1973907	hsa-miR-4423-5p	CLIP-seq
MIRT924566	hsa-miR-4430	CLIP-seq
MIRT2209408	hsa-miR-4435	CLIP-seq
MIRT924567	hsa-miR-4438	CLIP-seq
MIRT2209409	hsa-miR-4455	CLIP-seq
MIRT2209410	hsa-miR-4465	CLIP-seq
MIRT924568	hsa-miR-4478	CLIP-seq
MIRT1973912	hsa-miR-4639-3p	CLIP-seq
MIRT1973913	hsa-miR-4659a-5p	CLIP-seq
MIRT1973914	hsa-miR-4659b-5p	CLIP-seq
MIRT924538	hsa-miR-4676-5p	CLIP-seq
MIRT2209411	hsa-miR-4693-3p	CLIP-seq
MIRT1973915	hsa-miR-4714-3p	CLIP-seq
MIRT1973916	hsa-miR-4716-5p	CLIP-seq
MIRT924540	hsa-miR-4722-3p	CLIP-seq
MIRT2209412	hsa-miR-4732-5p	CLIP-seq
MIRT2209413	hsa-miR-4735-5p	CLIP-seq
MIRT2209414	hsa-miR-4756-3p	CLIP-seq
MIRT924570	hsa-miR-4759	CLIP-seq
MIRT2209415	hsa-miR-4775	CLIP-seq
MIRT1973917	hsa-miR-4776-3p	CLIP-seq
MIRT924548	hsa-miR-4793-3p	CLIP-seq
MIRT2209416	hsa-miR-4794	CLIP-seq
MIRT924571	hsa-miR-5095	CLIP-seq
MIRT2209417	hsa-miR-513c	CLIP-seq
MIRT2209418	hsa-miR-514b-5p	CLIP-seq
MIRT2209419	hsa-miR-519d	CLIP-seq
MIRT2209420	hsa-miR-520a-3p	CLIP-seq
MIRT2209421	hsa-miR-520b	CLIP-seq
MIRT2209422	hsa-miR-520c-3p	CLIP-seq
MIRT2209423	hsa-miR-520d-3p	CLIP-seq
MIRT2209424	hsa-miR-520e	CLIP-seq
MIRT2209425	hsa-miR-520g	CLIP-seq
MIRT2209426	hsa-miR-520h	CLIP-seq
MIRT2209427	hsa-miR-544b	CLIP-seq
MIRT2209428	hsa-miR-562	CLIP-seq
MIRT924557	hsa-miR-575	CLIP-seq
MIRT2209429	hsa-miR-590-3p	CLIP-seq
MIRT2209430	hsa-miR-609	CLIP-seq
MIRT924572	hsa-miR-645	CLIP-seq
MIRT2209431	hsa-miR-922	CLIP-seq
MIRT2209432	hsa-miR-93	CLIP-seq
MIRT924528	hsa-miR-4284	CLIP-seq
MIRT2209409	hsa-miR-4455	CLIP-seq
MIRT924569	hsa-miR-4705	CLIP-seq
MIRT2209430	hsa-miR-609	CLIP-seq
MIRT924562	hsa-miR-3135b	CLIP-seq
MIRT924563	hsa-miR-3652	CLIP-seq
MIRT924566	hsa-miR-4430	CLIP-seq
MIRT2513118	hsa-miR-1197	CLIP-seq
MIRT2209374	hsa-miR-1228	CLIP-seq
MIRT2513119	hsa-miR-1245b-3p	CLIP-seq
MIRT2513120	hsa-miR-181a	CLIP-seq
MIRT2513121	hsa-miR-181b	CLIP-seq
MIRT2513122	hsa-miR-181c	CLIP-seq
MIRT2513123	hsa-miR-181d	CLIP-seq
MIRT2209384	hsa-miR-2277-3p	CLIP-seq
MIRT924514	hsa-miR-24	CLIP-seq
MIRT2513124	hsa-miR-3143	CLIP-seq
MIRT2209396	hsa-miR-3166	CLIP-seq
MIRT2513125	hsa-miR-3942-3p	CLIP-seq
MIRT2513126	hsa-miR-4262	CLIP-seq
MIRT2513127	hsa-miR-4269	CLIP-seq
MIRT2513128	hsa-miR-4436a	CLIP-seq
MIRT2513129	hsa-miR-4453	CLIP-seq
MIRT2513130	hsa-miR-4459	CLIP-seq
MIRT2513131	hsa-miR-4514	CLIP-seq
MIRT2513132	hsa-miR-4538	CLIP-seq
MIRT2513133	hsa-miR-4661-3p	CLIP-seq
MIRT2513134	hsa-miR-4692	CLIP-seq
MIRT924539	hsa-miR-4717-5p	CLIP-seq
MIRT2513135	hsa-miR-4742-5p	CLIP-seq
MIRT2513136	hsa-miR-4753-3p	CLIP-seq
MIRT2513137	hsa-miR-4757-5p	CLIP-seq
MIRT2513138	hsa-miR-4779	CLIP-seq
MIRT2513139	hsa-miR-543	CLIP-seq
MIRT924550	hsa-miR-548ac	CLIP-seq
MIRT924551	hsa-miR-548ae	CLIP-seq
MIRT924552	hsa-miR-548aj	CLIP-seq
MIRT924553	hsa-miR-548am	CLIP-seq
MIRT924554	hsa-miR-548d-3p	CLIP-seq
MIRT924555	hsa-miR-548x	CLIP-seq
MIRT924556	hsa-miR-548z	CLIP-seq
MIRT2513140	hsa-miR-576-3p	CLIP-seq
MIRT2513141	hsa-miR-663b	CLIP-seq
MIRT2513142	hsa-miR-665	CLIP-seq
MIRT2209431	hsa-miR-922	CLIP-seq
MIRT2513143	hsa-miR-942	CLIP-seq
MIRT924514	hsa-miR-24	CLIP-seq
MIRT2513118	hsa-miR-1197	CLIP-seq
MIRT2209374	hsa-miR-1228	CLIP-seq
MIRT2513119	hsa-miR-1245b-3p	CLIP-seq
MIRT2209375	hsa-miR-1260	CLIP-seq
MIRT2209376	hsa-miR-1260b	CLIP-seq
MIRT2513120	hsa-miR-181a	CLIP-seq
MIRT2513121	hsa-miR-181b	CLIP-seq
MIRT2513122	hsa-miR-181c	CLIP-seq
MIRT2513123	hsa-miR-181d	CLIP-seq
MIRT2209384	hsa-miR-2277-3p	CLIP-seq
MIRT924514	hsa-miR-24	CLIP-seq
MIRT2513124	hsa-miR-3143	CLIP-seq
MIRT2209396	hsa-miR-3166	CLIP-seq
MIRT2513125	hsa-miR-3942-3p	CLIP-seq
MIRT2513126	hsa-miR-4262	CLIP-seq
MIRT2513127	hsa-miR-4269	CLIP-seq
MIRT2513128	hsa-miR-4436a	CLIP-seq
MIRT2513129	hsa-miR-4453	CLIP-seq
MIRT2513130	hsa-miR-4459	CLIP-seq
MIRT2513131	hsa-miR-4514	CLIP-seq
MIRT2513132	hsa-miR-4538	CLIP-seq
MIRT2513133	hsa-miR-4661-3p	CLIP-seq
MIRT2679034	hsa-miR-4663	CLIP-seq
MIRT2513134	hsa-miR-4692	CLIP-seq
MIRT924539	hsa-miR-4717-5p	CLIP-seq
MIRT2513135	hsa-miR-4742-5p	CLIP-seq
MIRT2513136	hsa-miR-4753-3p	CLIP-seq
MIRT2513137	hsa-miR-4757-5p	CLIP-seq
MIRT2513138	hsa-miR-4779	CLIP-seq
MIRT2513139	hsa-miR-543	CLIP-seq
MIRT924550	hsa-miR-548ac	CLIP-seq
MIRT924551	hsa-miR-548ae	CLIP-seq
MIRT924552	hsa-miR-548aj	CLIP-seq
MIRT924553	hsa-miR-548am	CLIP-seq
MIRT924554	hsa-miR-548d-3p	CLIP-seq
MIRT924555	hsa-miR-548x	CLIP-seq
MIRT924556	hsa-miR-548z	CLIP-seq
MIRT2513140	hsa-miR-576-3p	CLIP-seq
MIRT2513141	hsa-miR-663b	CLIP-seq
MIRT2513142	hsa-miR-665	CLIP-seq
MIRT2209431	hsa-miR-922	CLIP-seq
MIRT2513143	hsa-miR-942	CLIP-seq

Gene ontology (GO) Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003016	Process	Respiratory system process	IEA
GO:0005515	Function	Protein binding	IPI	16949367, 19109893, 22190034, 27018634, 28514442, 32296183, 33961781, 35271311
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006979	Process	Response to oxidative stress	IEA
GO:0007613	Process	Memory	IEA
GO:0010467	Process	Gene expression	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0035640	Process	Exploration behavior	IEA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IBA
GO:0050821	Process	Protein stabilization	IEA
GO:0050890	Process	Cognition	IEA
GO:0080008	Component	Cul4-RING E3 ubiquitin ligase complex	IBA
GO:0080008	Component	Cul4-RING E3 ubiquitin ligase complex	IDA	16949367

Other IDs

• MIM: 613317
• HGNC: 20258
• e!Ensembl: ENSG00000100897

Protein

• UniProt ID: Q8TEB1
• Protein name: DDB1- and CUL4-associated factor 11 (WD repeat-containing protein 23)
• Protein function: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00400	WD40	473 → 511	WD domain, G-beta repeat	Repeat
  PF00400	WD40	345 → 383	WD domain, G-beta repeat	Repeat
  PF00400	WD40	295 → 336	WD domain, G-beta repeat	Repeat

• Sequence:

  MGSRNSSSAGSGSGDPSEGLPRRGAGLRRSEEEEEEDEDVDLAQVLAYLLRRGQVRLVQG
  GGAANLQFIQALLDSEEENDRAWDGRLGDRYNPPVDATPDTRELEFNEIKTQVELATGQL
  GLRRAAQKHSFPRMLHQRERGLCHRGSFSLGEQSRVISHFLPNDLGFTDSYSQKAFCGIY
  SKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSD
  YIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRT
  LQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITF
  IDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKL
  KLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLT
  NHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAEYFQDDMPESEECASAPAPVPQSST
  PFSSPQ

• Sequence length: 546

Pathways

Reactome Pathway:

Neddylation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Thyroid cancer, nonmedullary, 1	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Osteosarcoma	Osteosarcoma	BEFREE	28446751, 31598391		★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	28446751	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for DCAF11.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to DCAF11.