DBF4B (DBF4B-CDC7 kinase regulatory subunit)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 80174
• Gene name: DBF4B-CDC7 kinase regulatory subunit
• Gene symbol: DBF4B
• Synonyms (NCBI Gene): ASKL1, CHIFB, DRF1, ZDBF1B
• Chromosome: 17
• Chromosome location: 17q21.31|17q21
• Summary: This gene encodes a regulator of the cell division cycle 7 homolog (S. cerevisiae) protein, a serine-threonine kinase which links cell cycle regulation to genome duplication. This protein localizes to the nucleus and, in complex with the cell division cyc

miRNA Show/Hide all (80)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024692	hsa-miR-215-5p	Microarray	19074876
MIRT026609	hsa-miR-192-5p	Microarray	19074876
MIRT923646	hsa-miR-1244	CLIP-seq
MIRT923647	hsa-miR-1253	CLIP-seq
MIRT923648	hsa-miR-24	CLIP-seq
MIRT923649	hsa-miR-31	CLIP-seq
MIRT923650	hsa-miR-3144-5p	CLIP-seq
MIRT923651	hsa-miR-3191	CLIP-seq
MIRT923652	hsa-miR-3649	CLIP-seq
MIRT923653	hsa-miR-4652-5p	CLIP-seq
MIRT923654	hsa-miR-4667-5p	CLIP-seq
MIRT923655	hsa-miR-4682	CLIP-seq
MIRT923656	hsa-miR-4700-5p	CLIP-seq
MIRT923657	hsa-miR-548a-5p	CLIP-seq
MIRT923658	hsa-miR-548ab	CLIP-seq
MIRT923659	hsa-miR-548ak	CLIP-seq
MIRT923660	hsa-miR-548b-5p	CLIP-seq
MIRT923661	hsa-miR-548c-5p	CLIP-seq
MIRT923662	hsa-miR-548d-5p	CLIP-seq
MIRT923663	hsa-miR-548h	CLIP-seq
MIRT923664	hsa-miR-548i	CLIP-seq
MIRT923665	hsa-miR-548j	CLIP-seq
MIRT923666	hsa-miR-548k	CLIP-seq
MIRT923667	hsa-miR-548l	CLIP-seq
MIRT923668	hsa-miR-548w	CLIP-seq
MIRT923669	hsa-miR-548y	CLIP-seq
MIRT923670	hsa-miR-559	CLIP-seq
MIRT923671	hsa-miR-661	CLIP-seq
MIRT923672	hsa-miR-122	CLIP-seq
MIRT923673	hsa-miR-124	CLIP-seq
MIRT923674	hsa-miR-193a-5p	CLIP-seq
MIRT923675	hsa-miR-2276	CLIP-seq
MIRT923676	hsa-miR-3135b	CLIP-seq
MIRT923677	hsa-miR-3184	CLIP-seq
MIRT923678	hsa-miR-3190	CLIP-seq
MIRT923679	hsa-miR-365	CLIP-seq
MIRT923680	hsa-miR-3652	CLIP-seq
MIRT923681	hsa-miR-3714	CLIP-seq
MIRT923682	hsa-miR-3910	CLIP-seq
MIRT923683	hsa-miR-3919	CLIP-seq
MIRT923684	hsa-miR-3925-5p	CLIP-seq
MIRT923685	hsa-miR-3978	CLIP-seq
MIRT923686	hsa-miR-423-5p	CLIP-seq
MIRT923687	hsa-miR-4252	CLIP-seq
MIRT923688	hsa-miR-4430	CLIP-seq
MIRT923689	hsa-miR-4476	CLIP-seq
MIRT923690	hsa-miR-4491	CLIP-seq
MIRT923691	hsa-miR-4492	CLIP-seq
MIRT923692	hsa-miR-4498	CLIP-seq
MIRT923693	hsa-miR-4533	CLIP-seq
MIRT923694	hsa-miR-4657	CLIP-seq
MIRT923695	hsa-miR-4696	CLIP-seq
MIRT923696	hsa-miR-4773	CLIP-seq
MIRT923697	hsa-miR-506	CLIP-seq
MIRT923698	hsa-miR-548n	CLIP-seq
MIRT923699	hsa-miR-548t	CLIP-seq
MIRT923700	hsa-miR-555	CLIP-seq
MIRT923701	hsa-miR-762	CLIP-seq
MIRT2513009	hsa-miR-1207-5p	CLIP-seq
MIRT2513010	hsa-miR-1909	CLIP-seq
MIRT2513011	hsa-miR-3202	CLIP-seq
MIRT2513012	hsa-miR-3915	CLIP-seq
MIRT2513013	hsa-miR-3928	CLIP-seq
MIRT2513014	hsa-miR-4436b-3p	CLIP-seq
MIRT923689	hsa-miR-4476	CLIP-seq
MIRT2513015	hsa-miR-4716-3p	CLIP-seq
MIRT2513016	hsa-miR-4763-3p	CLIP-seq
MIRT2513017	hsa-miR-4768-3p	CLIP-seq
MIRT2513018	hsa-miR-589	CLIP-seq
MIRT2513009	hsa-miR-1207-5p	CLIP-seq
MIRT2513010	hsa-miR-1909	CLIP-seq
MIRT2513011	hsa-miR-3202	CLIP-seq
MIRT2513012	hsa-miR-3915	CLIP-seq
MIRT2513013	hsa-miR-3928	CLIP-seq
MIRT2513014	hsa-miR-4436b-3p	CLIP-seq
MIRT923689	hsa-miR-4476	CLIP-seq
MIRT2513015	hsa-miR-4716-3p	CLIP-seq
MIRT2513016	hsa-miR-4763-3p	CLIP-seq
MIRT2513017	hsa-miR-4768-3p	CLIP-seq
MIRT2513018	hsa-miR-589	CLIP-seq

Gene ontology (GO) Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	IDA	15668232
GO:0003676	Function	Nucleic acid binding	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183, 32814053
GO:0005634	Component	Nucleus	IDA	12065429
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA	15668232
GO:0005737	Component	Cytoplasm	IDA	15668232
GO:0008270	Function	Zinc ion binding	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	15668232
GO:0010571	Process	Positive regulation of nuclear cell cycle DNA replication	IBA
GO:0010571	Process	Positive regulation of nuclear cell cycle DNA replication	IMP	15668232
GO:0010971	Process	Positive regulation of G2/M transition of mitotic cell cycle	IMP	15668232
GO:0019901	Function	Protein kinase binding	IPI	12065429, 15668232
GO:0030295	Function	Protein kinase activator activity	IDA	12065429, 15668232
GO:0031431	Component	Dbf4-dependent protein kinase complex	IBA
GO:0043539	Function	Protein serine/threonine kinase activator activity	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:1901987	Process	Regulation of cell cycle phase transition	IBA

Other IDs

• MIM: 611661
• HGNC: 17883
• e!Ensembl: ENSG00000161692

Protein

• UniProt ID: Q8NFT6
• Protein name: Protein DBF4 homolog B (Activator of S phase kinase-like protein 1) (ASK-like protein 1) (Chiffon homolog B) (Dbf4-related factor 1)
• Protein function: Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07535	zf-DBF	296 → 340	DBF zinc finger	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. Highly expressed in testis. {ECO:0000269|PubMed:12065429}.
• Sequence:

  MSEPGKGDDCLELESSMAESRLRAPDLGVSRCLGKCQKNSPGARKHPFSGKSFYLDLPAG
  KNLQFLTGAIQQLGGVIEGFLSKEVSYIVSSRREVKAESSGKSHRGCPSPSPSEVRVETS
  AMVDPKGSHPRPSRKPVDSVPLSRGKELLQKAIRNQGSISGGGSGGSSSLLTNARSWGVR
  ILHVDEMMMHVQQLSLASLCVKKQQPKKPEGTCPAAESRTRKVARLKAPFLKIEDESRKF
  RPFHHQFKSFPEISFLGPKDASPFEAPTTLGSMHHTRESKDGEPSPRSAAHTMPRRKKGY
  CECCQEAFEELHVHLQSAQHRSFALEAHLYAEVDRIIAQLSHSFADIPFQAGLPRWSGSP
  ASDCDPLCPETLHPHQPSHPRAASPRIRKEDSCQASVTQGRAAGQQRWTESLDGVMGPPA
  SHTCVSATTLLPALPKGSREQGCLCPCPASFTQSHLVTSLALLPGEWSPAEDMPLHPSQE
  NSFAPADIPVKGPLLFPEARPWLMSARCWVRPFPFVTWGCLIPHDTTPLHEEVSPCPCLR
  LGYLYLLLTQSLWCRVRVPSLSTAGPIPRTSHPCTLAFPSYLNDHDLGHLCQAKPQGWNT
  PQPFLHCGFLAVDSG

• Sequence length: 615

Pathways

KEGG Pathway:

Cell cycle

Related Genes

No strongly related genes found yet for DBF4B.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to DBF4B.