Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	1519
Gene name	Cathepsin O
Gene symbol	CTSO
Synonyms (NCBI Gene)	CTSO1
Chromosome	4
Chromosome location	4q32.1
Summary	The protein encoded by the gene is a cysteine proteinase and a member of the papain superfamily. This proteolytic enzyme is involved in cellular protein degradation and turnover. The recombinant form of this enzyme was shown to degrade synthetic peptides

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miRTarBase ID	miRNA	Experiments
MIRT916004	hsa-miR-1286	CLIP-seq
MIRT916005	hsa-miR-361-5p	CLIP-seq
MIRT916006	hsa-miR-4305	CLIP-seq
MIRT916007	hsa-miR-4419a	CLIP-seq
MIRT916008	hsa-miR-4436a	CLIP-seq
MIRT916009	hsa-miR-4510	CLIP-seq
MIRT916010	hsa-miR-4517	CLIP-seq
MIRT916011	hsa-miR-4775	CLIP-seq
MIRT916012	hsa-miR-578	CLIP-seq
MIRT916013	hsa-miR-583	CLIP-seq
MIRT916014	hsa-miR-590-3p	CLIP-seq
MIRT1971636	hsa-miR-2355-5p	CLIP-seq
MIRT916005	hsa-miR-361-5p	CLIP-seq
MIRT1971637	hsa-miR-3674	CLIP-seq
MIRT1971638	hsa-miR-376c	CLIP-seq
MIRT1971639	hsa-miR-4773	CLIP-seq
MIRT1971640	hsa-miR-579	CLIP-seq
MIRT1971641	hsa-miR-922	CLIP-seq
MIRT2207364	hsa-miR-205	CLIP-seq
MIRT2207365	hsa-miR-570	CLIP-seq
MIRT1971640	hsa-miR-579	CLIP-seq
MIRT2510520	hsa-miR-1208	CLIP-seq
MIRT2510521	hsa-miR-1245	CLIP-seq
MIRT2510522	hsa-miR-1273f	CLIP-seq
MIRT2510523	hsa-miR-1321	CLIP-seq
MIRT2510524	hsa-miR-147	CLIP-seq
MIRT2510525	hsa-miR-1912	CLIP-seq
MIRT2510526	hsa-miR-1915	CLIP-seq
MIRT2510527	hsa-miR-19a	CLIP-seq
MIRT2510528	hsa-miR-19b	CLIP-seq
MIRT2510529	hsa-miR-25	CLIP-seq
MIRT2510530	hsa-miR-2964a-3p	CLIP-seq
MIRT2510531	hsa-miR-3130-5p	CLIP-seq
MIRT2510532	hsa-miR-3138	CLIP-seq
MIRT2510533	hsa-miR-3199	CLIP-seq
MIRT2510534	hsa-miR-32	CLIP-seq
MIRT2510535	hsa-miR-34b	CLIP-seq
MIRT2510536	hsa-miR-3606	CLIP-seq
MIRT2510537	hsa-miR-3614-5p	CLIP-seq
MIRT2510538	hsa-miR-3622a-3p	CLIP-seq
MIRT2510539	hsa-miR-3622b-3p	CLIP-seq
MIRT2510540	hsa-miR-363	CLIP-seq
MIRT2510541	hsa-miR-367	CLIP-seq
MIRT2510542	hsa-miR-3907	CLIP-seq
MIRT2510543	hsa-miR-3911	CLIP-seq
MIRT2510544	hsa-miR-4475	CLIP-seq
MIRT2510545	hsa-miR-4482	CLIP-seq
MIRT2510546	hsa-miR-4661-3p	CLIP-seq
MIRT2510547	hsa-miR-4739	CLIP-seq
MIRT2510548	hsa-miR-4756-5p	CLIP-seq
MIRT2510549	hsa-miR-4800-5p	CLIP-seq
MIRT2510550	hsa-miR-644	CLIP-seq
MIRT2510551	hsa-miR-892a	CLIP-seq
MIRT2510552	hsa-miR-921	CLIP-seq
MIRT2510553	hsa-miR-92a	CLIP-seq
MIRT2510554	hsa-miR-92b	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004197	Function	Cysteine-type endopeptidase activity	IBA
GO:0004197	Function	Cysteine-type endopeptidase activity	TAS	7929457
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005615	Component	Extracellular space	IBA
GO:0005764	Component	Lysosome	IBA
GO:0005764	Component	Lysosome	IEA
GO:0006508	Process	Proteolysis	IEA
GO:0006508	Process	Proteolysis	TAS	7929457
GO:0008233	Function	Peptidase activity	IEA
GO:0008234	Function	Cysteine-type peptidase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0051603	Process	Proteolysis involved in protein catabolic process	IBA

MIM	HGNC	e!Ensembl
600550	2542	ENSG00000256043

P43234

Protein name

Cathepsin O (EC 3.4.22.42)

Protein function

Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00112	Peptidase_C1	108 → 320	Papain family cysteine protease	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in all tissues examined. High levels seen in the ovary, kidney and placenta while low levels seen in thymus and skeletal muscle.

Sequence

MDVRALPWLPWLLWLLCRGGGDADSRAPFTPTWPRSREREAAAFRESLNRHRYLNSLFPS
ENSTAFYGINQFSYLFPEEFKAIYLRSKPSKFPRYSAEVHMSIPNVSLPLRFDWRDKQVV
TQVRNQQMCGGCWAFSVVGAVESAYAIKGKPLEDLSVQQVIDCSYNNYGCNGGSTLNALN
WLNKMQVKLVKDSEYPFKAQNGLCHYFSGSHSGFSIKGYSAYDFSDQEDEMAKALLTFGP
LVVIVDAVSWQDYLGGIIQHHCSSGEANHAVLITGFDKTGSTPYWIVRNSWGSSWGVDGY
AHVKMGSNVCGIADSVSSIFV

Sequence length

321

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Lysosome	MHC class II antigen presentation
Apoptosis

CTSO (cathepsin O)

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