CRISP1 (cysteine rich secretory protein 1)

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Gene miRNA Transcription factors Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 167
• Gene name: Cysteine rich secretory protein 1
• Gene symbol: CRISP1
• Synonyms (NCBI Gene): AEGL1, ARP, CRISP-1, HEL-S-57, HSCRISP1D, HSCRISP1G, HUMARP
• Chromosome: 6
• Chromosome location: 6p12.3
• Summary: Fertilization consists of a sequence of specific cell-cell interactions culminating in the fusion of the sperm and egg plasma membranes. Recognition, binding, and fusion occur through the interaction of complementary molecules that are localized to specif

miRNA Show/Hide all (176)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019493	hsa-miR-148b-3p	Microarray	17612493
MIRT611142	hsa-miR-6830-3p	HITS-CLIP	19536157
MIRT611141	hsa-miR-6715b-3p	HITS-CLIP	19536157
MIRT611140	hsa-miR-511-5p	HITS-CLIP	19536157
MIRT611139	hsa-miR-607	HITS-CLIP	19536157
MIRT611138	hsa-miR-1305	HITS-CLIP	19536157
MIRT611137	hsa-miR-335-3p	HITS-CLIP	19536157
MIRT616651	hsa-miR-219b-5p	HITS-CLIP	23824327
MIRT611142	hsa-miR-6830-3p	HITS-CLIP	23824327
MIRT611141	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT611140	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT611139	hsa-miR-607	HITS-CLIP	23824327
MIRT611138	hsa-miR-1305	HITS-CLIP	23824327
MIRT611137	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT611142	hsa-miR-6830-3p	HITS-CLIP	23824327
MIRT611141	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT611140	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT611137	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT616651	hsa-miR-219b-5p	HITS-CLIP	23824327
MIRT611142	hsa-miR-6830-3p	HITS-CLIP	23824327
MIRT611141	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT611140	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT611137	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT647116	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT647115	hsa-miR-323a-5p	HITS-CLIP	23824327
MIRT647114	hsa-miR-876-3p	HITS-CLIP	23824327
MIRT647113	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT647112	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT647111	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT647110	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT611142	hsa-miR-6830-3p	HITS-CLIP	23824327
MIRT611141	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT611140	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT611139	hsa-miR-607	HITS-CLIP	23824327
MIRT611138	hsa-miR-1305	HITS-CLIP	23824327
MIRT611137	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT616651	hsa-miR-219b-5p	HITS-CLIP	23824327
MIRT611142	hsa-miR-6830-3p	HITS-CLIP	23824327
MIRT611141	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT611140	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT611137	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT616651	hsa-miR-219b-5p	HITS-CLIP	23824327
MIRT611142	hsa-miR-6830-3p	HITS-CLIP	23824327
MIRT611141	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT611140	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT611139	hsa-miR-607	HITS-CLIP	23824327
MIRT611138	hsa-miR-1305	HITS-CLIP	23824327
MIRT611137	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT611141	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT611140	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT611139	hsa-miR-607	HITS-CLIP	23824327
MIRT611138	hsa-miR-1305	HITS-CLIP	23824327
MIRT611137	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT616651	hsa-miR-219b-5p	HITS-CLIP	23824327
MIRT611142	hsa-miR-6830-3p	HITS-CLIP	23824327
MIRT611141	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT611140	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT611137	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT616651	hsa-miR-219b-5p	HITS-CLIP	23824327
MIRT611142	hsa-miR-6830-3p	HITS-CLIP	23824327
MIRT611141	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT611140	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT611138	hsa-miR-1305	HITS-CLIP	23824327
MIRT611137	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT616651	hsa-miR-219b-5p	HITS-CLIP	23824327
MIRT611142	hsa-miR-6830-3p	HITS-CLIP	23824327
MIRT611141	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT611140	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT611139	hsa-miR-607	HITS-CLIP	23824327
MIRT611138	hsa-miR-1305	HITS-CLIP	23824327
MIRT611137	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT611141	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT611140	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT611139	hsa-miR-607	HITS-CLIP	23824327
MIRT611138	hsa-miR-1305	HITS-CLIP	23824327
MIRT611137	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT611141	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT611138	hsa-miR-1305	HITS-CLIP	23824327
MIRT611137	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT611142	hsa-miR-6830-3p	HITS-CLIP	23824327
MIRT611141	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT611140	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT611139	hsa-miR-607	HITS-CLIP	23824327
MIRT611138	hsa-miR-1305	HITS-CLIP	23824327
MIRT611137	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT611142	hsa-miR-6830-3p	HITS-CLIP	19536157
MIRT611141	hsa-miR-6715b-3p	HITS-CLIP	19536157
MIRT611140	hsa-miR-511-5p	HITS-CLIP	19536157
MIRT611139	hsa-miR-607	HITS-CLIP	19536157
MIRT611138	hsa-miR-1305	HITS-CLIP	19536157
MIRT611137	hsa-miR-335-3p	HITS-CLIP	19536157
MIRT616651	hsa-miR-219b-5p	HITS-CLIP	23824327
MIRT611142	hsa-miR-6830-3p	HITS-CLIP	23824327
MIRT611141	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT611140	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT611139	hsa-miR-607	HITS-CLIP	23824327
MIRT611138	hsa-miR-1305	HITS-CLIP	23824327
MIRT611137	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT611142	hsa-miR-6830-3p	HITS-CLIP	23824327
MIRT611141	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT611140	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT611137	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT616651	hsa-miR-219b-5p	HITS-CLIP	23824327
MIRT611142	hsa-miR-6830-3p	HITS-CLIP	23824327
MIRT611141	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT611140	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT611137	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT647116	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT647115	hsa-miR-323a-5p	HITS-CLIP	23824327
MIRT647114	hsa-miR-876-3p	HITS-CLIP	23824327
MIRT647113	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT647112	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT647111	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT647110	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT611142	hsa-miR-6830-3p	HITS-CLIP	23824327
MIRT611141	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT611140	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT611139	hsa-miR-607	HITS-CLIP	23824327
MIRT611138	hsa-miR-1305	HITS-CLIP	23824327
MIRT611137	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT616651	hsa-miR-219b-5p	HITS-CLIP	23824327
MIRT611142	hsa-miR-6830-3p	HITS-CLIP	23824327
MIRT611141	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT611140	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT611137	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT616651	hsa-miR-219b-5p	HITS-CLIP	23824327
MIRT611142	hsa-miR-6830-3p	HITS-CLIP	23824327
MIRT611141	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT611140	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT611139	hsa-miR-607	HITS-CLIP	23824327
MIRT611138	hsa-miR-1305	HITS-CLIP	23824327
MIRT611137	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT611141	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT611140	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT611139	hsa-miR-607	HITS-CLIP	23824327
MIRT611138	hsa-miR-1305	HITS-CLIP	23824327
MIRT611137	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT616651	hsa-miR-219b-5p	HITS-CLIP	23824327
MIRT611142	hsa-miR-6830-3p	HITS-CLIP	23824327
MIRT611141	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT611140	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT611137	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT616651	hsa-miR-219b-5p	HITS-CLIP	23824327
MIRT611142	hsa-miR-6830-3p	HITS-CLIP	23824327
MIRT611141	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT611140	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT611138	hsa-miR-1305	HITS-CLIP	23824327
MIRT611137	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT616651	hsa-miR-219b-5p	HITS-CLIP	23824327
MIRT611142	hsa-miR-6830-3p	HITS-CLIP	23824327
MIRT611141	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT611140	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT611139	hsa-miR-607	HITS-CLIP	23824327
MIRT611138	hsa-miR-1305	HITS-CLIP	23824327
MIRT611137	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT611141	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT611140	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT611139	hsa-miR-607	HITS-CLIP	23824327
MIRT611138	hsa-miR-1305	HITS-CLIP	23824327
MIRT611137	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT611141	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT611138	hsa-miR-1305	HITS-CLIP	23824327
MIRT611137	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT611142	hsa-miR-6830-3p	HITS-CLIP	23824327
MIRT611141	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT611140	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT611139	hsa-miR-607	HITS-CLIP	23824327
MIRT611138	hsa-miR-1305	HITS-CLIP	23824327
MIRT611137	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT1969659	hsa-miR-3691-5p	CLIP-seq
MIRT1969660	hsa-miR-4276	CLIP-seq
MIRT1969661	hsa-miR-4752	CLIP-seq
MIRT2386469	hsa-miR-298	CLIP-seq
MIRT1969660	hsa-miR-4276	CLIP-seq
MIRT2386470	hsa-miR-4524	CLIP-seq
MIRT2386471	hsa-miR-4668-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
AR	Unknown	11223178

Gene ontology (GO) Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005246	Function	Calcium channel regulator activity	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	TAS	8543280
GO:0005634	Component	Nucleus	HDA	21630459
GO:0007339	Process	Binding of sperm to zona pellucida	IBA
GO:0007339	Process	Binding of sperm to zona pellucida	IEA
GO:0007342	Process	Fusion of sperm to egg plasma membrane involved in single fertilization	TAS	8838800
GO:0019953	Process	Sexual reproduction	IBA
GO:0060046	Process	Regulation of acrosome reaction	IEA

Other IDs

• MIM: 601193
• HGNC: 304
• e!Ensembl: ENSG00000124812

Protein

• UniProt ID: P54107
• Protein name: Cysteine-rich secretory protein 1 (CRISP-1) (AEG-like protein) (ARP) (Acidic epididymal glycoprotein homolog)
• Protein function: May have a role in sperm-egg fusion and maturation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00188	CAP	45 → 175	Cysteine-rich secretory protein family	Domain
  PF08562	Crisp	195 → 249	Crisp	Domain

• Tissue specificity: TISSUE SPECIFICITY: Caput, corpus, and cauda regions of the epididymis, the ductus deferens, sperm and seminal plasma.
• Sequence:

  MEIKHLLFLVAAACLLPMLSMKKKSARDQFNKLVTDLPNVQEEIVNIHNALRRRVVPPAS
  NMLKMSWSEEAAQNARIFSKYCDMTESNPLERRLPNTFCGENMHMTSYPVSWSSVIGVWY
  SESTSFKHGEWTTTDDDITTDHYTQIVWATSYLIGCAIASCRQQGSPRYLYVCHYCHEGN
  DPETKNEPYKTGVPCEACPSNCEDKLCTNPCIYYDEYFDCDIQVHYLGCNHSTTILFCKA
  TCLCDTEIK

• Sequence length: 249

Related Genes

No strongly related genes found yet for CRISP1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to CRISP1.