Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	10898
Gene name	Cleavage and polyadenylation specific factor 4
Gene symbol	CPSF4
Synonyms (NCBI Gene)	CPSF30NARNEB-1NEB1
Chromosome	7
Chromosome location	7q22.1
Summary	Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific

300 Show/Hide all (300)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023215	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT028627	hsa-miR-30a-5p	Proteomics	18668040
MIRT039647	hsa-miR-615-3p	CLASH	23622248
MIRT907246	hsa-miR-1233	CLIP-seq
MIRT907247	hsa-miR-1253	CLIP-seq
MIRT907248	hsa-miR-1286	CLIP-seq
MIRT907249	hsa-miR-141	CLIP-seq
MIRT907250	hsa-miR-145	CLIP-seq
MIRT907251	hsa-miR-146b-3p	CLIP-seq
MIRT907252	hsa-miR-200a	CLIP-seq
MIRT907253	hsa-miR-214	CLIP-seq
MIRT907254	hsa-miR-23a	CLIP-seq
MIRT907255	hsa-miR-23b	CLIP-seq
MIRT907256	hsa-miR-23c	CLIP-seq
MIRT907257	hsa-miR-24	CLIP-seq
MIRT907258	hsa-miR-3155	CLIP-seq
MIRT907259	hsa-miR-3155b	CLIP-seq
MIRT907260	hsa-miR-3159	CLIP-seq
MIRT907261	hsa-miR-3180-5p	CLIP-seq
MIRT907262	hsa-miR-3184	CLIP-seq
MIRT907263	hsa-miR-331-3p	CLIP-seq
MIRT907264	hsa-miR-3619-5p	CLIP-seq
MIRT907265	hsa-miR-3622a-5p	CLIP-seq
MIRT907266	hsa-miR-3664-3p	CLIP-seq
MIRT907267	hsa-miR-3919	CLIP-seq
MIRT907268	hsa-miR-3925-3p	CLIP-seq
MIRT907269	hsa-miR-423-5p	CLIP-seq
MIRT907270	hsa-miR-4269	CLIP-seq
MIRT907271	hsa-miR-4291	CLIP-seq
MIRT907272	hsa-miR-4423-3p	CLIP-seq
MIRT907273	hsa-miR-4436a	CLIP-seq
MIRT907274	hsa-miR-4436b-3p	CLIP-seq
MIRT907275	hsa-miR-4511	CLIP-seq
MIRT907276	hsa-miR-4514	CLIP-seq
MIRT907277	hsa-miR-4530	CLIP-seq
MIRT907278	hsa-miR-4645-5p	CLIP-seq
MIRT907279	hsa-miR-4667-3p	CLIP-seq
MIRT907280	hsa-miR-4673	CLIP-seq
MIRT907281	hsa-miR-4692	CLIP-seq
MIRT907282	hsa-miR-4694-5p	CLIP-seq
MIRT907283	hsa-miR-4722-5p	CLIP-seq
MIRT907284	hsa-miR-4742-5p	CLIP-seq
MIRT907285	hsa-miR-4768-3p	CLIP-seq
MIRT907286	hsa-miR-484	CLIP-seq
MIRT907287	hsa-miR-486-5p	CLIP-seq
MIRT907288	hsa-miR-508-5p	CLIP-seq
MIRT907289	hsa-miR-582-3p	CLIP-seq
MIRT907290	hsa-miR-634	CLIP-seq
MIRT907291	hsa-miR-651	CLIP-seq
MIRT907292	hsa-miR-657	CLIP-seq
MIRT907293	hsa-miR-761	CLIP-seq
MIRT907294	hsa-miR-922	CLIP-seq
MIRT907295	hsa-miR-95	CLIP-seq
MIRT1968876	hsa-let-7a	CLIP-seq
MIRT1968877	hsa-let-7b	CLIP-seq
MIRT1968878	hsa-let-7c	CLIP-seq
MIRT1968879	hsa-let-7d	CLIP-seq
MIRT1968880	hsa-let-7e	CLIP-seq
MIRT1968881	hsa-let-7f	CLIP-seq
MIRT1968882	hsa-let-7g	CLIP-seq
MIRT1968883	hsa-let-7i	CLIP-seq
MIRT1968884	hsa-miR-1197	CLIP-seq
MIRT1968885	hsa-miR-1204	CLIP-seq
MIRT1968886	hsa-miR-1205	CLIP-seq
MIRT1968887	hsa-miR-1245b-3p	CLIP-seq
MIRT907248	hsa-miR-1286	CLIP-seq
MIRT907249	hsa-miR-141	CLIP-seq
MIRT907250	hsa-miR-145	CLIP-seq
MIRT1968888	hsa-miR-1827	CLIP-seq
MIRT1968889	hsa-miR-1909	CLIP-seq
MIRT907252	hsa-miR-200a	CLIP-seq
MIRT1968890	hsa-miR-204	CLIP-seq
MIRT1968891	hsa-miR-211	CLIP-seq
MIRT1968892	hsa-miR-2116	CLIP-seq
MIRT907253	hsa-miR-214	CLIP-seq
MIRT1968893	hsa-miR-2276	CLIP-seq
MIRT1968894	hsa-miR-2964a-5p	CLIP-seq
MIRT1968895	hsa-miR-3179	CLIP-seq
MIRT1968896	hsa-miR-3194-5p	CLIP-seq
MIRT907264	hsa-miR-3619-5p	CLIP-seq
MIRT907265	hsa-miR-3622a-5p	CLIP-seq
MIRT1968897	hsa-miR-3649	CLIP-seq
MIRT1968898	hsa-miR-3671	CLIP-seq
MIRT1968899	hsa-miR-3918	CLIP-seq
MIRT907268	hsa-miR-3925-3p	CLIP-seq
MIRT1968900	hsa-miR-3936	CLIP-seq
MIRT907270	hsa-miR-4269	CLIP-seq
MIRT1968901	hsa-miR-4273	CLIP-seq
MIRT1968902	hsa-miR-4280	CLIP-seq
MIRT1968903	hsa-miR-4293	CLIP-seq
MIRT1968904	hsa-miR-4418	CLIP-seq
MIRT907272	hsa-miR-4423-3p	CLIP-seq
MIRT907273	hsa-miR-4436a	CLIP-seq
MIRT1968905	hsa-miR-4458	CLIP-seq
MIRT1968906	hsa-miR-4459	CLIP-seq
MIRT1968907	hsa-miR-4469	CLIP-seq
MIRT1968908	hsa-miR-4500	CLIP-seq
MIRT907276	hsa-miR-4514	CLIP-seq
MIRT907277	hsa-miR-4530	CLIP-seq
MIRT1968909	hsa-miR-4640-5p	CLIP-seq
MIRT1968910	hsa-miR-4643	CLIP-seq
MIRT1968911	hsa-miR-4645-3p	CLIP-seq
MIRT1968912	hsa-miR-4649-3p	CLIP-seq
MIRT1968913	hsa-miR-4677-5p	CLIP-seq
MIRT1968914	hsa-miR-4685-5p	CLIP-seq
MIRT907281	hsa-miR-4692	CLIP-seq
MIRT1968915	hsa-miR-4700-3p	CLIP-seq
MIRT907283	hsa-miR-4722-5p	CLIP-seq
MIRT1968916	hsa-miR-4726-5p	CLIP-seq
MIRT907284	hsa-miR-4742-5p	CLIP-seq
MIRT1968917	hsa-miR-4755-3p	CLIP-seq
MIRT1968918	hsa-miR-4762-5p	CLIP-seq
MIRT1968919	hsa-miR-4772-3p	CLIP-seq
MIRT907288	hsa-miR-508-5p	CLIP-seq
MIRT1968920	hsa-miR-509-3-5p	CLIP-seq
MIRT1968921	hsa-miR-509-5p	CLIP-seq
MIRT1968922	hsa-miR-544b	CLIP-seq
MIRT1968923	hsa-miR-548n	CLIP-seq
MIRT1968924	hsa-miR-548t	CLIP-seq
MIRT1968925	hsa-miR-607	CLIP-seq
MIRT1968926	hsa-miR-642b	CLIP-seq
MIRT907292	hsa-miR-657	CLIP-seq
MIRT1968927	hsa-miR-711	CLIP-seq
MIRT907293	hsa-miR-761	CLIP-seq
MIRT1968928	hsa-miR-891b	CLIP-seq
MIRT907295	hsa-miR-95	CLIP-seq
MIRT1968929	hsa-miR-98	CLIP-seq
MIRT907248	hsa-miR-1286	CLIP-seq
MIRT907249	hsa-miR-141	CLIP-seq
MIRT907250	hsa-miR-145	CLIP-seq
MIRT1968888	hsa-miR-1827	CLIP-seq
MIRT907252	hsa-miR-200a	CLIP-seq
MIRT1968892	hsa-miR-2116	CLIP-seq
MIRT907253	hsa-miR-214	CLIP-seq
MIRT1968893	hsa-miR-2276	CLIP-seq
MIRT907254	hsa-miR-23a	CLIP-seq
MIRT907255	hsa-miR-23b	CLIP-seq
MIRT907256	hsa-miR-23c	CLIP-seq
MIRT907257	hsa-miR-24	CLIP-seq
MIRT907258	hsa-miR-3155	CLIP-seq
MIRT907259	hsa-miR-3155b	CLIP-seq
MIRT907260	hsa-miR-3159	CLIP-seq
MIRT907261	hsa-miR-3180-5p	CLIP-seq
MIRT1968896	hsa-miR-3194-5p	CLIP-seq
MIRT907264	hsa-miR-3619-5p	CLIP-seq
MIRT907265	hsa-miR-3622a-5p	CLIP-seq
MIRT2204949	hsa-miR-3647-3p	CLIP-seq
MIRT1968897	hsa-miR-3649	CLIP-seq
MIRT907266	hsa-miR-3664-3p	CLIP-seq
MIRT1968898	hsa-miR-3671	CLIP-seq
MIRT1968899	hsa-miR-3918	CLIP-seq
MIRT907268	hsa-miR-3925-3p	CLIP-seq
MIRT2204950	hsa-miR-4267	CLIP-seq
MIRT907270	hsa-miR-4269	CLIP-seq
MIRT1968901	hsa-miR-4273	CLIP-seq
MIRT2204951	hsa-miR-4279	CLIP-seq
MIRT907271	hsa-miR-4291	CLIP-seq
MIRT1968903	hsa-miR-4293	CLIP-seq
MIRT907272	hsa-miR-4423-3p	CLIP-seq
MIRT907273	hsa-miR-4436a	CLIP-seq
MIRT907274	hsa-miR-4436b-3p	CLIP-seq
MIRT1968907	hsa-miR-4469	CLIP-seq
MIRT907276	hsa-miR-4514	CLIP-seq
MIRT907277	hsa-miR-4530	CLIP-seq
MIRT1968909	hsa-miR-4640-5p	CLIP-seq
MIRT907278	hsa-miR-4645-5p	CLIP-seq
MIRT1968912	hsa-miR-4649-3p	CLIP-seq
MIRT907280	hsa-miR-4673	CLIP-seq
MIRT1968913	hsa-miR-4677-5p	CLIP-seq
MIRT1968914	hsa-miR-4685-5p	CLIP-seq
MIRT2204952	hsa-miR-4691-5p	CLIP-seq
MIRT907281	hsa-miR-4692	CLIP-seq
MIRT2204953	hsa-miR-4715-3p	CLIP-seq
MIRT907283	hsa-miR-4722-5p	CLIP-seq
MIRT1968916	hsa-miR-4726-5p	CLIP-seq
MIRT907284	hsa-miR-4742-5p	CLIP-seq
MIRT1968917	hsa-miR-4755-3p	CLIP-seq
MIRT1968918	hsa-miR-4762-5p	CLIP-seq
MIRT2204954	hsa-miR-4765	CLIP-seq
MIRT907285	hsa-miR-4768-3p	CLIP-seq
MIRT1968919	hsa-miR-4772-3p	CLIP-seq
MIRT907286	hsa-miR-484	CLIP-seq
MIRT907288	hsa-miR-508-5p	CLIP-seq
MIRT1968922	hsa-miR-544b	CLIP-seq
MIRT2204955	hsa-miR-548c-3p	CLIP-seq
MIRT1968923	hsa-miR-548n	CLIP-seq
MIRT1968924	hsa-miR-548t	CLIP-seq
MIRT1968925	hsa-miR-607	CLIP-seq
MIRT907292	hsa-miR-657	CLIP-seq
MIRT2204956	hsa-miR-759	CLIP-seq
MIRT907293	hsa-miR-761	CLIP-seq
MIRT1968928	hsa-miR-891b	CLIP-seq
MIRT907294	hsa-miR-922	CLIP-seq
MIRT907295	hsa-miR-95	CLIP-seq
MIRT907258	hsa-miR-3155	CLIP-seq
MIRT907259	hsa-miR-3155b	CLIP-seq
MIRT907273	hsa-miR-4436a	CLIP-seq
MIRT907274	hsa-miR-4436b-3p	CLIP-seq
MIRT907286	hsa-miR-484	CLIP-seq
MIRT1968876	hsa-let-7a	CLIP-seq
MIRT1968877	hsa-let-7b	CLIP-seq
MIRT1968878	hsa-let-7c	CLIP-seq
MIRT1968879	hsa-let-7d	CLIP-seq
MIRT1968880	hsa-let-7e	CLIP-seq
MIRT1968881	hsa-let-7f	CLIP-seq
MIRT1968882	hsa-let-7g	CLIP-seq
MIRT1968883	hsa-let-7i	CLIP-seq
MIRT1968887	hsa-miR-1245b-3p	CLIP-seq
MIRT1968888	hsa-miR-1827	CLIP-seq
MIRT2508344	hsa-miR-3140-5p	CLIP-seq
MIRT1968895	hsa-miR-3179	CLIP-seq
MIRT2508345	hsa-miR-3189-5p	CLIP-seq
MIRT1968896	hsa-miR-3194-5p	CLIP-seq
MIRT2508346	hsa-miR-3622a-3p	CLIP-seq
MIRT907265	hsa-miR-3622a-5p	CLIP-seq
MIRT2508347	hsa-miR-3622b-3p	CLIP-seq
MIRT1968897	hsa-miR-3649	CLIP-seq
MIRT1968898	hsa-miR-3671	CLIP-seq
MIRT1968899	hsa-miR-3918	CLIP-seq
MIRT1968900	hsa-miR-3936	CLIP-seq
MIRT1968902	hsa-miR-4280	CLIP-seq
MIRT1968903	hsa-miR-4293	CLIP-seq
MIRT907272	hsa-miR-4423-3p	CLIP-seq
MIRT1968905	hsa-miR-4458	CLIP-seq
MIRT1968906	hsa-miR-4459	CLIP-seq
MIRT1968907	hsa-miR-4469	CLIP-seq
MIRT2508348	hsa-miR-4488	CLIP-seq
MIRT1968908	hsa-miR-4500	CLIP-seq
MIRT1968909	hsa-miR-4640-5p	CLIP-seq
MIRT1968911	hsa-miR-4645-3p	CLIP-seq
MIRT1968912	hsa-miR-4649-3p	CLIP-seq
MIRT2508349	hsa-miR-4680-3p	CLIP-seq
MIRT1968914	hsa-miR-4685-5p	CLIP-seq
MIRT2508350	hsa-miR-4697-5p	CLIP-seq
MIRT2204953	hsa-miR-4715-3p	CLIP-seq
MIRT907283	hsa-miR-4722-5p	CLIP-seq
MIRT1968916	hsa-miR-4726-5p	CLIP-seq
MIRT2508351	hsa-miR-4758-3p	CLIP-seq
MIRT1968922	hsa-miR-544b	CLIP-seq
MIRT1968925	hsa-miR-607	CLIP-seq
MIRT1968929	hsa-miR-98	CLIP-seq
MIRT1968876	hsa-let-7a	CLIP-seq
MIRT1968877	hsa-let-7b	CLIP-seq
MIRT1968878	hsa-let-7c	CLIP-seq
MIRT1968879	hsa-let-7d	CLIP-seq
MIRT1968880	hsa-let-7e	CLIP-seq
MIRT1968881	hsa-let-7f	CLIP-seq
MIRT1968882	hsa-let-7g	CLIP-seq
MIRT1968883	hsa-let-7i	CLIP-seq
MIRT1968887	hsa-miR-1245b-3p	CLIP-seq
MIRT907250	hsa-miR-145	CLIP-seq
MIRT1968888	hsa-miR-1827	CLIP-seq
MIRT907253	hsa-miR-214	CLIP-seq
MIRT1968893	hsa-miR-2276	CLIP-seq
MIRT2508344	hsa-miR-3140-5p	CLIP-seq
MIRT907260	hsa-miR-3159	CLIP-seq
MIRT1968895	hsa-miR-3179	CLIP-seq
MIRT2508345	hsa-miR-3189-5p	CLIP-seq
MIRT1968896	hsa-miR-3194-5p	CLIP-seq
MIRT907264	hsa-miR-3619-5p	CLIP-seq
MIRT2508346	hsa-miR-3622a-3p	CLIP-seq
MIRT907265	hsa-miR-3622a-5p	CLIP-seq
MIRT2508347	hsa-miR-3622b-3p	CLIP-seq
MIRT1968897	hsa-miR-3649	CLIP-seq
MIRT1968898	hsa-miR-3671	CLIP-seq
MIRT1968899	hsa-miR-3918	CLIP-seq
MIRT907268	hsa-miR-3925-3p	CLIP-seq
MIRT1968900	hsa-miR-3936	CLIP-seq
MIRT1968902	hsa-miR-4280	CLIP-seq
MIRT907271	hsa-miR-4291	CLIP-seq
MIRT1968903	hsa-miR-4293	CLIP-seq
MIRT907272	hsa-miR-4423-3p	CLIP-seq
MIRT907274	hsa-miR-4436b-3p	CLIP-seq
MIRT1968905	hsa-miR-4458	CLIP-seq
MIRT1968906	hsa-miR-4459	CLIP-seq
MIRT1968907	hsa-miR-4469	CLIP-seq
MIRT2508348	hsa-miR-4488	CLIP-seq
MIRT1968908	hsa-miR-4500	CLIP-seq
MIRT1968909	hsa-miR-4640-5p	CLIP-seq
MIRT1968911	hsa-miR-4645-3p	CLIP-seq
MIRT1968912	hsa-miR-4649-3p	CLIP-seq
MIRT2508349	hsa-miR-4680-3p	CLIP-seq
MIRT1968914	hsa-miR-4685-5p	CLIP-seq
MIRT2508350	hsa-miR-4697-5p	CLIP-seq
MIRT2204953	hsa-miR-4715-3p	CLIP-seq
MIRT907283	hsa-miR-4722-5p	CLIP-seq
MIRT1968916	hsa-miR-4726-5p	CLIP-seq
MIRT2508351	hsa-miR-4758-3p	CLIP-seq
MIRT1968918	hsa-miR-4762-5p	CLIP-seq
MIRT1968919	hsa-miR-4772-3p	CLIP-seq
MIRT907288	hsa-miR-508-5p	CLIP-seq
MIRT1968922	hsa-miR-544b	CLIP-seq
MIRT1968923	hsa-miR-548n	CLIP-seq
MIRT1968924	hsa-miR-548t	CLIP-seq
MIRT1968925	hsa-miR-607	CLIP-seq
MIRT907291	hsa-miR-651	CLIP-seq
MIRT907293	hsa-miR-761	CLIP-seq
MIRT1968928	hsa-miR-891b	CLIP-seq
MIRT907294	hsa-miR-922	CLIP-seq
MIRT1968929	hsa-miR-98	CLIP-seq

13 Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 18725644, 19136632, 25416956, 26496610, 28169297, 32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005847	Component	MRNA cleavage and polyadenylation specificity factor complex	IBA
GO:0005847	Component	MRNA cleavage and polyadenylation specificity factor complex	IDA	21102410
GO:0006397	Process	MRNA processing	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
603052	2327	ENSG00000160917

O95639

Protein name

Cleavage and polyadenylation specificity factor subunit 4 (Cleavage and polyadenylation specificity factor 30 kDa subunit) (CPSF 30 kDa subunit) (NS1 effector domain-binding protein 1) (Neb-1) (No arches homolog)

Protein function

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cl

PDB

2D9N , 2RHK , 6DNH , 6FUW , 6URG , 6URO , 7K95 , 7ZYH , 8E3I , 8E3Q , 8R8R

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00098	zf-CCHC	243 → 260	Zinc knuckle	Domain
PF00642	zf-CCCH	143 → 168	Zinc finger C-x8-C-x5-C-x3-H type (and similar)	Family
PF15663	zf-CCCH_3	33 → 121	Zinc-finger containing family	Family

Sequence

MQEIIASVDHIKFDLEIAVEQQLGAQPLPFPGMDKSGAAVCEFFLKAACGKGGMCPFRHI
SGEKTVVCKHWLRGLCKKGDQCEFLHEYDMTKMPECYFYSKFGECSNKECPFLHIDPESK
IKDCPWYDRGFCKHGPLCRHRHTRRVICVNYLVGFCPEGPSCKFMHPRFELPMGTTEQPP
LPQQTQPPAKQSNNPPLQRSSSLIQLTSQNSSPNQQRTPQVIGVMQSQNSSAGNRGPRPL
EQVTCYKCGEKGHYANRCTKGHLAFLSGQ

Sequence length

269

Interactions

View interactions

KEGG Pathway	Reactome Pathway
mRNA surveillance pathway	Transport of Mature mRNA Derived from an Intronless Transcript
Influenza A	Inhibition of Host mRNA Processing and RNA Silencing
	tRNA processing in the nucleus
	mRNA Splicing - Major Pathway
	mRNA 3'-end processing
	RNA Polymerase II Transcription Termination
	Processing of Intronless Pre-mRNAs

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal. Show/Hide Unknown Diseases (22)
Acute myeloid leukemia	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Adrenocortical carcinoma, hereditary	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cholangiocarcinoma	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Chronic lymphocytic leukemia/small lymphocytic lymphoma	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial pancreatic carcinoma	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lymphoma	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian cancer	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uveal melanoma	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (28)
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	24358221, 24618080, 26628108		★★★★★ ★☆☆☆☆ Found in Text Mining only
Allergic rhinitis (disorder)	Allergic rhinitis	BEFREE	17040605, 30612129		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anxiety Disorders	Anxiety Disorder	BEFREE	31580502		★★★★★ ★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	BEFREE	30685779		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	30970220		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	24358221, 24618080, 26628108, 27450326, 31301362		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	37841237	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	31301362		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	27997899, 31301362		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	27997899	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	BEFREE	30886197		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	29852394		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	29852394		★★★★★ ★☆☆☆☆ Found in Text Mining only
Eosinophilia	Eosinophilia	BEFREE	29661061		★★★★★ ★☆☆☆☆ Found in Text Mining only
Epidermolysis Bullosa Simplex	Epidermolysis Bullosa Simplex	BEFREE	12890194		★★★★★ ★☆☆☆☆ Found in Text Mining only
Gastroesophageal reflux disease	Gastroesophageal Reflux Disease	BEFREE	28906377		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	24358221, 26628108	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	BEFREE	27450326, 30970220		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	30970220		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	24358221, 24618080, 26628108, 27450326, 30970220, 31301362		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	24358221, 31466918		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	31301362		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial Infarction	BEFREE	9327770		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	24358221, 24618080, 27450326		★★★★★ ★☆☆☆☆ Found in Text Mining only
PAROXYSMAL EXTREME PAIN DISORDER	Paroxysmal extreme pain disorder	BEFREE	21115638		★★★★★ ★☆☆☆☆ Found in Text Mining only
Personality Disorders	Personality Disorders	BEFREE	31580502		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	37629142	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	39731153	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
CPSF1	[]	7	["mRNA surveillance pathway","mRNA Splicing - Major Pathway","Transport of Mature mRNA Derived from an Intronless Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination","tRNA processing in the nucleus","Processing of Intronless Pre-mRNAs"]	[]
PABPN1	[]	7	["mRNA surveillance pathway","Influenza A","mRNA Splicing - Major Pathway","mRNA 3'-end processing","RNA Polymerase II Transcription Termination","Inhibition of Host mRNA Processing and RNA Silencing","Processing of Intronless Pre-mRNAs"]	[]
CLP1	[]	6	["mRNA surveillance pathway","mRNA Splicing - Major Pathway","mRNA 3'-end processing","RNA Polymerase II Transcription Termination","tRNA processing in the nucleus","Processing of Intronless Pre-mRNAs"]	[]
CSTF2	[]	6	["mRNA surveillance pathway","mRNA Splicing - Major Pathway","mRNA 3'-end processing","RNA Polymerase II Transcription Termination","tRNA processing in the nucleus","Processing of Intronless Pre-mRNAs"]	[]
CPSF3	[]	6	["mRNA surveillance pathway","mRNA Splicing - Major Pathway","Transport of Mature mRNA Derived from an Intronless Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination","Processing of Intronless Pre-mRNAs"]	[]

CPSF4 (cleavage and polyadenylation specific factor 4)

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