CPNE8 (copine 8)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 144402
• Gene name: Copine 8
• Gene symbol: CPNE8
• Synonyms (NCBI Gene): -
• Chromosome: 12
• Chromosome location: 12q12
• Summary: Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an in

miRNA Show/Hide all (119)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005134	hsa-miR-30a-5p	pSILAC	18668040
MIRT022217	hsa-miR-124-3p	Microarray	18668037
MIRT005134	hsa-miR-30a-5p	Proteomics;Other	18668040
MIRT051072	hsa-miR-16-5p	CLASH	23622248
MIRT704491	hsa-miR-8485	HITS-CLIP	23313552
MIRT704492	hsa-miR-4719	HITS-CLIP	23313552
MIRT704491	hsa-miR-8485	HITS-CLIP	23313552
MIRT704492	hsa-miR-4719	HITS-CLIP	23313552
MIRT906762	hsa-miR-224	CLIP-seq
MIRT906763	hsa-miR-30a	CLIP-seq
MIRT906764	hsa-miR-30b	CLIP-seq
MIRT906765	hsa-miR-30c	CLIP-seq
MIRT906766	hsa-miR-30d	CLIP-seq
MIRT906767	hsa-miR-30e	CLIP-seq
MIRT906768	hsa-miR-3148	CLIP-seq
MIRT906769	hsa-miR-3163	CLIP-seq
MIRT906770	hsa-miR-340	CLIP-seq
MIRT906771	hsa-miR-3620	CLIP-seq
MIRT906772	hsa-miR-4251	CLIP-seq
MIRT906773	hsa-miR-4477a	CLIP-seq
MIRT906774	hsa-miR-4495	CLIP-seq
MIRT906775	hsa-miR-4503	CLIP-seq
MIRT906776	hsa-miR-539	CLIP-seq
MIRT906777	hsa-miR-548ac	CLIP-seq
MIRT906778	hsa-miR-548d-3p	CLIP-seq
MIRT906779	hsa-miR-548n	CLIP-seq
MIRT906780	hsa-miR-548t	CLIP-seq
MIRT906781	hsa-miR-548z	CLIP-seq
MIRT906782	hsa-miR-802	CLIP-seq
MIRT906783	hsa-miR-944	CLIP-seq
MIRT906769	hsa-miR-3163	CLIP-seq
MIRT906770	hsa-miR-340	CLIP-seq
MIRT1968719	hsa-miR-3653	CLIP-seq
MIRT1968720	hsa-miR-3658	CLIP-seq
MIRT1968721	hsa-miR-4511	CLIP-seq
MIRT1968722	hsa-miR-4773	CLIP-seq
MIRT1968723	hsa-miR-548b-3p	CLIP-seq
MIRT1968724	hsa-miR-642b	CLIP-seq
MIRT2386418	hsa-miR-188-5p	CLIP-seq
MIRT2386419	hsa-miR-204	CLIP-seq
MIRT2386420	hsa-miR-211	CLIP-seq
MIRT2386421	hsa-miR-335	CLIP-seq
MIRT2386422	hsa-miR-4676-5p	CLIP-seq
MIRT2386423	hsa-miR-575	CLIP-seq
MIRT2447529	hsa-miR-3145-3p	CLIP-seq
MIRT2447530	hsa-miR-513a-3p	CLIP-seq
MIRT2508178	hsa-miR-1302	CLIP-seq
MIRT2508179	hsa-miR-1324	CLIP-seq
MIRT2508180	hsa-miR-137	CLIP-seq
MIRT2508181	hsa-miR-145	CLIP-seq
MIRT2508182	hsa-miR-190	CLIP-seq
MIRT2508183	hsa-miR-190b	CLIP-seq
MIRT2508184	hsa-miR-198	CLIP-seq
MIRT2386419	hsa-miR-204	CLIP-seq
MIRT2386420	hsa-miR-211	CLIP-seq
MIRT906762	hsa-miR-224	CLIP-seq
MIRT2508185	hsa-miR-2355-3p	CLIP-seq
MIRT2508186	hsa-miR-25	CLIP-seq
MIRT2508187	hsa-miR-299-3p	CLIP-seq
MIRT2508188	hsa-miR-3121-3p	CLIP-seq
MIRT2508189	hsa-miR-3122	CLIP-seq
MIRT2508190	hsa-miR-3124-3p	CLIP-seq
MIRT906769	hsa-miR-3163	CLIP-seq
MIRT2508191	hsa-miR-3171	CLIP-seq
MIRT2508192	hsa-miR-3180-5p	CLIP-seq
MIRT2508193	hsa-miR-32	CLIP-seq
MIRT906770	hsa-miR-340	CLIP-seq
MIRT906771	hsa-miR-3620	CLIP-seq
MIRT2508194	hsa-miR-363	CLIP-seq
MIRT2508195	hsa-miR-367	CLIP-seq
MIRT2508196	hsa-miR-3691-5p	CLIP-seq
MIRT2508197	hsa-miR-3913-5p	CLIP-seq
MIRT2508198	hsa-miR-4298	CLIP-seq
MIRT2508199	hsa-miR-4311	CLIP-seq
MIRT2508200	hsa-miR-4422	CLIP-seq
MIRT2508201	hsa-miR-4446-5p	CLIP-seq
MIRT2508202	hsa-miR-4491	CLIP-seq
MIRT2508203	hsa-miR-450b-5p	CLIP-seq
MIRT2508204	hsa-miR-452	CLIP-seq
MIRT2508205	hsa-miR-4646-3p	CLIP-seq
MIRT2508206	hsa-miR-4652-3p	CLIP-seq
MIRT2508207	hsa-miR-4657	CLIP-seq
MIRT2508208	hsa-miR-4676-3p	CLIP-seq
MIRT2508209	hsa-miR-4712-5p	CLIP-seq
MIRT2508210	hsa-miR-4729	CLIP-seq
MIRT2508211	hsa-miR-4752	CLIP-seq
MIRT2508212	hsa-miR-4755-5p	CLIP-seq
MIRT2508213	hsa-miR-4764-5p	CLIP-seq
MIRT906779	hsa-miR-548n	CLIP-seq
MIRT906780	hsa-miR-548t	CLIP-seq
MIRT2508214	hsa-miR-570	CLIP-seq
MIRT2508215	hsa-miR-581	CLIP-seq
MIRT2508216	hsa-miR-623	CLIP-seq
MIRT2508217	hsa-miR-770-5p	CLIP-seq
MIRT2508218	hsa-miR-92a	CLIP-seq
MIRT2508219	hsa-miR-92b	CLIP-seq
MIRT2508179	hsa-miR-1324	CLIP-seq
MIRT2508180	hsa-miR-137	CLIP-seq
MIRT2508184	hsa-miR-198	CLIP-seq
MIRT2386419	hsa-miR-204	CLIP-seq
MIRT2386420	hsa-miR-211	CLIP-seq
MIRT2508185	hsa-miR-2355-3p	CLIP-seq
MIRT2508186	hsa-miR-25	CLIP-seq
MIRT2508188	hsa-miR-3121-3p	CLIP-seq
MIRT2508193	hsa-miR-32	CLIP-seq
MIRT2508194	hsa-miR-363	CLIP-seq
MIRT2508195	hsa-miR-367	CLIP-seq
MIRT2508199	hsa-miR-4311	CLIP-seq
MIRT2508200	hsa-miR-4422	CLIP-seq
MIRT2508201	hsa-miR-4446-5p	CLIP-seq
MIRT2508203	hsa-miR-450b-5p	CLIP-seq
MIRT2508205	hsa-miR-4646-3p	CLIP-seq
MIRT2508206	hsa-miR-4652-3p	CLIP-seq
MIRT2508210	hsa-miR-4729	CLIP-seq
MIRT2508212	hsa-miR-4755-5p	CLIP-seq
MIRT2508215	hsa-miR-581	CLIP-seq
MIRT2508216	hsa-miR-623	CLIP-seq
MIRT2508218	hsa-miR-92a	CLIP-seq
MIRT2508219	hsa-miR-92b	CLIP-seq

Gene ontology (GO) Show/Hide all (8)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005544	Function	Calcium-dependent phospholipid binding	IBA
GO:0005544	Function	Calcium-dependent phospholipid binding	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337, 23533145
GO:0071277	Process	Cellular response to calcium ion	IBA
GO:1903861	Process	Positive regulation of dendrite extension	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q86YQ8
• Protein name: Copine-8 (Copine VIII)
• Protein function: Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00168	C2	159 → 267	C2 domain	Domain
  PF00168	C2	25 → 135	C2 domain	Domain
  PF07002	Copine	328 → 547	Copine	Family

• Sequence:

  MDSRYNSTAGIGDLNQLSAAIPATRVEVSVSCRNLLDRDTFSKSDPICVLYVQGVGNKEW
  REFGRTEVIDNTLNPDFVRKFILDYFFEERENLRFDLYDVDSKSPNLSKHDFLGQVFCTL
  GEIVGSQGSRLEKPIVGIPGKKCGTIILTAEELNCCRDAVLMQFCANKLDKKDFFGKSDP
  FLVFYRSNEDGSFTICHKTEVVKNTLNPVWQAFKISVRALCNGDYDRTIKVEVYDWDRDG
  SHDFIGEFTTSYRELSRGQSQFNVYEVVNPKKKGKKKKYTNSGTVTLLSFLVETEVSFLD
  YIKGGTQINFTVAIDFTASNGNPAQPTSLHYMNPYQLNAYGMALKAVGEIVQDYDSDKMF
  PALGFGAKLPPDGRISHEFALNGNPQNPYCDGIEGVMEAYYRSLKSVQLYGPTNFAPVIN
  HVARYASSVKDGSQYFVLLIVTDGVISDMAQTKESIVNASKLPMSIIIVGVGPAEFDAMV
  ELDGDDVRVSSRGKYAERDIVQFVPFRDYIDRSGNHILSMARLAKDVLAEIPEQFLSYMR
  ARGIKPSPAPPPYTPPTHVLQTQI

• Sequence length: 564

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ATYPICAL FEMORAL FRACTURE	—	GWAS catalog	31006051	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	28115744	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (7)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Arthrogryposis	Arthrogryposis multiplex congenita	BEFREE	16734683		★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar Disorder	GWASCAT_DG	28115744		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Breast Neoplasms	Breast neoplasm	Pubtator	27081041	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	31487856	Associate	★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	33780365	Associate	★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	35409173	Associate	★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	34663825, 35982908	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for CPNE8.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to CPNE8.