CPLX3 (complexin 3)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 594855
• Gene name: Complexin 3
• Gene symbol: CPLX3
• Synonyms (NCBI Gene): CPX-III, CPXIII, Nbla11589
• Chromosome: 15
• Chromosome location: 15q24.1

miRNA Show/Hide all (52)

miRTarBase ID	miRNA	Experiments	Reference
MIRT906342	hsa-miR-1231	CLIP-seq
MIRT906343	hsa-miR-1254	CLIP-seq
MIRT906344	hsa-miR-1909	CLIP-seq
MIRT906345	hsa-miR-2278	CLIP-seq
MIRT906346	hsa-miR-24	CLIP-seq
MIRT906347	hsa-miR-296-5p	CLIP-seq
MIRT906348	hsa-miR-3116	CLIP-seq
MIRT906349	hsa-miR-3184	CLIP-seq
MIRT906350	hsa-miR-3652	CLIP-seq
MIRT906351	hsa-miR-3919	CLIP-seq
MIRT906352	hsa-miR-423-5p	CLIP-seq
MIRT906353	hsa-miR-4254	CLIP-seq
MIRT906354	hsa-miR-4292	CLIP-seq
MIRT906355	hsa-miR-4308	CLIP-seq
MIRT906356	hsa-miR-4430	CLIP-seq
MIRT906357	hsa-miR-4492	CLIP-seq
MIRT906358	hsa-miR-4498	CLIP-seq
MIRT906359	hsa-miR-4638-3p	CLIP-seq
MIRT906360	hsa-miR-4695-5p	CLIP-seq
MIRT906361	hsa-miR-4756-3p	CLIP-seq
MIRT906362	hsa-miR-498	CLIP-seq
MIRT906363	hsa-miR-514	CLIP-seq
MIRT906364	hsa-miR-514b-3p	CLIP-seq
MIRT906365	hsa-miR-516b	CLIP-seq
MIRT906366	hsa-miR-548m	CLIP-seq
MIRT906367	hsa-miR-603	CLIP-seq
MIRT906368	hsa-miR-642b	CLIP-seq
MIRT906369	hsa-miR-762	CLIP-seq
MIRT1968636	hsa-miR-3120-5p	CLIP-seq
MIRT1968637	hsa-miR-4438	CLIP-seq
MIRT2204722	hsa-miR-1245b-3p	CLIP-seq
MIRT2204723	hsa-miR-1265	CLIP-seq
MIRT2204724	hsa-miR-1272	CLIP-seq
MIRT2204725	hsa-miR-2392	CLIP-seq
MIRT906354	hsa-miR-4292	CLIP-seq
MIRT906355	hsa-miR-4308	CLIP-seq
MIRT906363	hsa-miR-514	CLIP-seq
MIRT906364	hsa-miR-514b-3p	CLIP-seq
MIRT906367	hsa-miR-603	CLIP-seq
MIRT906368	hsa-miR-642b	CLIP-seq
MIRT906354	hsa-miR-4292	CLIP-seq
MIRT906355	hsa-miR-4308	CLIP-seq
MIRT906363	hsa-miR-514	CLIP-seq
MIRT906364	hsa-miR-514b-3p	CLIP-seq
MIRT906367	hsa-miR-603	CLIP-seq
MIRT906368	hsa-miR-642b	CLIP-seq
MIRT2447507	hsa-miR-1224-3p	CLIP-seq
MIRT2447508	hsa-miR-4323	CLIP-seq
MIRT2508134	hsa-miR-342-3p	CLIP-seq
MIRT2508135	hsa-miR-377	CLIP-seq
MIRT2508134	hsa-miR-342-3p	CLIP-seq
MIRT2508135	hsa-miR-377	CLIP-seq

Gene ontology (GO) Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000149	Function	SNARE binding	IBA
GO:0000149	Function	SNARE binding	IEA
GO:0005326	Function	Neurotransmitter transmembrane transporter activity	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0006836	Process	Neurotransmitter transport	IEA
GO:0006887	Process	Exocytosis	IEA
GO:0007601	Process	Visual perception	IEA
GO:0016020	Component	Membrane	IEA
GO:0016079	Process	Synaptic vesicle exocytosis	IBA
GO:0016079	Process	Synaptic vesicle exocytosis	IEA
GO:0019905	Function	Syntaxin binding	IEA
GO:0030073	Process	Insulin secretion	IEA
GO:0030672	Component	Synaptic vesicle membrane	IEA
GO:0031201	Component	SNARE complex	IBA
GO:0031630	Process	Regulation of synaptic vesicle fusion to presynaptic active zone membrane	IBA
GO:0031630	Process	Regulation of synaptic vesicle fusion to presynaptic active zone membrane	IEA
GO:0043195	Component	Terminal bouton	IBA
GO:0045202	Component	Synapse	IEA
GO:0046928	Process	Regulation of neurotransmitter secretion	IEA
GO:0048787	Component	Presynaptic active zone membrane	IEA
GO:0050804	Process	Modulation of chemical synaptic transmission	IBA
GO:0098684	Component	Photoreceptor ribbon synapse	IEA

Other IDs

• MIM: 609585
• HGNC: 27652
• e!Ensembl: ENSG00000213578

Protein

• UniProt ID: Q8WVH0
• Protein name: Complexin-3 (Complexin III) (CPX III)
• Protein function: Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity). Required for the maintenance of synaptic ultrastructure in the adult retina (By similarity). Positively regulates synaptic transmission through syna
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05835	Synaphin	1 → 139	Synaphin protein	Family

• Sequence:

  MAFMVKTMVGGQLKNLTGSLGGGEDKGDGDKSAAEAQGMSREEYEEYQKQLVEEKMERDA
  QFTQRKAERATLRSHFRDKYRLPKNETDESQIQMAGGDVELPRELAKMIEEDTEEEEEKA
  SVLGQLASLPGLNLGSLKDKAQATLGDLKQSAEKCHVM

• Sequence length: 158

Pathways

KEGG Pathway:

Synaptic vesicle cycle

Related Genes

No strongly related genes found yet for CPLX3.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to CPLX3.