COX6C (cytochrome c oxidase subunit 6C)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 1345
• Gene name: Cytochrome c oxidase subunit 6C
• Gene symbol: COX6C
• Synonyms (NCBI Gene): -
• Chromosome: 8
• Chromosome location: 8q22.2
• Summary: Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multip

miRNA Show/Hide all (75)

miRTarBase ID	miRNA	Experiments	Reference
MIRT905493	hsa-miR-2053	CLIP-seq
MIRT905494	hsa-miR-3125	CLIP-seq
MIRT905495	hsa-miR-3185	CLIP-seq
MIRT905496	hsa-miR-335	CLIP-seq
MIRT905497	hsa-miR-3607-5p	CLIP-seq
MIRT905498	hsa-miR-3916	CLIP-seq
MIRT905499	hsa-miR-3928	CLIP-seq
MIRT905500	hsa-miR-4272	CLIP-seq
MIRT905501	hsa-miR-4276	CLIP-seq
MIRT905502	hsa-miR-4504	CLIP-seq
MIRT905503	hsa-miR-4697-3p	CLIP-seq
MIRT905504	hsa-miR-4714-3p	CLIP-seq
MIRT905505	hsa-miR-4731-3p	CLIP-seq
MIRT905506	hsa-miR-4760-3p	CLIP-seq
MIRT905507	hsa-miR-4801	CLIP-seq
MIRT905508	hsa-miR-569	CLIP-seq
MIRT905509	hsa-miR-592	CLIP-seq
MIRT905510	hsa-miR-597	CLIP-seq
MIRT905511	hsa-miR-664	CLIP-seq
MIRT905512	hsa-miR-873	CLIP-seq
MIRT905494	hsa-miR-3125	CLIP-seq
MIRT905496	hsa-miR-335	CLIP-seq
MIRT905498	hsa-miR-3916	CLIP-seq
MIRT905499	hsa-miR-3928	CLIP-seq
MIRT905494	hsa-miR-3125	CLIP-seq
MIRT905496	hsa-miR-335	CLIP-seq
MIRT905497	hsa-miR-3607-5p	CLIP-seq
MIRT905498	hsa-miR-3916	CLIP-seq
MIRT905499	hsa-miR-3928	CLIP-seq
MIRT1968511	hsa-miR-3973	CLIP-seq
MIRT905501	hsa-miR-4276	CLIP-seq
MIRT905502	hsa-miR-4504	CLIP-seq
MIRT1968512	hsa-miR-4693-5p	CLIP-seq
MIRT905503	hsa-miR-4697-3p	CLIP-seq
MIRT905505	hsa-miR-4731-3p	CLIP-seq
MIRT905507	hsa-miR-4801	CLIP-seq
MIRT1968513	hsa-miR-548l	CLIP-seq
MIRT905509	hsa-miR-592	CLIP-seq
MIRT905510	hsa-miR-597	CLIP-seq
MIRT905511	hsa-miR-664	CLIP-seq
MIRT905512	hsa-miR-873	CLIP-seq
MIRT905497	hsa-miR-3607-5p	CLIP-seq
MIRT905500	hsa-miR-4272	CLIP-seq
MIRT905501	hsa-miR-4276	CLIP-seq
MIRT905502	hsa-miR-4504	CLIP-seq
MIRT905503	hsa-miR-4697-3p	CLIP-seq
MIRT905504	hsa-miR-4714-3p	CLIP-seq
MIRT905505	hsa-miR-4731-3p	CLIP-seq
MIRT905506	hsa-miR-4760-3p	CLIP-seq
MIRT905507	hsa-miR-4801	CLIP-seq
MIRT905509	hsa-miR-592	CLIP-seq
MIRT905510	hsa-miR-597	CLIP-seq
MIRT905512	hsa-miR-873	CLIP-seq
MIRT905511	hsa-miR-664	CLIP-seq
MIRT905512	hsa-miR-873	CLIP-seq
MIRT905493	hsa-miR-2053	CLIP-seq
MIRT905495	hsa-miR-3185	CLIP-seq
MIRT1968511	hsa-miR-3973	CLIP-seq
MIRT905500	hsa-miR-4272	CLIP-seq
MIRT1968512	hsa-miR-4693-5p	CLIP-seq
MIRT905504	hsa-miR-4714-3p	CLIP-seq
MIRT905506	hsa-miR-4760-3p	CLIP-seq
MIRT2507897	hsa-miR-539	CLIP-seq
MIRT1968513	hsa-miR-548l	CLIP-seq
MIRT2507898	hsa-miR-548u	CLIP-seq
MIRT905508	hsa-miR-569	CLIP-seq
MIRT905495	hsa-miR-3185	CLIP-seq
MIRT1968511	hsa-miR-3973	CLIP-seq
MIRT905500	hsa-miR-4272	CLIP-seq
MIRT1968512	hsa-miR-4693-5p	CLIP-seq
MIRT905504	hsa-miR-4714-3p	CLIP-seq
MIRT905506	hsa-miR-4760-3p	CLIP-seq
MIRT2507897	hsa-miR-539	CLIP-seq
MIRT1968513	hsa-miR-548l	CLIP-seq
MIRT2507898	hsa-miR-548u	CLIP-seq

Gene ontology (GO) Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	17500595, 32296183, 32814053
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IBA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0005758	Component	Mitochondrial intermembrane space	TAS
GO:0006091	Process	Generation of precursor metabolites and energy	TAS	2849755
GO:0006119	Process	Oxidative phosphorylation	IEA
GO:0006123	Process	Mitochondrial electron transport, cytochrome c to oxygen	NAS	30030519
GO:0016020	Component	Membrane	IEA
GO:0031966	Component	Mitochondrial membrane	IDA	30030519
GO:0045277	Component	Respiratory chain complex IV	IEA
GO:0045333	Process	Cellular respiration	NAS	30030519

Other IDs

• MIM: 124090
• HGNC: 2285
• e!Ensembl: ENSG00000164919

Protein

• UniProt ID: P09669
• Protein name: Cytochrome c oxidase subunit 6C (Cytochrome c oxidase polypeptide VIc)
• Protein function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiqu
• PDB: 5Z62
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02937	COX6C	5 → 74	Cytochrome c oxidase subunit VIc	Family

• Sequence:

  MAPEVLPKPRMRGLLARRLRNHMAVAFVLSLGVAALYKFRVADQRKKAYADFYRNYDVMK
  DFEEMRKAGIFQSVK

• Sequence length: 75

Pathways

KEGG Pathway	Reactome Pathway
Oxidative phosphorylation	TP53 Regulates Metabolic Genes
Metabolic pathways	Respiratory electron transport
Cardiac muscle contraction
Thermogenesis
Non-alcoholic fatty liver disease
Alzheimer disease
Parkinson disease
Amyotrophic lateral sclerosis
Huntington disease
Prion disease
Pathways of neurodegeneration - multiple diseases
Chemical carcinogenesis - reactive oxygen species
Diabetic cardiomyopathy

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
LUNG ADENOCARCINOMA	—	GWAS catalog	40829600	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CANCER	—	GWAS catalog	40829600	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA	—	GWAS catalog	40829600	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL CARCINOMA	—	GWAS catalog	40829600	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (17)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Carcinoma	Breast Carcinoma	BEFREE	31497264		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	33318294	Stimulate	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	36594618, 37510369	Associate	★☆☆☆☆ Found in Text Mining only
Cognitive Dysfunction	Cognition disorder	Pubtator	38242874	Associate	★☆☆☆☆ Found in Text Mining only
Cohen syndrome	Cohen Syndrome	CLINVAR_DG	15141358, 19006247, 20461111, 27533158		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 1	Diabetes mellitus, type 1	Pubtator	33083497	Associate	★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophageal neoplasm	Pubtator	38196829	Associate	★☆☆☆☆ Found in Text Mining only
Intracranial Aneurysm	Intracranial aneurysm	Pubtator	36451838	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	31497264		★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	31497264		★☆☆☆☆ Found in Text Mining only
Metabolic Syndrome	Metabolic syndrome	Pubtator	34714849	Associate	★☆☆☆☆ Found in Text Mining only
Mitochondrial Diseases	Mitochondrial disease	Pubtator	38242874	Stimulate	★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	34623759, 36551283	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	11943344		★☆☆☆☆ Found in Text Mining only
Peritonitis	Peritonitis	Pubtator	24204994	Inhibit	★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	37482618	Associate	★☆☆☆☆ Found in Text Mining only
Uterine Fibroids	Uterine Fibroids	BEFREE	10679920		★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

COX4I1 10 shared pathwaysOxidative phosphorylation, Cardiac muscle contraction, Thermogenesis, Non-alcoholic fatty liver disease, Parkinson disease, Prion disease, Chemical carcinogenesis - reactive oxygen species, Diabetic cardiomyopathy, TP53 Regulates Metabolic Genes, Respiratory electron transport Related via 10 shared pathways including Oxidative phosphorylation, Cardiac muscle contraction. COX5B 10 shared pathwaysOxidative phosphorylation, Cardiac muscle contraction, Thermogenesis, Non-alcoholic fatty liver disease, Parkinson disease, Prion disease, Chemical carcinogenesis - reactive oxygen species, Diabetic cardiomyopathy, TP53 Regulates Metabolic Genes, Respiratory electron transport Related via 10 shared pathways including Oxidative phosphorylation, Cardiac muscle contraction. COX6A1 10 shared pathwaysOxidative phosphorylation, Cardiac muscle contraction, Thermogenesis, Non-alcoholic fatty liver disease, Parkinson disease, Prion disease, Chemical carcinogenesis - reactive oxygen species, Diabetic cardiomyopathy, TP53 Regulates Metabolic Genes, Respiratory electron transport Related via 10 shared pathways including Oxidative phosphorylation, Cardiac muscle contraction. COX6B1 10 shared pathwaysOxidative phosphorylation, Cardiac muscle contraction, Thermogenesis, Non-alcoholic fatty liver disease, Parkinson disease, Prion disease, Chemical carcinogenesis - reactive oxygen species, Diabetic cardiomyopathy, TP53 Regulates Metabolic Genes, Respiratory electron transport Related via 10 shared pathways including Oxidative phosphorylation, Cardiac muscle contraction. COX7B 10 shared pathwaysOxidative phosphorylation, Cardiac muscle contraction, Thermogenesis, Non-alcoholic fatty liver disease, Parkinson disease, Prion disease, Chemical carcinogenesis - reactive oxygen species, Diabetic cardiomyopathy, TP53 Regulates Metabolic Genes, Respiratory electron transport Related via 10 shared pathways including Oxidative phosphorylation, Cardiac muscle contraction.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
COX4I1	0	[]	10	["Oxidative phosphorylation","Cardiac muscle contraction","Thermogenesis","Non-alcoholic fatty liver disease","Parkinson disease","Prion disease","Chemical carcinogenesis - reactive oxygen species","Diabetic cardiomyopathy","TP53 Regulates Metabolic Genes","Respiratory electron transport"]	0	[]
COX5B	0	[]	10	["Oxidative phosphorylation","Cardiac muscle contraction","Thermogenesis","Non-alcoholic fatty liver disease","Parkinson disease","Prion disease","Chemical carcinogenesis - reactive oxygen species","Diabetic cardiomyopathy","TP53 Regulates Metabolic Genes","Respiratory electron transport"]	0	[]
COX6A1	0	[]	10	["Oxidative phosphorylation","Cardiac muscle contraction","Thermogenesis","Non-alcoholic fatty liver disease","Parkinson disease","Prion disease","Chemical carcinogenesis - reactive oxygen species","Diabetic cardiomyopathy","TP53 Regulates Metabolic Genes","Respiratory electron transport"]	0	[]
COX6B1	0	[]	10	["Oxidative phosphorylation","Cardiac muscle contraction","Thermogenesis","Non-alcoholic fatty liver disease","Parkinson disease","Prion disease","Chemical carcinogenesis - reactive oxygen species","Diabetic cardiomyopathy","TP53 Regulates Metabolic Genes","Respiratory electron transport"]	0	[]
COX7B	0	[]	10	["Oxidative phosphorylation","Cardiac muscle contraction","Thermogenesis","Non-alcoholic fatty liver disease","Parkinson disease","Prion disease","Chemical carcinogenesis - reactive oxygen species","Diabetic cardiomyopathy","TP53 Regulates Metabolic Genes","Respiratory electron transport"]	0	[]

Diseases Linked via Similar Genes

Mitochondrial disease Linked via 4 of 5 related genesCOX4I1, COX6A1, COX6B1, COX7B Cytochrome c oxidase deficiency Linked via 2 of 5 related genesCOX4I1, COX6B1 Mitochondrial complex deficiency Linked via 2 of 5 related genesCOX4I1, COX6B1 Leigh syndrome Linked via 1 of 5 related genesCOX4I1 Myocardial ischemia Linked via 1 of 5 related genesCOX5B

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Mitochondrial disease	4	["COX4I1","COX6A1","COX6B1","COX7B"]
Cytochrome c oxidase deficiency	2	["COX4I1","COX6B1"]
Mitochondrial complex deficiency	2	["COX4I1","COX6B1"]
Leigh syndrome	1	["COX4I1"]
Myocardial ischemia	1	["COX5B"]