COMMD6 (COMM domain containing 6)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 170622
• Gene name: COMM domain containing 6
• Gene symbol: COMMD6
• Synonyms (NCBI Gene): Acrg
• Chromosome: 13
• Chromosome location: 13q22.2
• Summary: COMMD6 belongs to a family of NF-kappa-B (see RELA; MIM 164014)-inhibiting proteins characterized by the presence of a COMM domain (see COMMD1; MIM 607238) (de Bie et al., 2006 [PubMed 16573520]).[supplied by OMIM, Mar 2009]

miRNA Show/Hide all (65)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020456	hsa-miR-106b-5p	Microarray	17242205
MIRT527247	hsa-miR-95-5p	PAR-CLIP	22012620
MIRT527246	hsa-miR-6501-5p	PAR-CLIP	22012620
MIRT527245	hsa-miR-4423-5p	PAR-CLIP	22012620
MIRT069003	hsa-miR-1298-5p	PAR-CLIP	22012620
MIRT527244	hsa-miR-744-3p	PAR-CLIP	22012620
MIRT527243	hsa-miR-335-3p	PAR-CLIP	22012620
MIRT527247	hsa-miR-95-5p	PAR-CLIP	22012620
MIRT527246	hsa-miR-6501-5p	PAR-CLIP	22012620
MIRT527245	hsa-miR-4423-5p	PAR-CLIP	22012620
MIRT069003	hsa-miR-1298-5p	PAR-CLIP	22012620
MIRT527244	hsa-miR-744-3p	PAR-CLIP	22012620
MIRT527243	hsa-miR-335-3p	PAR-CLIP	22012620
MIRT903528	hsa-miR-142-5p	CLIP-seq
MIRT903529	hsa-miR-181a	CLIP-seq
MIRT903530	hsa-miR-181b	CLIP-seq
MIRT903531	hsa-miR-181c	CLIP-seq
MIRT903532	hsa-miR-181d	CLIP-seq
MIRT903533	hsa-miR-340	CLIP-seq
MIRT903534	hsa-miR-3609	CLIP-seq
MIRT903535	hsa-miR-4262	CLIP-seq
MIRT903536	hsa-miR-4422	CLIP-seq
MIRT903537	hsa-miR-4719	CLIP-seq
MIRT903538	hsa-miR-513b	CLIP-seq
MIRT903539	hsa-miR-548ah	CLIP-seq
MIRT903540	hsa-miR-561	CLIP-seq
MIRT903541	hsa-miR-1273d	CLIP-seq
MIRT903542	hsa-miR-1912	CLIP-seq
MIRT903543	hsa-miR-3163	CLIP-seq
MIRT903544	hsa-miR-4464	CLIP-seq
MIRT903545	hsa-miR-4748	CLIP-seq
MIRT903546	hsa-miR-657	CLIP-seq
MIRT1967898	hsa-miR-3924	CLIP-seq
MIRT2203765	hsa-miR-2113	CLIP-seq
MIRT2203766	hsa-miR-218	CLIP-seq
MIRT2203767	hsa-miR-3120-3p	CLIP-seq
MIRT2203768	hsa-miR-3148	CLIP-seq
MIRT2203769	hsa-miR-33a	CLIP-seq
MIRT2203770	hsa-miR-33b	CLIP-seq
MIRT903534	hsa-miR-3609	CLIP-seq
MIRT2203771	hsa-miR-3688-3p	CLIP-seq
MIRT2203772	hsa-miR-3908	CLIP-seq
MIRT2203773	hsa-miR-450b-5p	CLIP-seq
MIRT2203774	hsa-miR-4694-3p	CLIP-seq
MIRT2203775	hsa-miR-507	CLIP-seq
MIRT903539	hsa-miR-548ah	CLIP-seq
MIRT2203776	hsa-miR-548t	CLIP-seq
MIRT2203777	hsa-miR-557	CLIP-seq
MIRT903540	hsa-miR-561	CLIP-seq
MIRT2442084	hsa-miR-4279	CLIP-seq
MIRT2442085	hsa-miR-659	CLIP-seq
MIRT2442086	hsa-miR-9	CLIP-seq
MIRT2506900	hsa-miR-10a	CLIP-seq
MIRT2506901	hsa-miR-10b	CLIP-seq
MIRT2678442	hsa-miR-200b	CLIP-seq
MIRT2678443	hsa-miR-200c	CLIP-seq
MIRT2203772	hsa-miR-3908	CLIP-seq
MIRT2678444	hsa-miR-3920	CLIP-seq
MIRT2678445	hsa-miR-429	CLIP-seq
MIRT2678446	hsa-miR-4318	CLIP-seq
MIRT2678447	hsa-miR-4693-5p	CLIP-seq
MIRT2678448	hsa-miR-520d-5p	CLIP-seq
MIRT2678449	hsa-miR-524-5p	CLIP-seq
MIRT903540	hsa-miR-561	CLIP-seq
MIRT2678450	hsa-miR-892a	CLIP-seq

Gene ontology (GO) Show/Hide all (7)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	15799966, 21778237, 21784977, 23563313, 25355947, 25416956, 26496610, 32296183, 33961781, 35271311, 37172566
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0007165	Process	Signal transduction	IBA
GO:0032088	Process	Negative regulation of NF-kappaB transcription factor activity	IDA	16573520
GO:0051059	Function	NF-kappaB binding	IBA
GO:0051059	Function	NF-kappaB binding	IPI	16573520

Other IDs

• MIM: 612377
• HGNC: 24015
• e!Ensembl: ENSG00000188243

Protein

• UniProt ID: Q7Z4G1
• Protein name: COMM domain-containing protein 6
• Protein function: Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). May modulate ac
• PDB: 8F2R , 8F2U , 8P0W
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07258	COMM_domain	16 → 85	COMM domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous. Expressed in brain, heart, skeletal muscle, lung, pancreas, liver, kidney, small intestine and placenta. {ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:16573520}.
• Sequence:

  MEASSEPPLDAKSDVTNQLVDFQWKLGMAVSSDTCRSLKYPYVAVMLKVADHSGQVKTKC
  FEMTIPQFQNFYRQFKEIAAVIETV

• Sequence length: 85

Pathways

Reactome Pathway:

Neddylation

Related Genes

No strongly related genes found yet for COMMD6.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to COMMD6.