COMMD5 (COMM domain containing 5)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 28991
• Gene name: COMM domain containing 5
• Gene symbol: COMMD5
• Synonyms (NCBI Gene): HCARG, HT002
• Chromosome: 8
• Chromosome location: 8q24.3

miRNA Show/Hide all (121)

miRTarBase ID	miRNA	Experiments	Reference
MIRT453923	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT453938	hsa-miR-3714	PAR-CLIP	20371350
MIRT453937	hsa-miR-3910	PAR-CLIP	20371350
MIRT453936	hsa-miR-365a-3p	PAR-CLIP	20371350
MIRT453935	hsa-miR-365b-3p	PAR-CLIP	20371350
MIRT453934	hsa-miR-5197-3p	PAR-CLIP	20371350
MIRT453933	hsa-miR-5586-3p	PAR-CLIP	20371350
MIRT453932	hsa-miR-1910-3p	PAR-CLIP	20371350
MIRT453931	hsa-miR-6511a-5p	PAR-CLIP	20371350
MIRT453930	hsa-miR-211-3p	PAR-CLIP	20371350
MIRT453928	hsa-miR-4270	PAR-CLIP	20371350
MIRT453929	hsa-miR-4441	PAR-CLIP	20371350
MIRT453927	hsa-miR-6754-5p	PAR-CLIP	20371350
MIRT453926	hsa-miR-298	PAR-CLIP	20371350
MIRT453923	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT453922	hsa-miR-506-3p	PAR-CLIP	20371350
MIRT453921	hsa-miR-4477b	PAR-CLIP	20371350
MIRT453920	hsa-miR-7856-5p	PAR-CLIP	20371350
MIRT453923	hsa-miR-124-3p	PAR-CLIP	23592263
MIRT453938	hsa-miR-3714	PAR-CLIP	23592263
MIRT453937	hsa-miR-3910	PAR-CLIP	23592263
MIRT453936	hsa-miR-365a-3p	PAR-CLIP	23592263
MIRT453935	hsa-miR-365b-3p	PAR-CLIP	23592263
MIRT453934	hsa-miR-5197-3p	PAR-CLIP	23592263
MIRT453933	hsa-miR-5586-3p	PAR-CLIP	23592263
MIRT453932	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT453931	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT453930	hsa-miR-211-3p	PAR-CLIP	23592263
MIRT453928	hsa-miR-4270	PAR-CLIP	23592263
MIRT453929	hsa-miR-4441	PAR-CLIP	23592263
MIRT453927	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT453926	hsa-miR-298	PAR-CLIP	23592263
MIRT453925	hsa-miR-615-5p	PAR-CLIP	23592263
MIRT453924	hsa-miR-7704	PAR-CLIP	23592263
MIRT453923	hsa-miR-124-3p	PAR-CLIP	23592263
MIRT453922	hsa-miR-506-3p	PAR-CLIP	23592263
MIRT453921	hsa-miR-4477b	PAR-CLIP	23592263
MIRT453920	hsa-miR-7856-5p	PAR-CLIP	23592263
MIRT453923	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT453938	hsa-miR-3714	PAR-CLIP	20371350
MIRT453937	hsa-miR-3910	PAR-CLIP	20371350
MIRT453936	hsa-miR-365a-3p	PAR-CLIP	20371350
MIRT453935	hsa-miR-365b-3p	PAR-CLIP	20371350
MIRT453934	hsa-miR-5197-3p	PAR-CLIP	20371350
MIRT453933	hsa-miR-5586-3p	PAR-CLIP	20371350
MIRT453932	hsa-miR-1910-3p	PAR-CLIP	20371350
MIRT453931	hsa-miR-6511a-5p	PAR-CLIP	20371350
MIRT453930	hsa-miR-211-3p	PAR-CLIP	20371350
MIRT453928	hsa-miR-4270	PAR-CLIP	20371350
MIRT453929	hsa-miR-4441	PAR-CLIP	20371350
MIRT453927	hsa-miR-6754-5p	PAR-CLIP	20371350
MIRT453926	hsa-miR-298	PAR-CLIP	20371350
MIRT453923	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT453922	hsa-miR-506-3p	PAR-CLIP	20371350
MIRT453921	hsa-miR-4477b	PAR-CLIP	20371350
MIRT453920	hsa-miR-7856-5p	PAR-CLIP	20371350
MIRT453923	hsa-miR-124-3p	PAR-CLIP	23592263
MIRT453938	hsa-miR-3714	PAR-CLIP	23592263
MIRT453937	hsa-miR-3910	PAR-CLIP	23592263
MIRT453936	hsa-miR-365a-3p	PAR-CLIP	23592263
MIRT453935	hsa-miR-365b-3p	PAR-CLIP	23592263
MIRT453934	hsa-miR-5197-3p	PAR-CLIP	23592263
MIRT453933	hsa-miR-5586-3p	PAR-CLIP	23592263
MIRT453932	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT453931	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT453930	hsa-miR-211-3p	PAR-CLIP	23592263
MIRT453928	hsa-miR-4270	PAR-CLIP	23592263
MIRT453929	hsa-miR-4441	PAR-CLIP	23592263
MIRT453927	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT453926	hsa-miR-298	PAR-CLIP	23592263
MIRT453925	hsa-miR-615-5p	PAR-CLIP	23592263
MIRT453924	hsa-miR-7704	PAR-CLIP	23592263
MIRT453923	hsa-miR-124-3p	PAR-CLIP	23592263
MIRT453922	hsa-miR-506-3p	PAR-CLIP	23592263
MIRT453921	hsa-miR-4477b	PAR-CLIP	23592263
MIRT453920	hsa-miR-7856-5p	PAR-CLIP	23592263
MIRT903511	hsa-miR-3675-5p	CLIP-seq
MIRT903512	hsa-miR-3929	CLIP-seq
MIRT903513	hsa-miR-4419b	CLIP-seq
MIRT903514	hsa-miR-4478	CLIP-seq
MIRT903515	hsa-miR-4640-5p	CLIP-seq
MIRT903516	hsa-miR-4663	CLIP-seq
MIRT903517	hsa-miR-4726-5p	CLIP-seq
MIRT903518	hsa-miR-4755-3p	CLIP-seq
MIRT903519	hsa-miR-1294	CLIP-seq
MIRT903520	hsa-miR-3179	CLIP-seq
MIRT903521	hsa-miR-3202	CLIP-seq
MIRT903522	hsa-miR-4316	CLIP-seq
MIRT903523	hsa-miR-4455	CLIP-seq
MIRT903524	hsa-miR-4728-5p	CLIP-seq
MIRT903525	hsa-miR-4747-5p	CLIP-seq
MIRT903526	hsa-miR-4775	CLIP-seq
MIRT903527	hsa-miR-590-3p	CLIP-seq
MIRT1967878	hsa-miR-125a-3p	CLIP-seq
MIRT1967879	hsa-miR-1266	CLIP-seq
MIRT1967880	hsa-miR-29a	CLIP-seq
MIRT1967881	hsa-miR-29b	CLIP-seq
MIRT1967882	hsa-miR-29c	CLIP-seq
MIRT1967883	hsa-miR-3065-3p	CLIP-seq
MIRT1967884	hsa-miR-338-3p	CLIP-seq
MIRT1967885	hsa-miR-3664-3p	CLIP-seq
MIRT1967886	hsa-miR-3934	CLIP-seq
MIRT1967887	hsa-miR-4427	CLIP-seq
MIRT1967888	hsa-miR-4518	CLIP-seq
MIRT1967889	hsa-miR-4530	CLIP-seq
MIRT1967890	hsa-miR-4680-3p	CLIP-seq
MIRT1967891	hsa-miR-4701-5p	CLIP-seq
MIRT1967892	hsa-miR-4717-3p	CLIP-seq
MIRT1967893	hsa-miR-4790-3p	CLIP-seq
MIRT1967894	hsa-miR-550a	CLIP-seq
MIRT1967895	hsa-miR-588	CLIP-seq
MIRT1967896	hsa-miR-764	CLIP-seq
MIRT1967897	hsa-miR-767-5p	CLIP-seq
MIRT2386362	hsa-miR-3176	CLIP-seq
MIRT1967884	hsa-miR-338-3p	CLIP-seq
MIRT2386363	hsa-miR-3922-3p	CLIP-seq
MIRT1967889	hsa-miR-4530	CLIP-seq
MIRT1967891	hsa-miR-4701-5p	CLIP-seq
MIRT1967892	hsa-miR-4717-3p	CLIP-seq
MIRT2386364	hsa-miR-4757-5p	CLIP-seq
MIRT1967895	hsa-miR-588	CLIP-seq

Gene ontology (GO) Show/Hide all (6)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	15799966, 21778237, 23563313, 25355947, 26496610, 28514442, 32296183, 33961781, 35271311, 37172566
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA

Other IDs

• MIM: 608216
• HGNC: 17902
• e!Ensembl: ENSG00000170619

Protein

• UniProt ID: Q9GZQ3
• Protein name: COMM domain-containing protein 5 (Hypertension-related calcium-regulated gene protein) (HCaRG)
• Protein function: Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). May modulate ac
• PDB: 8ESD , 8F2R , 8F2U , 8P0W
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07258	COMM_domain	149 → 216	COMM domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in heart, stomach, jejunum, kidney, liver, and adrenal gland. Expression was generally higher in adult organs than in fetal tissues, particularly in heart, kidney, and liver. {ECO:0000269|PubMed:10918053, ECO:0000269|P
• Sequence:

  MSAVGAATPYLHHPGDSHSGRVSFLGAQLPPEVAAMARLLGDLDRSTFRKLLKFVVSSLQ
  GEDCREAVQRLGVSANLPEEQLGALLAGMHTLLQQALRLPPTSLKPDTFRDQLQELCIPQ
  DLVGDLASVVFGSQRPLLDSVAQQQGAWLPHVADFRWRVDVAISTSALARSLQPSVLMQL
  KLSDGSAYRFEVPTAKFQELRYSVALVLKEMADLEKRCERRLQD

• Sequence length: 224

Pathways

Reactome Pathway:

Neddylation

Related Genes

No strongly related genes found yet for COMMD5.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to COMMD5.