COMMD3 (COMM domain containing 3)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 23412
• Gene name: COMM domain containing 3
• Gene symbol: COMMD3
• Synonyms (NCBI Gene): BUP, C10orf8
• Chromosome: 10
• Chromosome location: 10p12.2

miRNA Show/Hide all (92)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029328	hsa-miR-26b-5p	Microarray	19088304
MIRT056055	hsa-miR-10a-3p	PAR-CLIP	20371350
MIRT056057	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT504104	hsa-miR-627-3p	PAR-CLIP	20371350
MIRT056055	hsa-miR-10a-3p	PAR-CLIP	20371350
MIRT056057	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT504104	hsa-miR-627-3p	PAR-CLIP	20371350
MIRT056055	hsa-miR-10a-3p	PAR-CLIP	21572407
MIRT056057	hsa-miR-651-3p	PAR-CLIP	21572407
MIRT504104	hsa-miR-627-3p	PAR-CLIP	21572407
MIRT056055	hsa-miR-10a-3p	PAR-CLIP	23446348
MIRT056057	hsa-miR-651-3p	PAR-CLIP	23446348
MIRT504104	hsa-miR-627-3p	PAR-CLIP	23446348
MIRT056055	hsa-miR-10a-3p	PAR-CLIP	20371350
MIRT056057	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT504104	hsa-miR-627-3p	PAR-CLIP	20371350
MIRT056055	hsa-miR-10a-3p	PAR-CLIP	20371350
MIRT056057	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT504104	hsa-miR-627-3p	PAR-CLIP	20371350
MIRT056055	hsa-miR-10a-3p	PAR-CLIP	21572407
MIRT056057	hsa-miR-651-3p	PAR-CLIP	21572407
MIRT504104	hsa-miR-627-3p	PAR-CLIP	21572407
MIRT056055	hsa-miR-10a-3p	PAR-CLIP	23446348
MIRT056057	hsa-miR-651-3p	PAR-CLIP	23446348
MIRT504104	hsa-miR-627-3p	PAR-CLIP	23446348
MIRT903408	hsa-miR-106a	CLIP-seq
MIRT903409	hsa-miR-106b	CLIP-seq
MIRT903410	hsa-miR-1207-3p	CLIP-seq
MIRT903411	hsa-miR-17	CLIP-seq
MIRT903412	hsa-miR-20a	CLIP-seq
MIRT903413	hsa-miR-20b	CLIP-seq
MIRT903414	hsa-miR-3124-3p	CLIP-seq
MIRT903415	hsa-miR-3609	CLIP-seq
MIRT903416	hsa-miR-3671	CLIP-seq
MIRT903417	hsa-miR-377	CLIP-seq
MIRT903418	hsa-miR-4267	CLIP-seq
MIRT903419	hsa-miR-4446-5p	CLIP-seq
MIRT903420	hsa-miR-4493	CLIP-seq
MIRT903421	hsa-miR-4698	CLIP-seq
MIRT903422	hsa-miR-4708-3p	CLIP-seq
MIRT903423	hsa-miR-4755-5p	CLIP-seq
MIRT903424	hsa-miR-4790-3p	CLIP-seq
MIRT903425	hsa-miR-4796-3p	CLIP-seq
MIRT903426	hsa-miR-519d	CLIP-seq
MIRT903427	hsa-miR-548ah	CLIP-seq
MIRT903428	hsa-miR-553	CLIP-seq
MIRT903429	hsa-miR-635	CLIP-seq
MIRT903430	hsa-miR-642a	CLIP-seq
MIRT903431	hsa-miR-876-3p	CLIP-seq
MIRT903432	hsa-miR-890	CLIP-seq
MIRT903433	hsa-miR-93	CLIP-seq
MIRT1967833	hsa-miR-1238	CLIP-seq
MIRT1967834	hsa-miR-200b	CLIP-seq
MIRT1967835	hsa-miR-200c	CLIP-seq
MIRT1967836	hsa-miR-3130-3p	CLIP-seq
MIRT903418	hsa-miR-4267	CLIP-seq
MIRT1967837	hsa-miR-429	CLIP-seq
MIRT1967838	hsa-miR-4750	CLIP-seq
MIRT1967839	hsa-miR-4793-3p	CLIP-seq
MIRT903414	hsa-miR-3124-3p	CLIP-seq
MIRT903416	hsa-miR-3671	CLIP-seq
MIRT903417	hsa-miR-377	CLIP-seq
MIRT903418	hsa-miR-4267	CLIP-seq
MIRT903419	hsa-miR-4446-5p	CLIP-seq
MIRT2203739	hsa-miR-4724-5p	CLIP-seq
MIRT903423	hsa-miR-4755-5p	CLIP-seq
MIRT903428	hsa-miR-553	CLIP-seq
MIRT2203740	hsa-miR-607	CLIP-seq
MIRT903429	hsa-miR-635	CLIP-seq
MIRT903430	hsa-miR-642a	CLIP-seq
MIRT903432	hsa-miR-890	CLIP-seq
MIRT2203741	hsa-miR-935	CLIP-seq
MIRT903410	hsa-miR-1207-3p	CLIP-seq
MIRT1967833	hsa-miR-1238	CLIP-seq
MIRT1967836	hsa-miR-3130-3p	CLIP-seq
MIRT903418	hsa-miR-4267	CLIP-seq
MIRT903420	hsa-miR-4493	CLIP-seq
MIRT903422	hsa-miR-4708-3p	CLIP-seq
MIRT1967838	hsa-miR-4750	CLIP-seq
MIRT1967839	hsa-miR-4793-3p	CLIP-seq
MIRT903428	hsa-miR-553	CLIP-seq
MIRT903431	hsa-miR-876-3p	CLIP-seq
MIRT903410	hsa-miR-1207-3p	CLIP-seq
MIRT1967833	hsa-miR-1238	CLIP-seq
MIRT1967836	hsa-miR-3130-3p	CLIP-seq
MIRT903418	hsa-miR-4267	CLIP-seq
MIRT903420	hsa-miR-4493	CLIP-seq
MIRT903422	hsa-miR-4708-3p	CLIP-seq
MIRT1967838	hsa-miR-4750	CLIP-seq
MIRT1967839	hsa-miR-4793-3p	CLIP-seq
MIRT903428	hsa-miR-553	CLIP-seq
MIRT903431	hsa-miR-876-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (7)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	15799966, 21778237, 21900206, 23563313, 25355947, 26496610, 28514442, 30833792, 32296183, 33961781, 37172566
GO:0005576	Component	Extracellular region	TAS
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006814	Process	Sodium ion transport	IEA
GO:1904813	Component	Ficolin-1-rich granule lumen	TAS

Other IDs

• MIM: 616700
• HGNC: 23332
• e!Ensembl: ENSG00000148444

Protein

• UniProt ID: Q9UBI1
• Protein name: COMM domain-containing protein 3 (Protein Bup) (Protein PIL)
• Protein function: Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). May modulate ac
• PDB: 8F2R , 8F2U , 8P0W
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07258	COMM_domain	122 → 194	COMM domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed with highest expression in thymus. {ECO:0000269|PubMed:15799966}.
• Sequence:

  MELSESVQKGFQMLADPRSFDSNAFTLLLRAAFQSLLDAQADEAVLDHPDLKHIDPVVLK
  HCHAAAATYILEAGKHRADKSTLSTYLEDCKFDRERIELFCTEYQNNKNSLEILLGSIGR
  SLPHITDVSWRLEYQIKTNQLHRMYRPAYLVTLSVQNTDSPSYPEISFSCSMEQLQDLVG
  KLKDASKSLERATQL

• Sequence length: 195

Pathways

Reactome Pathway

Neutrophil degranulation

Neddylation

Related Genes

No strongly related genes found yet for COMMD3.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to COMMD3.