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Gene Gene information from NCBI Gene database.
Entrez ID 51122
Gene name COMM domain containing 2
Gene symbol COMMD2
Synonyms (NCBI Gene)
HSPC042
Chromosome 3
Chromosome location 3q25.1
miRNA miRNA information provided by mirtarbase database.
706 Show/Hide all (706)
miRTarBase ID miRNA Experiments Reference
MIRT023685 hsa-miR-1-3p Proteomics;Microarray 18668037
MIRT039863 hsa-miR-615-3p CLASH 23622248
MIRT624299 hsa-miR-4714-5p HITS-CLIP 23824327
MIRT624298 hsa-miR-660-3p HITS-CLIP 23824327
MIRT624297 hsa-miR-4324 HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
2
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 15799966, 21778237, 23563313, 25355947, 26496610, 28514442, 28892079, 30833792, 32296183, 32814053, 33961781, 35271311, 37172566
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
616699 24993 ENSG00000114744
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q86X83
Protein name COMM domain-containing protein 2
Protein function Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). May modulate ac
PDB 8F2R , 8F2U , 8P0W
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07258 COMM_domain 121 → 191 COMM domain Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:15799966}.
Sequence
MLLELSEEHKEHLAFLPQVDSAVVAEFGRIAVEFLRRGANPKIYEGAARKLNVSSDTVQH
GVEGLTYLLTESSKLMISELDFQDSVFVLGFSEELNKLLLQLYLDNRKEIRTILSELAPS
LPSYHNLEWRLDVQLASRSLRQQIKPAVTIKLHLNQNGDHNTKVLQTDPATLLHLVQQLE
QALEEMKTNHC
RRVVRNIK
Sequence length 199
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Neddylation