CNN1 (calponin 1)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 1264
• Gene name: Calponin 1
• Gene symbol: CNN1
• Synonyms (NCBI Gene): HEL-S-14, SMCC, Sm-Calp
• Chromosome: 19
• Chromosome location: 19p13.2

miRNA Show/Hide all (14)

miRTarBase ID	miRNA	Experiments	Reference
MIRT736343	hsa-miR-106b-5p	Luciferase reporter assay, qRT-PCR	31986487
MIRT899785	hsa-miR-1825	CLIP-seq
MIRT899786	hsa-miR-199a-5p	CLIP-seq
MIRT899787	hsa-miR-199b-5p	CLIP-seq
MIRT899788	hsa-miR-218	CLIP-seq
MIRT899789	hsa-miR-2861	CLIP-seq
MIRT899790	hsa-miR-3064-5p	CLIP-seq
MIRT899791	hsa-miR-3652	CLIP-seq
MIRT899792	hsa-miR-3925-3p	CLIP-seq
MIRT899793	hsa-miR-4430	CLIP-seq
MIRT899794	hsa-miR-4505	CLIP-seq
MIRT899795	hsa-miR-4729	CLIP-seq
MIRT1966896	hsa-miR-637	CLIP-seq
MIRT1966896	hsa-miR-637	CLIP-seq

Gene ontology (GO) Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IEA
GO:0005515	Function	Protein binding	IPI	27107012, 28514442, 33961781
GO:0005516	Function	Calmodulin binding	IEA
GO:0005856	Component	Cytoskeleton	IDA	8616889
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006940	Process	Regulation of smooth muscle contraction	TAS	14550641
GO:0007015	Process	Actin filament organization	IBA
GO:0015629	Component	Actin cytoskeleton	IBA
GO:0031032	Process	Actomyosin structure organization	IEA
GO:0051015	Function	Actin filament binding	IBA
GO:1904706	Process	Negative regulation of vascular associated smooth muscle cell proliferation	IGI	26315405

Other IDs

• MIM: 600806
• HGNC: 2155
• e!Ensembl: ENSG00000130176

Protein

• UniProt ID: P51911
• Protein name: Calponin-1 (Basic calponin) (Calponin H1, smooth muscle)
• Protein function: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-A
• PDB: 1WYP
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00307	CH	28 → 133	Calponin homology (CH) domain	Domain
  PF00402	Calponin	164 → 188	Calponin family repeat	Repeat
  PF00402	Calponin	204 → 228	Calponin family repeat	Repeat
  PF00402	Calponin	243 → 267	Calponin family repeat	Repeat

• Tissue specificity: TISSUE SPECIFICITY: Smooth muscle, and tissues containing significant amounts of smooth muscle.
• Sequence:

  MSSAHFNRGPAYGLSAEVKNKLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIIL
  CEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQV
  QSTLLALASMAKTKGNKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKFASQQGMT
  AYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDT
  LNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTPEYPELGEPAHNHHAHNYYNSA

• Sequence length: 297

Related Genes

No strongly related genes found yet for CNN1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to CNN1.