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Gene Gene information from NCBI Gene database.
Entrez ID 54918
Gene name CKLF like MARVEL transmembrane domain containing 6
Gene symbol CMTM6
Synonyms (NCBI Gene)
CKLFSF6PRO2219
Chromosome 3
Chromosome location 3p22.3
Summary This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is
miRNA miRNA information provided by mirtarbase database.
479 Show/Hide all (479)
miRTarBase ID miRNA Experiments Reference
MIRT019660 hsa-miR-378a-3p Sequencing 20371350
MIRT021869 hsa-miR-128-3p Microarray 17612493
MIRT024261 hsa-miR-215-5p Microarray 19074876
MIRT026194 hsa-miR-192-5p Microarray 19074876
MIRT029005 hsa-miR-26b-5p Microarray 19088304
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17 Show/Hide all (17)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 28813410, 28813417, 32296183, 33961781
GO:0005768 Component Endosome IEA
GO:0005886 Component Plasma membrane IDA 28813410, 28813417
GO:0005886 Component Plasma membrane IEA
GO:0005886 Component Plasma membrane TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607889 19177 ENSG00000091317
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NX76
Protein name CKLF-like MARVEL transmembrane domain-containing protein 6 (Chemokine-like factor superfamily member 6)
Protein function Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling en
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01284 MARVEL 35 → 154 Membrane-associating domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in the leukocytes, placenta and testis. {ECO:0000269|PubMed:12782130}.
Sequence
Sequence length 183
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Neutrophil degranulation