CMTM6 (CKLF like MARVEL transmembrane domain containing 6)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 54918 |
| Gene name | CKLF like MARVEL transmembrane domain containing 6 |
| Gene symbol | CMTM6 |
| Synonyms (NCBI Gene) |
CKLFSF6PRO2219
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| Chromosome | 3 |
| Chromosome location | 3p22.3 |
| Summary | This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9NX76 | ||||||||||
| Protein name | CKLF-like MARVEL transmembrane domain-containing protein 6 (Chemokine-like factor superfamily member 6) | ||||||||||
| Protein function | Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling en | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expressed in the leukocytes, placenta and testis. {ECO:0000269|PubMed:12782130}. | ||||||||||
| Sequence |
MENGAVYSPTTEEDPGPARGPRSGLAAYFFMGRLPLLRRVLKGLQLLLSLLAFICEEVVS |
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| Sequence length | 183 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Related Genes
Genes most often co-reported with CMTM6 across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to CMTM6 (see Related Genes above), that are NOT already directly curated for CMTM6 itself -- a lead worth checking, not a confirmed association.
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