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Gene Gene information from NCBI Gene database.
Entrez ID 146223
Gene name CKLF like MARVEL transmembrane domain containing 4
Gene symbol CMTM4
Synonyms (NCBI Gene)
CKLFSF4
Chromosome 16
Chromosome location 16q21-q22.1
Summary This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on
miRNA miRNA information provided by mirtarbase database.
1321 Show/Hide all (1321)
miRTarBase ID miRNA Experiments Reference
MIRT003843 hsa-miR-373-3p Microarray 15685193
MIRT019833 hsa-miR-375 Microarray 20215506
MIRT003843 hsa-miR-373-3p Microarray 15685193
MIRT021171 hsa-miR-186-5p Sequencing 20371350
MIRT022566 hsa-miR-124-3p Microarray 18668037
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
3
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 28813410, 28813417, 32296183
GO:0016020 Component Membrane IBA
GO:0016020 Component Membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607887 19175 ENSG00000183723
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8IZR5
Protein name CKLF-like MARVEL transmembrane domain-containing protein 4 (Chemokine-like factor superfamily member 4)
Protein function Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for deg
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01284 MARVEL 49 → 170 Membrane-associating domain Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in testis and prostate. {ECO:0000269|PubMed:12782130}.
Sequence
MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVA
QVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNL
TDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFL
AVQKWRVSVR
QQSTNDYIRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA
Sequence length 234
Interactions View interactions