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Gene Gene information from NCBI Gene database.
Entrez ID 134147
Gene name Carboxymethylenebutenolidase homolog
Gene symbol CMBL
Synonyms (NCBI Gene)
JS-1
Chromosome 5
Chromosome location 5p15.2
Summary CMBL (EC 3.1.1.45) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL preferentially cleaves cyclic esters, and it activates medoxomil-ester prodrugs in which the medoxomil moiety is linked to an o
miRNA miRNA information provided by mirtarbase database.
719 Show/Hide all (719)
miRTarBase ID miRNA Experiments Reference
MIRT714594 hsa-miR-1266-3p HITS-CLIP 19536157
MIRT714592 hsa-miR-4695-3p HITS-CLIP 19536157
MIRT714593 hsa-miR-2052 HITS-CLIP 19536157
MIRT714591 hsa-miR-19a-5p HITS-CLIP 19536157
MIRT714590 hsa-miR-19b-1-5p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
7 Show/Hide all (7)
GO ID Ontology Definition Evidence Reference
GO:0005737 Component Cytoplasm IEA
GO:0005829 Component Cytosol IEA
GO:0005829 Component Cytosol TAS
GO:0006805 Process Xenobiotic metabolic process TAS
GO:0016787 Function Hydrolase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
613379 25090 ENSG00000164237
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96DG6
Protein name Carboxymethylenebutenolidase homolog (EC 3.1.-.-)
Protein function Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01738 DLH 30 → 245 Dienelactone hydrolase family Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed, with highest levels in liver, followed by kidney, small intestine and colon. Present in liver and intestine (at protein level). {ECO:0000269|PubMed:20177059}.
Sequence
Sequence length 245
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Metabolic pathways Phase I - Functionalization of compounds