CLK4 (CDC like kinase 4)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 57396
• Gene name: CDC like kinase 4
• Gene symbol: CLK4
• Synonyms (NCBI Gene): -
• Chromosome: 5
• Chromosome location: 5q35.3
• Summary: The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of splic

miRNA Show/Hide all (192)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024782	hsa-miR-215-5p	Microarray	19074876
MIRT026138	hsa-miR-192-5p	Microarray	19074876
MIRT631793	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT631792	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT631791	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT631790	hsa-miR-5693	HITS-CLIP	23824327
MIRT675225	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT631789	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT631788	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT631787	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT675224	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT675223	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT631786	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT631785	hsa-miR-891a-3p	HITS-CLIP	23824327
MIRT631784	hsa-miR-5698	HITS-CLIP	23824327
MIRT631793	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT631792	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT631791	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT631790	hsa-miR-5693	HITS-CLIP	23824327
MIRT631789	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT631788	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT631787	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT631786	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT631785	hsa-miR-891a-3p	HITS-CLIP	23824327
MIRT631784	hsa-miR-5698	HITS-CLIP	23824327
MIRT517841	hsa-miR-4438	PAR-CLIP	23446348
MIRT517840	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT517839	hsa-miR-149-5p	PAR-CLIP	23446348
MIRT517838	hsa-miR-6889-3p	PAR-CLIP	23446348
MIRT517837	hsa-miR-4252	PAR-CLIP	23446348
MIRT517836	hsa-miR-1254	PAR-CLIP	23446348
MIRT517835	hsa-miR-3116	PAR-CLIP	23446348
MIRT517834	hsa-miR-661	PAR-CLIP	23446348
MIRT517833	hsa-miR-1271-3p	PAR-CLIP	23446348
MIRT517832	hsa-miR-550a-3-5p	PAR-CLIP	23446348
MIRT517831	hsa-miR-550a-5p	PAR-CLIP	23446348
MIRT517830	hsa-miR-5095	PAR-CLIP	23446348
MIRT517829	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT517828	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT517827	hsa-miR-550b-2-5p	PAR-CLIP	23446348
MIRT631793	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT631792	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT631791	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT631790	hsa-miR-5693	HITS-CLIP	23824327
MIRT675225	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT631789	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT631788	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT631787	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT675224	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT675223	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT631786	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT631785	hsa-miR-891a-3p	HITS-CLIP	23824327
MIRT631784	hsa-miR-5698	HITS-CLIP	23824327
MIRT631793	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT631792	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT631791	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT631790	hsa-miR-5693	HITS-CLIP	23824327
MIRT631789	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT631788	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT631787	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT631786	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT631785	hsa-miR-891a-3p	HITS-CLIP	23824327
MIRT631784	hsa-miR-5698	HITS-CLIP	23824327
MIRT517841	hsa-miR-4438	PAR-CLIP	23446348
MIRT517840	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT517839	hsa-miR-149-5p	PAR-CLIP	23446348
MIRT517838	hsa-miR-6889-3p	PAR-CLIP	23446348
MIRT517837	hsa-miR-4252	PAR-CLIP	23446348
MIRT517836	hsa-miR-1254	PAR-CLIP	23446348
MIRT517835	hsa-miR-3116	PAR-CLIP	23446348
MIRT517834	hsa-miR-661	PAR-CLIP	23446348
MIRT517833	hsa-miR-1271-3p	PAR-CLIP	23446348
MIRT517832	hsa-miR-550a-3-5p	PAR-CLIP	23446348
MIRT517831	hsa-miR-550a-5p	PAR-CLIP	23446348
MIRT517830	hsa-miR-5095	PAR-CLIP	23446348
MIRT517829	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT517828	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT517827	hsa-miR-550b-2-5p	PAR-CLIP	23446348
MIRT896710	hsa-miR-1236	CLIP-seq
MIRT896711	hsa-miR-216a	CLIP-seq
MIRT896712	hsa-miR-216b	CLIP-seq
MIRT896713	hsa-miR-3123	CLIP-seq
MIRT896714	hsa-miR-34b	CLIP-seq
MIRT896715	hsa-miR-3613-3p	CLIP-seq
MIRT896716	hsa-miR-3925-5p	CLIP-seq
MIRT896717	hsa-miR-3978	CLIP-seq
MIRT896718	hsa-miR-4257	CLIP-seq
MIRT896719	hsa-miR-4716-5p	CLIP-seq
MIRT896720	hsa-miR-4777-5p	CLIP-seq
MIRT896721	hsa-miR-518d-5p	CLIP-seq
MIRT896722	hsa-miR-519b-5p	CLIP-seq
MIRT896723	hsa-miR-519c-5p	CLIP-seq
MIRT896724	hsa-miR-520c-5p	CLIP-seq
MIRT896725	hsa-miR-526a	CLIP-seq
MIRT896726	hsa-miR-548c-3p	CLIP-seq
MIRT896727	hsa-miR-642b	CLIP-seq
MIRT896728	hsa-miR-890	CLIP-seq
MIRT896710	hsa-miR-1236	CLIP-seq
MIRT896711	hsa-miR-216a	CLIP-seq
MIRT896712	hsa-miR-216b	CLIP-seq
MIRT1965876	hsa-miR-31	CLIP-seq
MIRT896713	hsa-miR-3123	CLIP-seq
MIRT896716	hsa-miR-3925-5p	CLIP-seq
MIRT896719	hsa-miR-4716-5p	CLIP-seq
MIRT896720	hsa-miR-4777-5p	CLIP-seq
MIRT896721	hsa-miR-518d-5p	CLIP-seq
MIRT896722	hsa-miR-519b-5p	CLIP-seq
MIRT896723	hsa-miR-519c-5p	CLIP-seq
MIRT896724	hsa-miR-520c-5p	CLIP-seq
MIRT896725	hsa-miR-526a	CLIP-seq
MIRT1965877	hsa-miR-548an	CLIP-seq
MIRT896727	hsa-miR-642b	CLIP-seq
MIRT896710	hsa-miR-1236	CLIP-seq
MIRT896711	hsa-miR-216a	CLIP-seq
MIRT896712	hsa-miR-216b	CLIP-seq
MIRT896713	hsa-miR-3123	CLIP-seq
MIRT896716	hsa-miR-3925-5p	CLIP-seq
MIRT896720	hsa-miR-4777-5p	CLIP-seq
MIRT896721	hsa-miR-518d-5p	CLIP-seq
MIRT896722	hsa-miR-519b-5p	CLIP-seq
MIRT896723	hsa-miR-519c-5p	CLIP-seq
MIRT896724	hsa-miR-520c-5p	CLIP-seq
MIRT896725	hsa-miR-526a	CLIP-seq
MIRT896727	hsa-miR-642b	CLIP-seq
MIRT896710	hsa-miR-1236	CLIP-seq
MIRT896711	hsa-miR-216a	CLIP-seq
MIRT896712	hsa-miR-216b	CLIP-seq
MIRT896713	hsa-miR-3123	CLIP-seq
MIRT896716	hsa-miR-3925-5p	CLIP-seq
MIRT896720	hsa-miR-4777-5p	CLIP-seq
MIRT896721	hsa-miR-518d-5p	CLIP-seq
MIRT896722	hsa-miR-519b-5p	CLIP-seq
MIRT896723	hsa-miR-519c-5p	CLIP-seq
MIRT896724	hsa-miR-520c-5p	CLIP-seq
MIRT896725	hsa-miR-526a	CLIP-seq
MIRT896727	hsa-miR-642b	CLIP-seq
MIRT2447195	hsa-miR-134	CLIP-seq
MIRT2447196	hsa-miR-3118	CLIP-seq
MIRT2447197	hsa-miR-3164	CLIP-seq
MIRT2447198	hsa-miR-4677-3p	CLIP-seq
MIRT2447199	hsa-miR-4679	CLIP-seq
MIRT2447195	hsa-miR-134	CLIP-seq
MIRT2447196	hsa-miR-3118	CLIP-seq
MIRT2447197	hsa-miR-3164	CLIP-seq
MIRT2447198	hsa-miR-4677-3p	CLIP-seq
MIRT2447199	hsa-miR-4679	CLIP-seq
MIRT2504793	hsa-miR-1231	CLIP-seq
MIRT2504794	hsa-miR-132	CLIP-seq
MIRT2447195	hsa-miR-134	CLIP-seq
MIRT2504795	hsa-miR-186	CLIP-seq
MIRT2504796	hsa-miR-212	CLIP-seq
MIRT2504797	hsa-miR-217	CLIP-seq
MIRT2504798	hsa-miR-30a	CLIP-seq
MIRT2504799	hsa-miR-30b	CLIP-seq
MIRT2504800	hsa-miR-30c	CLIP-seq
MIRT2504801	hsa-miR-30d	CLIP-seq
MIRT2504802	hsa-miR-30e	CLIP-seq
MIRT2447196	hsa-miR-3118	CLIP-seq
MIRT2447197	hsa-miR-3164	CLIP-seq
MIRT2504803	hsa-miR-3620	CLIP-seq
MIRT2504804	hsa-miR-3913-3p	CLIP-seq
MIRT2504805	hsa-miR-4282	CLIP-seq
MIRT2504806	hsa-miR-4303	CLIP-seq
MIRT2447198	hsa-miR-4677-3p	CLIP-seq
MIRT2447199	hsa-miR-4679	CLIP-seq
MIRT2504807	hsa-miR-4682	CLIP-seq
MIRT2504808	hsa-miR-4732-3p	CLIP-seq
MIRT2504809	hsa-miR-4762-3p	CLIP-seq
MIRT2504810	hsa-miR-489	CLIP-seq
MIRT2504811	hsa-miR-499-3p	CLIP-seq
MIRT2504812	hsa-miR-499a-3p	CLIP-seq
MIRT896721	hsa-miR-518d-5p	CLIP-seq
MIRT896722	hsa-miR-519b-5p	CLIP-seq
MIRT896723	hsa-miR-519c-5p	CLIP-seq
MIRT896724	hsa-miR-520c-5p	CLIP-seq
MIRT896725	hsa-miR-526a	CLIP-seq
MIRT2504813	hsa-miR-532-5p	CLIP-seq
MIRT2504814	hsa-miR-587	CLIP-seq
MIRT2504815	hsa-miR-633	CLIP-seq
MIRT2504816	hsa-miR-654-3p	CLIP-seq
MIRT2504817	hsa-miR-659	CLIP-seq
MIRT2504793	hsa-miR-1231	CLIP-seq
MIRT2504797	hsa-miR-217	CLIP-seq
MIRT2504803	hsa-miR-3620	CLIP-seq
MIRT2504804	hsa-miR-3913-3p	CLIP-seq
MIRT2504808	hsa-miR-4732-3p	CLIP-seq
MIRT2504810	hsa-miR-489	CLIP-seq
MIRT2504811	hsa-miR-499-3p	CLIP-seq
MIRT2504812	hsa-miR-499a-3p	CLIP-seq
MIRT2504813	hsa-miR-532-5p	CLIP-seq
MIRT2504814	hsa-miR-587	CLIP-seq
MIRT2504816	hsa-miR-654-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	ISS
GO:0004712	Function	Protein serine/threonine/tyrosine kinase activity	IEA
GO:0004713	Function	Protein tyrosine kinase activity	IBA
GO:0004713	Function	Protein tyrosine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0043484	Process	Regulation of RNA splicing	IBA
GO:0043484	Process	Regulation of RNA splicing	IEA
GO:0043484	Process	Regulation of RNA splicing	IMP	19168442
GO:0106310	Function	Protein serine kinase activity	IEA

Other IDs

• MIM: 607969
• HGNC: 13659
• e!Ensembl: ENSG00000113240

Protein

• UniProt ID: Q9HAZ1
• Protein name: Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4)
• Protein function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that en
• PDB: 6FYV
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	159 → 475	Protein kinase domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in liver, kidney, heart, muscle, brain and endothelial cells. {ECO:0000269|PubMed:11170754, ECO:0000269|PubMed:19168442}.
• Sequence:

  MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEAR
  SLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRH
  CSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHG
  MDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFE
  LLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYV
  VKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDV
  WSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEH
  SSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKK
  K

• Sequence length: 481

Pathways

KEGG Pathway:

Legionellosis

Related Genes

No strongly related genes found yet for CLK4.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to CLK4.