CLIP3 (CAP-Gly domain containing linker protein 3)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 25999
• Gene name: CAP-Gly domain containing linker protein 3
• Gene symbol: CLIP3
• Synonyms (NCBI Gene): CLIPR-59, CLIPR59, RSNL1
• Chromosome: 19
• Chromosome location: 19q13.12
• Summary: This gene encodes a member of the cytoplasmic linker protein 170 family. Members of this protein family contain a cytoskeleton-associated protein glycine-rich domain and mediate the interaction of microtubules with cellular organelles. The encoded protein

miRNA Show/Hide all (96)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018271	hsa-miR-335-5p	Microarray	18185580
MIRT896594	hsa-miR-124	CLIP-seq
MIRT896595	hsa-miR-1275	CLIP-seq
MIRT896596	hsa-miR-1290	CLIP-seq
MIRT896597	hsa-miR-1305	CLIP-seq
MIRT896598	hsa-miR-145	CLIP-seq
MIRT896599	hsa-miR-2467-3p	CLIP-seq
MIRT896600	hsa-miR-300	CLIP-seq
MIRT896601	hsa-miR-3122	CLIP-seq
MIRT896602	hsa-miR-3167	CLIP-seq
MIRT896603	hsa-miR-3180-5p	CLIP-seq
MIRT896604	hsa-miR-3671	CLIP-seq
MIRT896605	hsa-miR-3678-3p	CLIP-seq
MIRT896606	hsa-miR-381	CLIP-seq
MIRT896607	hsa-miR-3913-5p	CLIP-seq
MIRT896608	hsa-miR-3925-3p	CLIP-seq
MIRT896609	hsa-miR-4260	CLIP-seq
MIRT896610	hsa-miR-4476	CLIP-seq
MIRT896611	hsa-miR-450b-3p	CLIP-seq
MIRT896612	hsa-miR-4665-5p	CLIP-seq
MIRT896613	hsa-miR-4685-5p	CLIP-seq
MIRT896614	hsa-miR-485-3p	CLIP-seq
MIRT896615	hsa-miR-506	CLIP-seq
MIRT896616	hsa-miR-526b	CLIP-seq
MIRT896617	hsa-miR-578	CLIP-seq
MIRT896618	hsa-miR-607	CLIP-seq
MIRT896619	hsa-miR-624	CLIP-seq
MIRT896620	hsa-miR-637	CLIP-seq
MIRT896621	hsa-miR-7	CLIP-seq
MIRT896622	hsa-miR-766	CLIP-seq
MIRT896623	hsa-miR-769-3p	CLIP-seq
MIRT896624	hsa-miR-876-5p	CLIP-seq
MIRT2201749	hsa-miR-2110	CLIP-seq
MIRT2201750	hsa-miR-3144-5p	CLIP-seq
MIRT2201751	hsa-miR-3150a-3p	CLIP-seq
MIRT2201752	hsa-miR-3158-3p	CLIP-seq
MIRT2201753	hsa-miR-3191	CLIP-seq
MIRT896609	hsa-miR-4260	CLIP-seq
MIRT2201754	hsa-miR-4652-5p	CLIP-seq
MIRT2201755	hsa-miR-615-5p	CLIP-seq
MIRT2386178	hsa-miR-3120-5p	CLIP-seq
MIRT2201750	hsa-miR-3144-5p	CLIP-seq
MIRT2386179	hsa-miR-3146	CLIP-seq
MIRT2201753	hsa-miR-3191	CLIP-seq
MIRT2386180	hsa-miR-3664-5p	CLIP-seq
MIRT2386181	hsa-miR-4522	CLIP-seq
MIRT2201754	hsa-miR-4652-5p	CLIP-seq
MIRT2386182	hsa-miR-4708-5p	CLIP-seq
MIRT2386183	hsa-miR-4727-3p	CLIP-seq
MIRT2386184	hsa-miR-4768-3p	CLIP-seq
MIRT2386185	hsa-miR-491-5p	CLIP-seq
MIRT2504684	hsa-miR-1266	CLIP-seq
MIRT2504685	hsa-miR-1273f	CLIP-seq
MIRT2504686	hsa-miR-1277	CLIP-seq
MIRT2504687	hsa-miR-1303	CLIP-seq
MIRT2504688	hsa-miR-203	CLIP-seq
MIRT2504689	hsa-miR-3127-5p	CLIP-seq
MIRT2504690	hsa-miR-3159	CLIP-seq
MIRT2504691	hsa-miR-3170	CLIP-seq
MIRT2504692	hsa-miR-3188	CLIP-seq
MIRT2504693	hsa-miR-3189-3p	CLIP-seq
MIRT2504694	hsa-miR-3612	CLIP-seq
MIRT2504695	hsa-miR-3918	CLIP-seq
MIRT896609	hsa-miR-4260	CLIP-seq
MIRT2504696	hsa-miR-4297	CLIP-seq
MIRT2504697	hsa-miR-4443	CLIP-seq
MIRT2504698	hsa-miR-4512	CLIP-seq
MIRT2504699	hsa-miR-4518	CLIP-seq
MIRT2504700	hsa-miR-4534	CLIP-seq
MIRT2504701	hsa-miR-4729	CLIP-seq
MIRT2504702	hsa-miR-4802-5p	CLIP-seq
MIRT2504703	hsa-miR-650	CLIP-seq
MIRT2504704	hsa-miR-651	CLIP-seq
MIRT2504705	hsa-miR-665	CLIP-seq
MIRT2504684	hsa-miR-1266	CLIP-seq
MIRT2504685	hsa-miR-1273f	CLIP-seq
MIRT2504686	hsa-miR-1277	CLIP-seq
MIRT2504688	hsa-miR-203	CLIP-seq
MIRT2504689	hsa-miR-3127-5p	CLIP-seq
MIRT2504690	hsa-miR-3159	CLIP-seq
MIRT2504691	hsa-miR-3170	CLIP-seq
MIRT2504692	hsa-miR-3188	CLIP-seq
MIRT2504693	hsa-miR-3189-3p	CLIP-seq
MIRT2504694	hsa-miR-3612	CLIP-seq
MIRT2504695	hsa-miR-3918	CLIP-seq
MIRT896609	hsa-miR-4260	CLIP-seq
MIRT2504696	hsa-miR-4297	CLIP-seq
MIRT2504697	hsa-miR-4443	CLIP-seq
MIRT2504698	hsa-miR-4512	CLIP-seq
MIRT2504699	hsa-miR-4518	CLIP-seq
MIRT2504700	hsa-miR-4534	CLIP-seq
MIRT2504701	hsa-miR-4729	CLIP-seq
MIRT2504702	hsa-miR-4802-5p	CLIP-seq
MIRT2504703	hsa-miR-650	CLIP-seq
MIRT2504704	hsa-miR-651	CLIP-seq
MIRT2504705	hsa-miR-665	CLIP-seq

Gene ontology (GO) Show/Hide all (37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001934	Process	Positive regulation of protein phosphorylation	ISS
GO:0005515	Function	Protein binding	IPI	26198635, 32296183, 32814053
GO:0005634	Component	Nucleus	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005795	Component	Golgi stack	IEA
GO:0005802	Component	Trans-Golgi network	IEA
GO:0005802	Component	Trans-Golgi network	ISS
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	19139280
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	IMP	15262990
GO:0005938	Component	Cell cortex	IBA
GO:0008017	Function	Microtubule binding	IDA	15262990
GO:0008017	Function	Microtubule binding	IMP	20052288
GO:0010828	Process	Positive regulation of D-glucose transmembrane transport	IEA
GO:0010828	Process	Positive regulation of D-glucose transmembrane transport	ISS
GO:0016020	Component	Membrane	IEA
GO:0018230	Process	Peptidyl-L-cysteine S-palmitoylation	IMP	15262990
GO:0031115	Process	Negative regulation of microtubule polymerization	IMP	15262990
GO:0031122	Process	Cytoplasmic microtubule organization	IBA
GO:0031901	Component	Early endosome membrane	IDA	11854307
GO:0032588	Component	Trans-Golgi network membrane	IDA	11854307
GO:0032588	Component	Trans-Golgi network membrane	IMP	15262990
GO:0035371	Component	Microtubule plus-end	IBA
GO:0035594	Function	Ganglioside binding	IDA	20052288
GO:0043065	Process	Positive regulation of apoptotic process	IMP	20052288
GO:0044091	Process	Membrane biogenesis	IMP	11854307
GO:0045121	Component	Membrane raft	IDA	15262990
GO:0045444	Process	Fat cell differentiation	IEA
GO:0045444	Process	Fat cell differentiation	ISS
GO:0045807	Process	Positive regulation of endocytosis	IMP	11854307
GO:0051010	Function	Microtubule plus-end binding	IBA
GO:0055038	Component	Recycling endosome membrane	IDA	11854307
GO:0098840	Process	Protein transport along microtubule	IMP	20052288
GO:1903078	Process	Positive regulation of protein localization to plasma membrane	IEA
GO:1903078	Process	Positive regulation of protein localization to plasma membrane	ISS

Other IDs

• MIM: 607382
• HGNC: 24314
• e!Ensembl: ENSG00000105270

Protein

• UniProt ID: Q96DZ5
• Protein name: CAP-Gly domain-containing linker protein 3 (Cytoplasmic linker protein 170-related 59 kDa protein) (CLIP-170-related 59 kDa protein) (CLIPR-59)
• Protein function: Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocyt
• PDB: 2CP0
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01302	CAP_GLY	418 → 482	CAP-Gly domain	Domain
  PF01302	CAP_GLY	296 → 360	CAP-Gly domain	Domain
  PF12796	Ank_2	135 → 228	Ankyrin repeats (3 copies)	Repeat

• Sequence:

  MTKTDPAPMAPPPRGEEEEEEEEDEPVPEAPSPTQERRQKPVVHPSAPAPLPKDYAFTFF
  DPNDPACQEILFDPQTTIPELFAIVRQWVPQVQHKIDVIGNEILRRGCHVNDRDGLTDMT
  LLHYACKAGAHGVGDPAAAVRLSQQLLALGADVTLRSRWTNMNALHYAAYFDVPDLVRVL
  LKGARPRVVNSTCSDFNHGSALHIAASSLCLGAAKCLLEHGANPALRNRKGQVPAEVVPD
  PMDMSLDKAEAALVAKELRTLLEEAVPLSCALPKVTLPNYDNVPGNLMLSALGLRLGDRV
  LLDGQKTGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVGGVRYFICPPKQGLFASVSKI
  SKAVDAPPSSVTSTPRTPRMDFSRVTGKGRREHKGKKKTPSSPSLGSLQQRDGAKAEVGD
  QVLVAGQKQGIVRFYGKTDFAPGYWYGIELDQPTGKHDGSVFGVRYFTCPPRHGVFAPAS
  RIQRIGGSTDSPGDSVGAKKVHQVTMTQPKRTFTTVRTPKDIASENSISRLLFCCWFPWM
  LRAEMQS

• Sequence length: 547

Pathways

Reactome Pathway:

Regulation of TNFR1 signaling

Related Genes

No strongly related genes found yet for CLIP3.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to CLIP3.