CLEC12B (C-type lectin domain family 12 member B)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 387837
• Gene name: C-type lectin domain family 12 member B
• Gene symbol: CLEC12B
• Synonyms (NCBI Gene): UNQ5782
• Chromosome: 12
• Chromosome location: 12p13.2

miRNA Show/Hide all (167)

miRTarBase ID	miRNA	Experiments	Reference
MIRT709331	hsa-miR-3133	HITS-CLIP	19536157
MIRT709330	hsa-miR-186-5p	HITS-CLIP	19536157
MIRT527479	hsa-miR-3609	HITS-CLIP	19536157
MIRT527478	hsa-miR-548ah-5p	HITS-CLIP	19536157
MIRT527477	hsa-miR-106a-5p	HITS-CLIP	19536157
MIRT527476	hsa-miR-106b-5p	HITS-CLIP	19536157
MIRT527475	hsa-miR-17-5p	HITS-CLIP	19536157
MIRT527474	hsa-miR-20a-5p	HITS-CLIP	19536157
MIRT527473	hsa-miR-20b-5p	HITS-CLIP	19536157
MIRT527472	hsa-miR-519d-3p	HITS-CLIP	19536157
MIRT527471	hsa-miR-526b-3p	HITS-CLIP	19536157
MIRT527470	hsa-miR-93-5p	HITS-CLIP	19536157
MIRT527469	hsa-miR-4796-3p	HITS-CLIP	19536157
MIRT709329	hsa-miR-577	HITS-CLIP	19536157
MIRT527479	hsa-miR-3609	PAR-CLIP	22012620
MIRT527478	hsa-miR-548ah-5p	PAR-CLIP	22012620
MIRT527477	hsa-miR-106a-5p	PAR-CLIP	22012620
MIRT527476	hsa-miR-106b-5p	PAR-CLIP	22012620
MIRT527475	hsa-miR-17-5p	PAR-CLIP	22012620
MIRT527474	hsa-miR-20a-5p	PAR-CLIP	22012620
MIRT527473	hsa-miR-20b-5p	PAR-CLIP	22012620
MIRT527472	hsa-miR-519d-3p	PAR-CLIP	22012620
MIRT527471	hsa-miR-526b-3p	PAR-CLIP	22012620
MIRT527470	hsa-miR-93-5p	PAR-CLIP	22012620
MIRT527469	hsa-miR-4796-3p	PAR-CLIP	22012620
MIRT527468	hsa-miR-519a-3p	PAR-CLIP	22012620
MIRT527467	hsa-miR-519b-3p	PAR-CLIP	22012620
MIRT527466	hsa-miR-519c-3p	PAR-CLIP	22012620
MIRT527465	hsa-miR-130a-3p	PAR-CLIP	22012620
MIRT527464	hsa-miR-130b-3p	PAR-CLIP	22012620
MIRT527463	hsa-miR-301a-3p	PAR-CLIP	22012620
MIRT527462	hsa-miR-301b-3p	PAR-CLIP	22012620
MIRT527460	hsa-miR-3666	PAR-CLIP	22012620
MIRT527461	hsa-miR-4295	PAR-CLIP	22012620
MIRT527459	hsa-miR-454-3p	PAR-CLIP	22012620
MIRT527458	hsa-miR-556-5p	PAR-CLIP	22012620
MIRT527457	hsa-miR-3160-3p	PAR-CLIP	22012620
MIRT527456	hsa-miR-558	PAR-CLIP	22012620
MIRT527455	hsa-miR-4487	PAR-CLIP	22012620
MIRT709331	hsa-miR-3133	HITS-CLIP	19536157
MIRT709330	hsa-miR-186-5p	HITS-CLIP	19536157
MIRT527479	hsa-miR-3609	HITS-CLIP	19536157
MIRT527478	hsa-miR-548ah-5p	HITS-CLIP	19536157
MIRT527477	hsa-miR-106a-5p	HITS-CLIP	19536157
MIRT527476	hsa-miR-106b-5p	HITS-CLIP	19536157
MIRT527475	hsa-miR-17-5p	HITS-CLIP	19536157
MIRT527474	hsa-miR-20a-5p	HITS-CLIP	19536157
MIRT527473	hsa-miR-20b-5p	HITS-CLIP	19536157
MIRT527472	hsa-miR-519d-3p	HITS-CLIP	19536157
MIRT527471	hsa-miR-526b-3p	HITS-CLIP	19536157
MIRT527470	hsa-miR-93-5p	HITS-CLIP	19536157
MIRT527469	hsa-miR-4796-3p	HITS-CLIP	19536157
MIRT709329	hsa-miR-577	HITS-CLIP	19536157
MIRT527479	hsa-miR-3609	PAR-CLIP	22012620
MIRT527478	hsa-miR-548ah-5p	PAR-CLIP	22012620
MIRT527477	hsa-miR-106a-5p	PAR-CLIP	22012620
MIRT527476	hsa-miR-106b-5p	PAR-CLIP	22012620
MIRT527475	hsa-miR-17-5p	PAR-CLIP	22012620
MIRT527474	hsa-miR-20a-5p	PAR-CLIP	22012620
MIRT527473	hsa-miR-20b-5p	PAR-CLIP	22012620
MIRT527472	hsa-miR-519d-3p	PAR-CLIP	22012620
MIRT527471	hsa-miR-526b-3p	PAR-CLIP	22012620
MIRT527470	hsa-miR-93-5p	PAR-CLIP	22012620
MIRT527469	hsa-miR-4796-3p	PAR-CLIP	22012620
MIRT527468	hsa-miR-519a-3p	PAR-CLIP	22012620
MIRT527467	hsa-miR-519b-3p	PAR-CLIP	22012620
MIRT527466	hsa-miR-519c-3p	PAR-CLIP	22012620
MIRT527465	hsa-miR-130a-3p	PAR-CLIP	22012620
MIRT527464	hsa-miR-130b-3p	PAR-CLIP	22012620
MIRT527463	hsa-miR-301a-3p	PAR-CLIP	22012620
MIRT527462	hsa-miR-301b-3p	PAR-CLIP	22012620
MIRT527460	hsa-miR-3666	PAR-CLIP	22012620
MIRT527461	hsa-miR-4295	PAR-CLIP	22012620
MIRT527459	hsa-miR-454-3p	PAR-CLIP	22012620
MIRT527458	hsa-miR-556-5p	PAR-CLIP	22012620
MIRT527457	hsa-miR-3160-3p	PAR-CLIP	22012620
MIRT527456	hsa-miR-558	PAR-CLIP	22012620
MIRT527455	hsa-miR-4487	PAR-CLIP	22012620
MIRT895614	hsa-miR-1270	CLIP-seq
MIRT895615	hsa-miR-3682-5p	CLIP-seq
MIRT895616	hsa-miR-432	CLIP-seq
MIRT895617	hsa-miR-4434	CLIP-seq
MIRT895618	hsa-miR-4516	CLIP-seq
MIRT895619	hsa-miR-4531	CLIP-seq
MIRT895620	hsa-miR-550b	CLIP-seq
MIRT895621	hsa-miR-620	CLIP-seq
MIRT895622	hsa-miR-1182	CLIP-seq
MIRT895623	hsa-miR-1266	CLIP-seq
MIRT895624	hsa-miR-1287	CLIP-seq
MIRT895625	hsa-miR-1321	CLIP-seq
MIRT895626	hsa-miR-182	CLIP-seq
MIRT895627	hsa-miR-185	CLIP-seq
MIRT895628	hsa-miR-2054	CLIP-seq
MIRT895629	hsa-miR-31	CLIP-seq
MIRT895630	hsa-miR-3135b	CLIP-seq
MIRT895631	hsa-miR-3151	CLIP-seq
MIRT895632	hsa-miR-3664-3p	CLIP-seq
MIRT895633	hsa-miR-370	CLIP-seq
MIRT895634	hsa-miR-4306	CLIP-seq
MIRT895635	hsa-miR-4419a	CLIP-seq
MIRT895636	hsa-miR-4447	CLIP-seq
MIRT895637	hsa-miR-4459	CLIP-seq
MIRT895638	hsa-miR-4472	CLIP-seq
MIRT895639	hsa-miR-4488	CLIP-seq
MIRT895640	hsa-miR-4510	CLIP-seq
MIRT895641	hsa-miR-4518	CLIP-seq
MIRT895642	hsa-miR-4640-5p	CLIP-seq
MIRT895643	hsa-miR-4644	CLIP-seq
MIRT895644	hsa-miR-4645-3p	CLIP-seq
MIRT895645	hsa-miR-4651	CLIP-seq
MIRT895646	hsa-miR-4697-5p	CLIP-seq
MIRT895647	hsa-miR-4726-5p	CLIP-seq
MIRT895648	hsa-miR-4728-5p	CLIP-seq
MIRT895649	hsa-miR-4739	CLIP-seq
MIRT895650	hsa-miR-4756-5p	CLIP-seq
MIRT895651	hsa-miR-4779	CLIP-seq
MIRT895652	hsa-miR-491-5p	CLIP-seq
MIRT895653	hsa-miR-494	CLIP-seq
MIRT895654	hsa-miR-508-3p	CLIP-seq
MIRT895655	hsa-miR-522	CLIP-seq
MIRT895656	hsa-miR-539	CLIP-seq
MIRT895657	hsa-miR-563	CLIP-seq
MIRT895658	hsa-miR-608	CLIP-seq
MIRT1920038	hsa-miR-1915	CLIP-seq
MIRT1920039	hsa-miR-342-3p	CLIP-seq
MIRT1920040	hsa-miR-4446-5p	CLIP-seq
MIRT1920041	hsa-miR-4477a	CLIP-seq
MIRT1920042	hsa-miR-4528	CLIP-seq
MIRT1920043	hsa-miR-4726-3p	CLIP-seq
MIRT1920044	hsa-miR-4775	CLIP-seq
MIRT1920045	hsa-miR-590-3p	CLIP-seq
MIRT1920038	hsa-miR-1915	CLIP-seq
MIRT1920039	hsa-miR-342-3p	CLIP-seq
MIRT1920040	hsa-miR-4446-5p	CLIP-seq
MIRT1920041	hsa-miR-4477a	CLIP-seq
MIRT1920042	hsa-miR-4528	CLIP-seq
MIRT1920043	hsa-miR-4726-3p	CLIP-seq
MIRT1920044	hsa-miR-4775	CLIP-seq
MIRT1920045	hsa-miR-590-3p	CLIP-seq
MIRT1920038	hsa-miR-1915	CLIP-seq
MIRT1920039	hsa-miR-342-3p	CLIP-seq
MIRT1920040	hsa-miR-4446-5p	CLIP-seq
MIRT1920041	hsa-miR-4477a	CLIP-seq
MIRT1920042	hsa-miR-4528	CLIP-seq
MIRT1920043	hsa-miR-4726-3p	CLIP-seq
MIRT1920044	hsa-miR-4775	CLIP-seq
MIRT1920045	hsa-miR-590-3p	CLIP-seq
MIRT1920038	hsa-miR-1915	CLIP-seq
MIRT1920039	hsa-miR-342-3p	CLIP-seq
MIRT1920040	hsa-miR-4446-5p	CLIP-seq
MIRT1920041	hsa-miR-4477a	CLIP-seq
MIRT1920042	hsa-miR-4528	CLIP-seq
MIRT1920043	hsa-miR-4726-3p	CLIP-seq
MIRT1920044	hsa-miR-4775	CLIP-seq
MIRT1920045	hsa-miR-590-3p	CLIP-seq
MIRT1965548	hsa-miR-1229	CLIP-seq
MIRT1965549	hsa-miR-218	CLIP-seq
MIRT1965550	hsa-miR-3140-3p	CLIP-seq
MIRT1920039	hsa-miR-342-3p	CLIP-seq
MIRT1965551	hsa-miR-3664-5p	CLIP-seq
MIRT1965552	hsa-miR-374a	CLIP-seq
MIRT1965553	hsa-miR-374b	CLIP-seq
MIRT1920042	hsa-miR-4528	CLIP-seq
MIRT1965554	hsa-miR-4714-5p	CLIP-seq
MIRT1965555	hsa-miR-4742-3p	CLIP-seq
MIRT1965556	hsa-miR-616	CLIP-seq
MIRT1965557	hsa-miR-636	CLIP-seq

Gene ontology (GO) Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002769	Process	Natural killer cell inhibitory signaling pathway	IBA
GO:0002769	Process	Natural killer cell inhibitory signaling pathway	IMP	17562706
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IEA
GO:0009897	Component	External side of plasma membrane	IBA
GO:0009897	Component	External side of plasma membrane	IMP	17562706
GO:0016020	Component	Membrane	IEA
GO:0019903	Function	Protein phosphatase binding	IBA
GO:0019903	Function	Protein phosphatase binding	IDA	34310951
GO:0019903	Function	Protein phosphatase binding	IPI	17562706
GO:0030246	Function	Carbohydrate binding	IEA
GO:0030545	Function	Signaling receptor regulator activity	IEA
GO:0030547	Function	Signaling receptor inhibitor activity	IMP	17562706
GO:0032991	Component	Protein-containing complex	IMP	17562706
GO:0045953	Process	Negative regulation of natural killer cell mediated cytotoxicity	IMP	17562706
GO:0097325	Process	Melanocyte proliferation	IDA	34310951
GO:1904893	Process	Negative regulation of receptor signaling pathway via STAT	IDA	34310951
GO:2000272	Process	Negative regulation of signaling receptor activity	IMP	17562706

Other IDs

• MIM: 617573
• HGNC: 31966
• e!Ensembl: ENSG00000256660

Protein

• UniProt ID: Q2HXU8
• Protein name: C-type lectin domain family 12 member B (Macrophage antigen H)
• Protein function: Inhibitory receptor postulated to negatively regulate immune and non-immune functions (PubMed:17562706, PubMed:34310951). Upon phosphorylation, recruits SH2 domain-containing PTPN6 and PTPN11 phosphatases to its ITIM motif and antagonizes activa
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00059	Lectin_C	161 → 265	Lectin C-type domain	Domain
  PF08391	Ly49	36 → 157	Ly49-like protein, N-terminal region	Family

• Tissue specificity: TISSUE SPECIFICITY: Detected in colon, heart, kidney, liver, lung, mammary gland, ovary, spleen and testis (PubMed:17562706). Expressed in melanocytes (at protein level) (PubMed:34310951). {ECO:0000269|PubMed:17562706, ECO:0000269|PubMed:34310951}.
• Sequence:

  MSEEVTYATLTFQDSAGARNNRDGNNLRKRGHPAPSPIWRHAALGLVTLCLMLLIGLVTL
  GMMFLQISNDINSDSEKLSQLQKTIQQQQDNLSQQLGNSNNLSMEEEFLKSQISSVLKRQ
  EQMAIKLCQELIIHTSDHRCNPCPKMWQWYQNSCYYFTTNEEKTWANSRKDCIDKNSTLV
  KIDSLEEKDFLMSQPLLMFSFFWLGLSWDSSGRSWFWEDGSVPSPSLFSTKELDQINGSK
  GCAYFQKGNIYISRCSAEIFWICEKTAAPVKTEDLD

• Sequence length: 276

Related Genes

No strongly related genes found yet for CLEC12B.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to CLEC12B.