CIP2A (cellular inhibitor of PP2A)

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Gene Gene information from NCBI Gene database.
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Entrez ID 57650
Gene name Cellular inhibitor of PP2A
Gene symbol CIP2A
Synonyms (NCBI Gene)
KIAA1524NOCIVAp90
Chromosome 3
Chromosome location 3q13.13
miRNA miRNA information provided by mirtarbase database.
1
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miRTarBase ID miRNA Experiments Reference
MIRT737188 hsa-miR-301a-3p Luciferase reporter assayWestern blottingMicroarrayImmunoprecipitaion (IP)RNA-seqqRT-PCR 31762806
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
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Transcription factor Regulation Reference
ETS1 Activation 24280132
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16 Show/Hide all (16)
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GO ID Ontology Definition Evidence Reference
GO:0004864 Function Protein phosphatase inhibitor activity IDA 17632056
GO:0005515 Function Protein binding IPI 17632056, 28174209, 35121901, 35842428, 37165191, 37316668
GO:0005694 Component Chromosome IDA 35121901, 35842428, 37165191, 37316668
GO:0005694 Component Chromosome IEA
GO:0005737 Component Cytoplasm IDA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
610643 29302 ENSG00000163507
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8TCG1
Protein name Protein CIP2A (Cancerous inhibitor of PP2A) (p90 autoantigen)
Protein function Acts as an inhibitor of protein phosphatase PP2A (PubMed:17632056). Promotes anchorage-independent cell growth and tumor formation by preventing dephosphorylation of MYC, thereby stabilizing MYC in human malignancies (PubMed:17632056). Together
PDB 5UFL
Family and domains
Tissue specificity TISSUE SPECIFICITY: Expressed at low levels in most of the tissues. Overexpressed in head-and-neck squamous cell carcinomas (HNSCC). Present in liver cancer cells (at protein level). {ECO:0000269|PubMed:12118381, ECO:0000269|PubMed:17632056}.
Sequence 
MDSTACLKSLLLTVSQYKAVKSEANATQLLRHLEVISGQKLTRLFTSNQILTSECLSCLV
ELLEDPNISASLILSIIGLLSQLAVDIETRDCLQNTYNLNSVLAGVVCRSSHTDSVFLQC
IQLLQKLTYNVKIFYSGANIDELITFLIDHIQSSEDELKMPCLGLLANLCRHNLSVQTHI
KTLSNVKSFYRTLITLLAHSSLTVVVFALSILSSLTLNEEVGEKLFHARNIHQTFQLIFN
ILINGDGTLTRKYSVDLLMDLLKNPKIADYLTRYEHFSSCLHQVLGLLNGKDPDSSSKVL
ELLLAFCSVTQLRHMLTQMMFEQSPPGSATLGSHTKCLEPTVALLRWLSQPLDGSENCSV
LALELFKEIFEDVIDAANCSSADRFVTLLLPTILDQLQFTEQNLDEALTRKKCERIAKAI
EVLLTLCGDDTLKMHIAKILTTVKCTTLIEQQFTYGKIDLGFGTKVADSELCKLAADVIL
KTLDLINKLKPLVPGMEVSFYKILQDPRLITPLAFALTSDNREQVQSGLRILLEAAPLPD
FPALVLGESIAANNAYRQQETEHIPRKMPWQSSNHSFPTSIKCLTPHLKDGVPGLNIEEL
IEKLQSGMVVKDQICDVRISDIMDVYEMKLSTLASKESRLQDLLETKALALAQADRLIAQ
HRCQRTQAETEARTLASMLREVERKNEELSVLLKAQQVESERAQSDIEHLFQHNRKLESV
AEEHEILTKSYMELLQRNESTEKKNKDLQITCDSLNKQIETVKKLNESLKEQNEKSIAQL
IEKEEQRKEVQNQLVDREHKLANLHQKTKVQEEKIKTLQKEREDKEETIDILRKELSRTE
QIRKELSIKASSLEVQKAQLEGRLEEKESLVKLQQEELNKHSHMIAMIHSLSGGKINPET
VNLSI
Sequence length 905
Interactions View interactions

No strongly related genes found yet for CIP2A.

No additional diseases found yet through genes similar to CIP2A.