CHRAC1 (chromatin accessibility complex subunit 1)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 54108 |
| Gene name | Chromatin accessibility complex subunit 1 |
| Gene symbol | CHRAC1 |
| Synonyms (NCBI Gene) |
CHARC1CHARC15CHRAC-1CHRAC-15CHRAC15YCL1
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| Chromosome | 8 |
| Chromosome location | 8q24.3 |
| Summary | CHRAC1 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[s |
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miRNA
miRNA information provided by mirtarbase database.
384
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9NRG0 | ||||||||||
| Protein name | Chromatin accessibility complex protein 1 (CHRAC-1) (Chromatin accessibility complex 15 kDa protein) (CHRAC-15) (HuCHRAC15) (DNA polymerase epsilon subunit p15) | ||||||||||
| Protein function | Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:10880450}. | ||||||||||
| Sequence |
MADVVVGKDKGGEQRLISLPLSRIRVIMKSSPEVSSINQEALVLTAKATELFVQCLATYS |
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| Sequence length | 131 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Related Genes
Genes most often co-reported with CHRAC1 across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to CHRAC1 (see Related Genes above), that are NOT already directly curated for CHRAC1 itself -- a lead worth checking, not a confirmed association.
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