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Gene Gene information from NCBI Gene database.
Entrez ID 54108
Gene name Chromatin accessibility complex subunit 1
Gene symbol CHRAC1
Synonyms (NCBI Gene)
CHARC1CHARC15CHRAC-1CHRAC-15CHRAC15YCL1
Chromosome 8
Chromosome location 8q24.3
Summary CHRAC1 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[s
miRNA miRNA information provided by mirtarbase database.
384 Show/Hide all (384)
miRTarBase ID miRNA Experiments Reference
MIRT020660 hsa-miR-155-5p Proteomics 18668040
MIRT022520 hsa-miR-124-3p Proteomics;Microarray 18668037
MIRT023751 hsa-miR-1-3p Proteomics;Microarray 18668037
MIRT032287 hsa-let-7b-5p Proteomics 18668040
MIRT050214 hsa-miR-25-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
22 Show/Hide all (22)
GO ID Ontology Definition Evidence Reference
GO:0003677 Function DNA binding IEA
GO:0003677 Function DNA binding NAS 10880450
GO:0003887 Function DNA-directed DNA polymerase activity IEA
GO:0003887 Function DNA-directed DNA polymerase activity NAS 10880450
GO:0005515 Function Protein binding IPI 21516116, 25416956, 31515488, 32296183, 33961781
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607268 13544 ENSG00000104472
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NRG0
Protein name Chromatin accessibility complex protein 1 (CHRAC-1) (Chromatin accessibility complex 15 kDa protein) (CHRAC-15) (HuCHRAC15) (DNA polymerase epsilon subunit p15)
Protein function Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00808 CBFD_NFYB_HMF 17 → 80 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:10880450}.
Sequence
MADVVVGKDKGGEQRLISLPLSRIRVIMKSSPEVSSINQEALVLTAKATELFVQCLATYS
YRHGSGKEKKVLTYSDLANT
AQQSETFQFLADILPKKILASKYLKMLKEEKREEDEENDN
DNESDHDEADS
Sequence length 131
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway
ATP-dependent chromatin remodeling