Gene ontology (GO)Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
Probable ATP-dependent chromatin-remodeling factor. Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in
TISSUE SPECIFICITY: Widely expressed at low levels. In bone marrow, expression is restricted to osteoprogenitor cells adjacent to mature osteoblasts. {ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:16554032}.
Evidence Score:★☆☆☆☆ Gene-disease association found in Text Mining only★★☆☆☆ Found in Text Mining and Unknown/Other Associations★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations
ClinVar entries with uncertain/conflicting evidence, and associations from other databases
(OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
["PPARA activates gene expression","Transcriptional regulation of white adipocyte differentiation","RORA activates gene expression","Transcriptional activation of mitochondrial biogenesis","Activation of gene expression by SREBF (SREBP)","Regulation of lipid metabolism by PPARalpha","Circadian Clock"]
["PPARA activates gene expression","Transcriptional regulation of white adipocyte differentiation","RORA activates gene expression","Transcriptional activation of mitochondrial biogenesis","Activation of gene expression by SREBF (SREBP)","Regulation of lipid metabolism by PPARalpha","Circadian Clock"]
["PPARA activates gene expression","Transcriptional regulation of white adipocyte differentiation","RORA activates gene expression","Transcriptional activation of mitochondrial biogenesis","Activation of gene expression by SREBF (SREBP)","Regulation of lipid metabolism by PPARalpha","Circadian Clock"]
["PPARA activates gene expression","Transcriptional regulation of white adipocyte differentiation","RORA activates gene expression","Transcriptional activation of mitochondrial biogenesis","Activation of gene expression by SREBF (SREBP)","Regulation of lipid metabolism by PPARalpha","Circadian Clock"]
["PPARA activates gene expression","Transcriptional regulation of white adipocyte differentiation","RORA activates gene expression","Transcriptional activation of mitochondrial biogenesis","Activation of gene expression by SREBF (SREBP)","Regulation of lipid metabolism by PPARalpha","Circadian Clock"]
0
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Diseases Linked via Similar GenesDiseases curated for genes most similar to CHD9 (see Related Genes above), that are NOT already directly curated for CHD9 itself -- a lead worth checking, not a confirmed association.