CHCHD4 (coiled-coil-helix-coiled-coil-helix domain containing 4)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 131474
• Gene name: Coiled-coil-helix-coiled-coil-helix domain containing 4
• Gene symbol: CHCHD4
• Synonyms (NCBI Gene): MIA40, TIMM40
• Chromosome: 3
• Chromosome location: 3p25.1
• Summary: CHCHD4, a component of human mitochondria, belongs to a protein family whose members share 6 highly conserved cysteine residues constituting a -CXC-CX(9)C-CX(9)C- motif in the C terminus (Hofmann et al., 2005 [PubMed 16185709]).[supplied by OMIM, Mar 2008

miRNA Show/Hide all (144)

miRTarBase ID	miRNA	Experiments	Reference
MIRT043892	hsa-miR-378a-3p	CLASH	23622248
MIRT720321	hsa-miR-199a-5p	HITS-CLIP	19536157
MIRT720320	hsa-miR-199b-5p	HITS-CLIP	19536157
MIRT720319	hsa-miR-4676-5p	HITS-CLIP	19536157
MIRT720318	hsa-miR-575	HITS-CLIP	19536157
MIRT720317	hsa-miR-4302	HITS-CLIP	19536157
MIRT720316	hsa-miR-6761-5p	HITS-CLIP	19536157
MIRT720315	hsa-miR-874-5p	HITS-CLIP	19536157
MIRT720314	hsa-miR-296-5p	HITS-CLIP	19536157
MIRT720313	hsa-miR-6724-5p	HITS-CLIP	19536157
MIRT720312	hsa-miR-6773-5p	HITS-CLIP	19536157
MIRT704721	hsa-miR-3690	HITS-CLIP	23313552
MIRT704720	hsa-miR-4638-3p	HITS-CLIP	23313552
MIRT704719	hsa-miR-1254	HITS-CLIP	23313552
MIRT704718	hsa-miR-3116	HITS-CLIP	23313552
MIRT704717	hsa-miR-4633-5p	HITS-CLIP	23313552
MIRT704716	hsa-miR-6807-5p	HITS-CLIP	23313552
MIRT648536	hsa-miR-4781-3p	HITS-CLIP	23824327
MIRT648537	hsa-miR-136-5p	HITS-CLIP	23824327
MIRT648535	hsa-miR-6505-3p	HITS-CLIP	23824327
MIRT648534	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT648533	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT648532	hsa-miR-653-5p	HITS-CLIP	23824327
MIRT571299	hsa-miR-302f	PAR-CLIP	20371350
MIRT571298	hsa-miR-219b-3p	PAR-CLIP	20371350
MIRT571297	hsa-miR-873-3p	PAR-CLIP	20371350
MIRT571296	hsa-miR-5008-5p	PAR-CLIP	20371350
MIRT571295	hsa-miR-6089	PAR-CLIP	20371350
MIRT571294	hsa-miR-4743-5p	PAR-CLIP	20371350
MIRT571292	hsa-miR-3672	PAR-CLIP	20371350
MIRT571293	hsa-miR-6864-3p	PAR-CLIP	20371350
MIRT571291	hsa-miR-6765-5p	PAR-CLIP	20371350
MIRT571290	hsa-miR-1273e	PAR-CLIP	20371350
MIRT571289	hsa-miR-1304-5p	PAR-CLIP	20371350
MIRT720321	hsa-miR-199a-5p	HITS-CLIP	19536157
MIRT720320	hsa-miR-199b-5p	HITS-CLIP	19536157
MIRT720319	hsa-miR-4676-5p	HITS-CLIP	19536157
MIRT720318	hsa-miR-575	HITS-CLIP	19536157
MIRT720317	hsa-miR-4302	HITS-CLIP	19536157
MIRT720316	hsa-miR-6761-5p	HITS-CLIP	19536157
MIRT720315	hsa-miR-874-5p	HITS-CLIP	19536157
MIRT720314	hsa-miR-296-5p	HITS-CLIP	19536157
MIRT720313	hsa-miR-6724-5p	HITS-CLIP	19536157
MIRT720312	hsa-miR-6773-5p	HITS-CLIP	19536157
MIRT704721	hsa-miR-3690	HITS-CLIP	23313552
MIRT704720	hsa-miR-4638-3p	HITS-CLIP	23313552
MIRT704719	hsa-miR-1254	HITS-CLIP	23313552
MIRT704718	hsa-miR-3116	HITS-CLIP	23313552
MIRT704717	hsa-miR-4633-5p	HITS-CLIP	23313552
MIRT704716	hsa-miR-6807-5p	HITS-CLIP	23313552
MIRT648536	hsa-miR-4781-3p	HITS-CLIP	23824327
MIRT648537	hsa-miR-136-5p	HITS-CLIP	23824327
MIRT648535	hsa-miR-6505-3p	HITS-CLIP	23824327
MIRT648534	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT648533	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT648532	hsa-miR-653-5p	HITS-CLIP	23824327
MIRT571299	hsa-miR-302f	PAR-CLIP	20371350
MIRT571298	hsa-miR-219b-3p	PAR-CLIP	20371350
MIRT571297	hsa-miR-873-3p	PAR-CLIP	20371350
MIRT571296	hsa-miR-5008-5p	PAR-CLIP	20371350
MIRT571295	hsa-miR-6089	PAR-CLIP	20371350
MIRT571294	hsa-miR-4743-5p	PAR-CLIP	20371350
MIRT571292	hsa-miR-3672	PAR-CLIP	20371350
MIRT571293	hsa-miR-6864-3p	PAR-CLIP	20371350
MIRT571291	hsa-miR-6765-5p	PAR-CLIP	20371350
MIRT571290	hsa-miR-1273e	PAR-CLIP	20371350
MIRT571289	hsa-miR-1304-5p	PAR-CLIP	20371350
MIRT888674	hsa-miR-1245b-5p	CLIP-seq
MIRT888675	hsa-miR-1252	CLIP-seq
MIRT888676	hsa-miR-3142	CLIP-seq
MIRT888677	hsa-miR-3149	CLIP-seq
MIRT888678	hsa-miR-3202	CLIP-seq
MIRT888679	hsa-miR-374a	CLIP-seq
MIRT888680	hsa-miR-374b	CLIP-seq
MIRT888681	hsa-miR-3922-5p	CLIP-seq
MIRT888682	hsa-miR-4276	CLIP-seq
MIRT888683	hsa-miR-432	CLIP-seq
MIRT888684	hsa-miR-4436a	CLIP-seq
MIRT888685	hsa-miR-4496	CLIP-seq
MIRT888686	hsa-miR-4533	CLIP-seq
MIRT888687	hsa-miR-4700-3p	CLIP-seq
MIRT888688	hsa-miR-568	CLIP-seq
MIRT888689	hsa-miR-578	CLIP-seq
MIRT888690	hsa-miR-656	CLIP-seq
MIRT888691	hsa-miR-1197	CLIP-seq
MIRT888692	hsa-miR-1225-5p	CLIP-seq
MIRT888693	hsa-miR-3132	CLIP-seq
MIRT888694	hsa-miR-4464	CLIP-seq
MIRT888695	hsa-miR-4748	CLIP-seq
MIRT888696	hsa-miR-4762-5p	CLIP-seq
MIRT2199847	hsa-miR-28-5p	CLIP-seq
MIRT2199848	hsa-miR-3139	CLIP-seq
MIRT2199849	hsa-miR-3670	CLIP-seq
MIRT2199850	hsa-miR-548aa	CLIP-seq
MIRT2199851	hsa-miR-665	CLIP-seq
MIRT2199852	hsa-miR-708	CLIP-seq
MIRT888691	hsa-miR-1197	CLIP-seq
MIRT888692	hsa-miR-1225-5p	CLIP-seq
MIRT2502469	hsa-miR-21	CLIP-seq
MIRT2502470	hsa-miR-3065-3p	CLIP-seq
MIRT888693	hsa-miR-3132	CLIP-seq
MIRT2502471	hsa-miR-3158-3p	CLIP-seq
MIRT2502472	hsa-miR-3194-5p	CLIP-seq
MIRT2502473	hsa-miR-3669	CLIP-seq
MIRT888682	hsa-miR-4276	CLIP-seq
MIRT2502474	hsa-miR-4287	CLIP-seq
MIRT2502475	hsa-miR-4291	CLIP-seq
MIRT2502476	hsa-miR-4457	CLIP-seq
MIRT888694	hsa-miR-4464	CLIP-seq
MIRT2502477	hsa-miR-4469	CLIP-seq
MIRT2502478	hsa-miR-4663	CLIP-seq
MIRT2502479	hsa-miR-4685-3p	CLIP-seq
MIRT2502480	hsa-miR-4685-5p	CLIP-seq
MIRT888695	hsa-miR-4748	CLIP-seq
MIRT2502481	hsa-miR-4789-3p	CLIP-seq
MIRT2502482	hsa-miR-513b	CLIP-seq
MIRT2502483	hsa-miR-555	CLIP-seq
MIRT2502484	hsa-miR-590-5p	CLIP-seq
MIRT2502485	hsa-miR-628-5p	CLIP-seq
MIRT2502486	hsa-miR-635	CLIP-seq
MIRT888691	hsa-miR-1197	CLIP-seq
MIRT888692	hsa-miR-1225-5p	CLIP-seq
MIRT2502469	hsa-miR-21	CLIP-seq
MIRT2502470	hsa-miR-3065-3p	CLIP-seq
MIRT888693	hsa-miR-3132	CLIP-seq
MIRT2502471	hsa-miR-3158-3p	CLIP-seq
MIRT2502472	hsa-miR-3194-5p	CLIP-seq
MIRT2502473	hsa-miR-3669	CLIP-seq
MIRT888682	hsa-miR-4276	CLIP-seq
MIRT2502474	hsa-miR-4287	CLIP-seq
MIRT2502475	hsa-miR-4291	CLIP-seq
MIRT2502476	hsa-miR-4457	CLIP-seq
MIRT888694	hsa-miR-4464	CLIP-seq
MIRT2502477	hsa-miR-4469	CLIP-seq
MIRT2502478	hsa-miR-4663	CLIP-seq
MIRT2502479	hsa-miR-4685-3p	CLIP-seq
MIRT2502480	hsa-miR-4685-5p	CLIP-seq
MIRT888695	hsa-miR-4748	CLIP-seq
MIRT2502481	hsa-miR-4789-3p	CLIP-seq
MIRT2502482	hsa-miR-513b	CLIP-seq
MIRT2502483	hsa-miR-555	CLIP-seq
MIRT2502484	hsa-miR-590-5p	CLIP-seq
MIRT2502485	hsa-miR-628-5p	CLIP-seq
MIRT2502486	hsa-miR-635	CLIP-seq

Gene ontology (GO) Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	19182799, 23676665, 26004228, 26387864, 28040730, 30885959
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA	23676665, 24101517
GO:0005739	Component	Mitochondrion	IEA
GO:0005758	Component	Mitochondrial intermembrane space	IBA
GO:0005758	Component	Mitochondrial intermembrane space	IDA	26004228
GO:0005758	Component	Mitochondrial intermembrane space	IEA
GO:0005758	Component	Mitochondrial intermembrane space	IMP	37159021
GO:0015031	Process	Protein transport	IEA
GO:0015035	Function	Protein-disulfide reductase activity	IBA
GO:0015035	Function	Protein-disulfide reductase activity	IDA	26387864
GO:0015035	Function	Protein-disulfide reductase activity	IEA
GO:0015035	Function	Protein-disulfide reductase activity	IMP	19182799, 23676665, 37159021
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0033108	Process	Mitochondrial respiratory chain complex assembly	IEA
GO:0033108	Process	Mitochondrial respiratory chain complex assembly	IMP	26004228
GO:0045041	Process	Protein import into mitochondrial intermembrane space	IBA
GO:0045041	Process	Protein import into mitochondrial intermembrane space	IEA
GO:0051604	Process	Protein maturation	IBA
GO:0072655	Process	Establishment of protein localization to mitochondrion	IEA
GO:0160203	Process	Mitochondrial disulfide relay system	IMP	21059946, 23676665, 37159021

Other IDs

• MIM: 611077
• HGNC: 26467
• e!Ensembl: ENSG00000163528

Protein

• UniProt ID: Q8N4Q1
• Protein name: Mitochondrial intermembrane space import and assembly protein 40 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 4)
• Protein function: Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes (PubMed:26004228). Functions as chaperone and catalyzes the formation of disulfide bond
• PDB: 2K3J , 2L0Y , 8VGY
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06747	CHCH	64 → 100	CHCH domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in all tissues tested, suggesting an ubiquitous expression. {ECO:0000269|PubMed:16185709}.
• Sequence:

  MSYCRQEGKDRIIFVTKEDHETPSSAELVADDPNDPYEEHGLILPNGNINWNCPCLGGMA
  SGPCGEQFKSAFSCFHYSTEEIKGSDCVDQFRAMQECMQKYPDLYPQEDEDEEEEREKKP
  AEQAEETAPIEATATKEEEGSS

• Sequence length: 142

Related Genes

No strongly related genes found yet for CHCHD4.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to CHCHD4.