Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	22832
Gene name	Centrosomal protein 162
Gene symbol	CEP162
Synonyms (NCBI Gene)	C6orf84KIAA1009QN1
Chromosome	6
Chromosome location	6q14.2-q14.3

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miRTarBase ID	miRNA	Experiments	Reference
MIRT626866	hsa-miR-8485	HITS-CLIP	23824327
MIRT626865	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT626864	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT626863	hsa-miR-603	HITS-CLIP	23824327
MIRT626862	hsa-miR-3065-3p	HITS-CLIP	23824327
MIRT626861	hsa-miR-3941	HITS-CLIP	23824327
MIRT495322	hsa-miR-6856-3p	PAR-CLIP	23708386
MIRT495321	hsa-miR-6504-3p	PAR-CLIP	23708386
MIRT495320	hsa-miR-520d-5p	PAR-CLIP	23708386
MIRT495319	hsa-miR-524-5p	PAR-CLIP	23708386
MIRT461493	hsa-miR-1246	PAR-CLIP	23592263
MIRT461492	hsa-miR-1245b-3p	PAR-CLIP	23592263
MIRT461491	hsa-miR-383-5p	PAR-CLIP	23592263
MIRT461490	hsa-miR-3134	PAR-CLIP	23592263
MIRT461489	hsa-miR-4320	PAR-CLIP	23592263
MIRT461488	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT461487	hsa-miR-27a-3p	PAR-CLIP	23592263
MIRT461486	hsa-miR-27b-3p	PAR-CLIP	23592263
MIRT742427	hsa-miR-8485	HITS-CLIP	23824327
MIRT742428	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT742429	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT742430	hsa-miR-603	HITS-CLIP	23824327
MIRT742431	hsa-miR-3065-3p	HITS-CLIP	23824327
MIRT742432	hsa-miR-3941	HITS-CLIP	23824327
MIRT754819	hsa-miR-6856-3p	PAR-CLIP	23708386
MIRT754820	hsa-miR-6504-3p	PAR-CLIP	23708386
MIRT754821	hsa-miR-520d-5p	PAR-CLIP	23708386
MIRT754822	hsa-miR-524-5p	PAR-CLIP	23708386
MIRT755127	hsa-miR-1246	PAR-CLIP	23592263
MIRT755128	hsa-miR-1245b-3p	PAR-CLIP	23592263
MIRT755129	hsa-miR-383-5p	PAR-CLIP	23592263
MIRT755130	hsa-miR-3134	PAR-CLIP	23592263
MIRT755131	hsa-miR-4320	PAR-CLIP	23592263
MIRT755132	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT755133	hsa-miR-27a-3p	PAR-CLIP	23592263
MIRT755134	hsa-miR-27b-3p	PAR-CLIP	23592263

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	23644468, 26638075
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005813	Component	Centrosome	IDA	21399614
GO:0005814	Component	Centriole	IBA
GO:0005814	Component	Centriole	IDA	23644468
GO:0005814	Component	Centriole	IEA
GO:0005819	Component	Spindle	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0005879	Component	Axonemal microtubule	IBA
GO:0005879	Component	Axonemal microtubule	IDA	23644468
GO:0030030	Process	Cell projection organization	IEA
GO:0034451	Component	Centriolar satellite	IBA
GO:0034451	Component	Centriolar satellite	IDA
GO:0036064	Component	Ciliary basal body	IDA
GO:0060271	Process	Cilium assembly	IBA
GO:0060271	Process	Cilium assembly	IMP	23644468

MIM	HGNC	e!Ensembl
610201	21107	ENSG00000135315

Q5TB80

Protein name

Centrosomal protein of 162 kDa (Cep162) (Protein QN1 homolog)

Protein function

Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubul

Family and domains

Sequence

MANCSQEELDEEFEQFMKELSDDSFENSDKTARQSKKEMKKKDTVPWWITEDDFKDDGLL
GTNVSYLKTKKTSQPVMEIEEESAEKIQFLKSSGTSLLSTDSLETNELVVSELNHSSLGV
GLDTLEEQEEKEQFFARLEKGLTSSIDYSRLNKELDSNDSTHFKALHSNQANAELTDDEH
ENESKHEELAENYSDDFEDEYVGAPLTTKDEEMPSKENSKSEKISVPKQEEEKTGMLANV
VLLDSLDSVAEVNLDEQDKITPKPRCLPEMTENEMTGTGVSYGQSSSDVEALHQAYCHIA
HSLGDEDKQKIESNTVEDIKSSVKGHPQENEENSKNISTMESDLPTVEELMKPIRIDSFG
ISGFDLQPVSSEKVAERKETEFFSSLPLKMNPNILSQDSQHVNLFFDKNDENVILQKTTN
ESMENSCPQVTEVTATEEHVDKMYLNILRKKITVNSSSLSQDDKINKTYRSQLSSEEEGA
VMGKQVPYKKARSAPPLLKRKPQSGLYASVRSSGYGKPSSPLKMFSTLEKKTSEDIIKSK
NLRSISTSNQPRKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENPTETDSCIQFQTD
SLGYCGENKEKKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKEKELENKLEELKKQQEK
ELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLLQGY
QQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTR
NQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEK
LYEIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAES
GNPSIRQKIRLKDKAADAKKIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKN
TVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHD
SPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQ
AHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVL
HSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEAV
MNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNRKIATQEVLI
RHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIK
QMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKFRTELDSILDVL
RELHRQGVVVPVAFADEMNAPEY

Sequence length

1403

Interactions

View interactions

Reactome Pathway
Anchoring of the basal body to the plasma membrane

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BREAST CANCER	—	GWAS catalog	29059683	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	29059683	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE SCLEROSIS	—	GWAS catalog	39024449	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	31504550	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, KNEE	—	GWAS catalog	40205036	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Diabetic Retinopathy	Diabetic retinopathy	Pubtator	25364816	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

Related Genes Genes most often co-reported with CEP162 across shared curated disease and pathway associations. 0 Download as csv Download as pdf
No strongly related genes found yet for CEP162.

Diseases Linked via Similar Genes Diseases curated for genes most similar to CEP162 (see Related Genes above), that are NOT already directly curated for CEP162 itself -- a lead worth checking, not a confirmed association. 0 Download as csv Download as pdf
No additional diseases found yet through genes similar to CEP162.

CEP162 (centrosomal protein 162)

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