CEND1 (cell cycle exit and neuronal differentiation 1)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 51286
• Gene name: Cell cycle exit and neuronal differentiation 1
• Gene symbol: CEND1
• Synonyms (NCBI Gene): BM88
• Chromosome: 11
• Chromosome location: 11p15.5
• Summary: The protein encoded by this gene is a neuron-specific protein. The similar protein in pig enhances neuroblastoma cell differentiation in vitro and may be involved in neuronal differentiation in vivo. Multiple pseudogenes have been reported for this gene.

miRNA Show/Hide all (58)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018322	hsa-miR-335-5p	Microarray	18185580
MIRT029783	hsa-miR-26b-5p	Microarray	19088304
MIRT053430	hsa-miR-512-5p	Microarray	23807165
MIRT884582	hsa-miR-1207-5p	CLIP-seq
MIRT884583	hsa-miR-1224-3p	CLIP-seq
MIRT884584	hsa-miR-1256	CLIP-seq
MIRT884585	hsa-miR-125a-3p	CLIP-seq
MIRT884586	hsa-miR-1260	CLIP-seq
MIRT884587	hsa-miR-1260b	CLIP-seq
MIRT884588	hsa-miR-1280	CLIP-seq
MIRT884589	hsa-miR-1304	CLIP-seq
MIRT884590	hsa-miR-188-3p	CLIP-seq
MIRT884591	hsa-miR-2467-5p	CLIP-seq
MIRT884592	hsa-miR-3127-5p	CLIP-seq
MIRT884593	hsa-miR-3141	CLIP-seq
MIRT884594	hsa-miR-3150a-3p	CLIP-seq
MIRT884595	hsa-miR-3151	CLIP-seq
MIRT884596	hsa-miR-3156-3p	CLIP-seq
MIRT884597	hsa-miR-3175	CLIP-seq
MIRT884598	hsa-miR-3188	CLIP-seq
MIRT884599	hsa-miR-3194-3p	CLIP-seq
MIRT884600	hsa-miR-320e	CLIP-seq
MIRT884601	hsa-miR-3689d	CLIP-seq
MIRT884602	hsa-miR-3907	CLIP-seq
MIRT884603	hsa-miR-3918	CLIP-seq
MIRT884604	hsa-miR-3934	CLIP-seq
MIRT884605	hsa-miR-3975	CLIP-seq
MIRT884606	hsa-miR-4447	CLIP-seq
MIRT884607	hsa-miR-4472	CLIP-seq
MIRT884608	hsa-miR-4731-5p	CLIP-seq
MIRT884609	hsa-miR-4763-3p	CLIP-seq
MIRT884610	hsa-miR-4781-5p	CLIP-seq
MIRT884611	hsa-miR-485-5p	CLIP-seq
MIRT884612	hsa-miR-486-3p	CLIP-seq
MIRT884613	hsa-miR-491-5p	CLIP-seq
MIRT884614	hsa-miR-744	CLIP-seq
MIRT884615	hsa-miR-760	CLIP-seq
MIRT884616	hsa-miR-764	CLIP-seq
MIRT884617	hsa-miR-939	CLIP-seq
MIRT1920037	hsa-miR-1249	CLIP-seq
MIRT1920037	hsa-miR-1249	CLIP-seq
MIRT1920037	hsa-miR-1249	CLIP-seq
MIRT1962344	hsa-miR-1273d	CLIP-seq
MIRT1962345	hsa-miR-4651	CLIP-seq
MIRT1962346	hsa-miR-608	CLIP-seq
MIRT2198765	hsa-miR-3173-3p	CLIP-seq
MIRT2198766	hsa-miR-4428	CLIP-seq
MIRT2198767	hsa-miR-4521	CLIP-seq
MIRT2198768	hsa-miR-4639-5p	CLIP-seq
MIRT2385928	hsa-miR-4292	CLIP-seq
MIRT2385929	hsa-miR-4793-3p	CLIP-seq
MIRT2385930	hsa-miR-637	CLIP-seq
MIRT2446841	hsa-miR-3065-3p	CLIP-seq
MIRT2446842	hsa-miR-4640-3p	CLIP-seq
MIRT2446843	hsa-miR-635	CLIP-seq
MIRT2446841	hsa-miR-3065-3p	CLIP-seq
MIRT2446842	hsa-miR-4640-3p	CLIP-seq
MIRT2446843	hsa-miR-635	CLIP-seq

Gene ontology (GO) Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	30177828, 32296183
GO:0005739	Component	Mitochondrion	IDA	11311134
GO:0007628	Process	Adult walking behavior	IEA
GO:0016020	Component	Membrane	IEA
GO:0021549	Process	Cerebellum development	IEA
GO:0021686	Process	Cerebellar granular layer maturation	IBA
GO:0021686	Process	Cerebellar granular layer maturation	IEA
GO:0021702	Process	Cerebellar Purkinje cell differentiation	IBA
GO:0021702	Process	Cerebellar Purkinje cell differentiation	IEA
GO:0021933	Process	Radial glia guided migration of cerebellar granule cell	IBA
GO:0021933	Process	Radial glia guided migration of cerebellar granule cell	IEA
GO:0021941	Process	Negative regulation of cerebellar granule cell precursor proliferation	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030182	Process	Neuron differentiation	IEA
GO:0031982	Component	Vesicle	IDA	11311134

Other IDs

• MIM: 608213
• HGNC: 24153
• e!Ensembl: ENSG00000184524

Protein

• UniProt ID: Q8N111
• Protein name: Cell cycle exit and neuronal differentiation protein 1 (BM88 antigen)
• Protein function: Involved in neuronal differentiation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15677	CEND1	1 → 149	Cell cycle exit and neuronal differentiation protein 1	Family

• Tissue specificity: TISSUE SPECIFICITY: Neuron specific. {ECO:0000269|PubMed:11311134}.
• Sequence:

  MESRGKSASSPKPDTKVPQVTTEAKVPPAADGKAPLTKPSKKEAPAEKQQPPAAPTTAPA
  KKTSAKADPALLNNHSNLKPAPTVPSSPDATPEPKGPGDGAEEDEAASGGPGGRGPWSCE
  NFNPLLVAGGVAVAAIALILGVAFLVRKK

• Sequence length: 149

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Familial cancer of breast	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Beckwith-Wiedemann Syndrome	Beckwith-Wiedemann Syndrome	BEFREE	11311134		★☆☆☆☆ Found in Text Mining only
Familial aplasia of the vermis	Cerebellar vermis agenesis	BEFREE	23658157		★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	BEFREE	23658157		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	11311134		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for CEND1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to CEND1.