CEACAM8 (CEA cell adhesion molecule 8)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 1088
• Gene name: CEA cell adhesion molecule 8
• Gene symbol: CEACAM8
• Synonyms (NCBI Gene): CD66b, CD67, CGM6, NCA-95
• Chromosome: 19
• Chromosome location: 19q13.2

miRNA Show/Hide all (269)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017848	hsa-miR-335-5p	Microarray	18185580
MIRT023291	hsa-miR-122-5p	Microarray	17612493
MIRT883124	hsa-miR-105	CLIP-seq
MIRT883125	hsa-miR-1179	CLIP-seq
MIRT883126	hsa-miR-1207-5p	CLIP-seq
MIRT883127	hsa-miR-1224-5p	CLIP-seq
MIRT883128	hsa-miR-1228	CLIP-seq
MIRT883129	hsa-miR-1254	CLIP-seq
MIRT883130	hsa-miR-1273	CLIP-seq
MIRT883131	hsa-miR-128	CLIP-seq
MIRT883132	hsa-miR-1304	CLIP-seq
MIRT883133	hsa-miR-140-3p	CLIP-seq
MIRT883134	hsa-miR-1827	CLIP-seq
MIRT883135	hsa-miR-2114	CLIP-seq
MIRT883136	hsa-miR-24	CLIP-seq
MIRT883137	hsa-miR-3116	CLIP-seq
MIRT883138	hsa-miR-3122	CLIP-seq
MIRT883139	hsa-miR-3174	CLIP-seq
MIRT883140	hsa-miR-342-3p	CLIP-seq
MIRT883141	hsa-miR-3613-3p	CLIP-seq
MIRT883142	hsa-miR-3650	CLIP-seq
MIRT883143	hsa-miR-3664-3p	CLIP-seq
MIRT883144	hsa-miR-3671	CLIP-seq
MIRT883145	hsa-miR-3672	CLIP-seq
MIRT883146	hsa-miR-3688-5p	CLIP-seq
MIRT883147	hsa-miR-3689a-3p	CLIP-seq
MIRT883148	hsa-miR-3689c	CLIP-seq
MIRT883149	hsa-miR-371-5p	CLIP-seq
MIRT883150	hsa-miR-371b-5p	CLIP-seq
MIRT883151	hsa-miR-3913-5p	CLIP-seq
MIRT883152	hsa-miR-3915	CLIP-seq
MIRT883153	hsa-miR-3928	CLIP-seq
MIRT883154	hsa-miR-3929	CLIP-seq
MIRT883155	hsa-miR-410	CLIP-seq
MIRT883156	hsa-miR-4284	CLIP-seq
MIRT883157	hsa-miR-4327	CLIP-seq
MIRT883158	hsa-miR-4419b	CLIP-seq
MIRT883159	hsa-miR-4433	CLIP-seq
MIRT883160	hsa-miR-4459	CLIP-seq
MIRT883161	hsa-miR-4461	CLIP-seq
MIRT883162	hsa-miR-4474-3p	CLIP-seq
MIRT883163	hsa-miR-4478	CLIP-seq
MIRT883164	hsa-miR-4649-3p	CLIP-seq
MIRT883165	hsa-miR-4689	CLIP-seq
MIRT883166	hsa-miR-4695-5p	CLIP-seq
MIRT883167	hsa-miR-4722-5p	CLIP-seq
MIRT883168	hsa-miR-4728-5p	CLIP-seq
MIRT883169	hsa-miR-4736	CLIP-seq
MIRT883170	hsa-miR-4742-3p	CLIP-seq
MIRT883171	hsa-miR-4763-3p	CLIP-seq
MIRT883172	hsa-miR-4768-3p	CLIP-seq
MIRT883173	hsa-miR-4786-5p	CLIP-seq
MIRT883174	hsa-miR-4790-3p	CLIP-seq
MIRT883175	hsa-miR-485-5p	CLIP-seq
MIRT883176	hsa-miR-510	CLIP-seq
MIRT883177	hsa-miR-512-5p	CLIP-seq
MIRT883178	hsa-miR-513c	CLIP-seq
MIRT883179	hsa-miR-514b-5p	CLIP-seq
MIRT883180	hsa-miR-548ac	CLIP-seq
MIRT883181	hsa-miR-548ae	CLIP-seq
MIRT883182	hsa-miR-548aj	CLIP-seq
MIRT883183	hsa-miR-548am	CLIP-seq
MIRT883184	hsa-miR-548d-3p	CLIP-seq
MIRT883185	hsa-miR-548x	CLIP-seq
MIRT883186	hsa-miR-548z	CLIP-seq
MIRT883187	hsa-miR-566	CLIP-seq
MIRT883188	hsa-miR-661	CLIP-seq
MIRT883189	hsa-miR-665	CLIP-seq
MIRT883190	hsa-miR-769-5p	CLIP-seq
MIRT883191	hsa-miR-940	CLIP-seq
MIRT883126	hsa-miR-1207-5p	CLIP-seq
MIRT883128	hsa-miR-1228	CLIP-seq
MIRT883130	hsa-miR-1273	CLIP-seq
MIRT883134	hsa-miR-1827	CLIP-seq
MIRT883135	hsa-miR-2114	CLIP-seq
MIRT883138	hsa-miR-3122	CLIP-seq
MIRT1961868	hsa-miR-3619-3p	CLIP-seq
MIRT883142	hsa-miR-3650	CLIP-seq
MIRT883143	hsa-miR-3664-3p	CLIP-seq
MIRT883146	hsa-miR-3688-5p	CLIP-seq
MIRT883147	hsa-miR-3689a-3p	CLIP-seq
MIRT883148	hsa-miR-3689c	CLIP-seq
MIRT883151	hsa-miR-3913-5p	CLIP-seq
MIRT883154	hsa-miR-3929	CLIP-seq
MIRT883158	hsa-miR-4419b	CLIP-seq
MIRT883159	hsa-miR-4433	CLIP-seq
MIRT883160	hsa-miR-4459	CLIP-seq
MIRT883162	hsa-miR-4474-3p	CLIP-seq
MIRT883163	hsa-miR-4478	CLIP-seq
MIRT1961869	hsa-miR-4486	CLIP-seq
MIRT1961870	hsa-miR-4528	CLIP-seq
MIRT883164	hsa-miR-4649-3p	CLIP-seq
MIRT1961871	hsa-miR-4649-5p	CLIP-seq
MIRT883166	hsa-miR-4695-5p	CLIP-seq
MIRT883167	hsa-miR-4722-5p	CLIP-seq
MIRT883168	hsa-miR-4728-5p	CLIP-seq
MIRT883169	hsa-miR-4736	CLIP-seq
MIRT883171	hsa-miR-4763-3p	CLIP-seq
MIRT883172	hsa-miR-4768-3p	CLIP-seq
MIRT883174	hsa-miR-4790-3p	CLIP-seq
MIRT1961872	hsa-miR-4795-3p	CLIP-seq
MIRT883175	hsa-miR-485-5p	CLIP-seq
MIRT883176	hsa-miR-510	CLIP-seq
MIRT883177	hsa-miR-512-5p	CLIP-seq
MIRT883180	hsa-miR-548ac	CLIP-seq
MIRT883181	hsa-miR-548ae	CLIP-seq
MIRT883182	hsa-miR-548aj	CLIP-seq
MIRT883183	hsa-miR-548am	CLIP-seq
MIRT883184	hsa-miR-548d-3p	CLIP-seq
MIRT883185	hsa-miR-548x	CLIP-seq
MIRT883186	hsa-miR-548z	CLIP-seq
MIRT883187	hsa-miR-566	CLIP-seq
MIRT1961873	hsa-miR-591	CLIP-seq
MIRT883188	hsa-miR-661	CLIP-seq
MIRT883189	hsa-miR-665	CLIP-seq
MIRT883191	hsa-miR-940	CLIP-seq
MIRT883126	hsa-miR-1207-5p	CLIP-seq
MIRT883128	hsa-miR-1228	CLIP-seq
MIRT883134	hsa-miR-1827	CLIP-seq
MIRT883135	hsa-miR-2114	CLIP-seq
MIRT2198424	hsa-miR-219-1-3p	CLIP-seq
MIRT883136	hsa-miR-24	CLIP-seq
MIRT883138	hsa-miR-3122	CLIP-seq
MIRT883139	hsa-miR-3174	CLIP-seq
MIRT2198425	hsa-miR-335	CLIP-seq
MIRT883140	hsa-miR-342-3p	CLIP-seq
MIRT2198426	hsa-miR-361-5p	CLIP-seq
MIRT1961868	hsa-miR-3619-3p	CLIP-seq
MIRT883142	hsa-miR-3650	CLIP-seq
MIRT883143	hsa-miR-3664-3p	CLIP-seq
MIRT883144	hsa-miR-3671	CLIP-seq
MIRT883146	hsa-miR-3688-5p	CLIP-seq
MIRT883147	hsa-miR-3689a-3p	CLIP-seq
MIRT883148	hsa-miR-3689c	CLIP-seq
MIRT883149	hsa-miR-371-5p	CLIP-seq
MIRT883150	hsa-miR-371b-5p	CLIP-seq
MIRT883151	hsa-miR-3913-5p	CLIP-seq
MIRT883154	hsa-miR-3929	CLIP-seq
MIRT2198427	hsa-miR-3937	CLIP-seq
MIRT883155	hsa-miR-410	CLIP-seq
MIRT883156	hsa-miR-4284	CLIP-seq
MIRT883157	hsa-miR-4327	CLIP-seq
MIRT883158	hsa-miR-4419b	CLIP-seq
MIRT883159	hsa-miR-4433	CLIP-seq
MIRT883160	hsa-miR-4459	CLIP-seq
MIRT883162	hsa-miR-4474-3p	CLIP-seq
MIRT883163	hsa-miR-4478	CLIP-seq
MIRT1961869	hsa-miR-4486	CLIP-seq
MIRT883164	hsa-miR-4649-3p	CLIP-seq
MIRT883166	hsa-miR-4695-5p	CLIP-seq
MIRT883167	hsa-miR-4722-5p	CLIP-seq
MIRT883168	hsa-miR-4728-5p	CLIP-seq
MIRT883169	hsa-miR-4736	CLIP-seq
MIRT883170	hsa-miR-4742-3p	CLIP-seq
MIRT883171	hsa-miR-4763-3p	CLIP-seq
MIRT883172	hsa-miR-4768-3p	CLIP-seq
MIRT883174	hsa-miR-4790-3p	CLIP-seq
MIRT883175	hsa-miR-485-5p	CLIP-seq
MIRT883176	hsa-miR-510	CLIP-seq
MIRT883177	hsa-miR-512-5p	CLIP-seq
MIRT883178	hsa-miR-513c	CLIP-seq
MIRT883179	hsa-miR-514b-5p	CLIP-seq
MIRT883187	hsa-miR-566	CLIP-seq
MIRT2198428	hsa-miR-571	CLIP-seq
MIRT2198429	hsa-miR-581	CLIP-seq
MIRT1961873	hsa-miR-591	CLIP-seq
MIRT883189	hsa-miR-665	CLIP-seq
MIRT2198430	hsa-miR-873	CLIP-seq
MIRT883191	hsa-miR-940	CLIP-seq
MIRT2198425	hsa-miR-335	CLIP-seq
MIRT2198426	hsa-miR-361-5p	CLIP-seq
MIRT883142	hsa-miR-3650	CLIP-seq
MIRT883160	hsa-miR-4459	CLIP-seq
MIRT883166	hsa-miR-4695-5p	CLIP-seq
MIRT883174	hsa-miR-4790-3p	CLIP-seq
MIRT2198429	hsa-miR-581	CLIP-seq
MIRT883189	hsa-miR-665	CLIP-seq
MIRT2198430	hsa-miR-873	CLIP-seq
MIRT883126	hsa-miR-1207-5p	CLIP-seq
MIRT883131	hsa-miR-128	CLIP-seq
MIRT883133	hsa-miR-140-3p	CLIP-seq
MIRT883141	hsa-miR-3613-3p	CLIP-seq
MIRT883146	hsa-miR-3688-5p	CLIP-seq
MIRT883162	hsa-miR-4474-3p	CLIP-seq
MIRT2446802	hsa-miR-4684-5p	CLIP-seq
MIRT883169	hsa-miR-4736	CLIP-seq
MIRT883171	hsa-miR-4763-3p	CLIP-seq
MIRT2446803	hsa-miR-548c-3p	CLIP-seq
MIRT883131	hsa-miR-128	CLIP-seq
MIRT883133	hsa-miR-140-3p	CLIP-seq
MIRT883141	hsa-miR-3613-3p	CLIP-seq
MIRT2446802	hsa-miR-4684-5p	CLIP-seq
MIRT2446803	hsa-miR-548c-3p	CLIP-seq
MIRT883126	hsa-miR-1207-5p	CLIP-seq
MIRT883128	hsa-miR-1228	CLIP-seq
MIRT883130	hsa-miR-1273	CLIP-seq
MIRT883131	hsa-miR-128	CLIP-seq
MIRT883133	hsa-miR-140-3p	CLIP-seq
MIRT883134	hsa-miR-1827	CLIP-seq
MIRT883138	hsa-miR-3122	CLIP-seq
MIRT883141	hsa-miR-3613-3p	CLIP-seq
MIRT883142	hsa-miR-3650	CLIP-seq
MIRT883146	hsa-miR-3688-5p	CLIP-seq
MIRT883147	hsa-miR-3689a-3p	CLIP-seq
MIRT883148	hsa-miR-3689c	CLIP-seq
MIRT883149	hsa-miR-371-5p	CLIP-seq
MIRT883150	hsa-miR-371b-5p	CLIP-seq
MIRT883151	hsa-miR-3913-5p	CLIP-seq
MIRT883154	hsa-miR-3929	CLIP-seq
MIRT2198427	hsa-miR-3937	CLIP-seq
MIRT2501464	hsa-miR-4252	CLIP-seq
MIRT883157	hsa-miR-4327	CLIP-seq
MIRT883158	hsa-miR-4419b	CLIP-seq
MIRT883160	hsa-miR-4459	CLIP-seq
MIRT883162	hsa-miR-4474-3p	CLIP-seq
MIRT883163	hsa-miR-4478	CLIP-seq
MIRT1961869	hsa-miR-4486	CLIP-seq
MIRT883164	hsa-miR-4649-3p	CLIP-seq
MIRT1961871	hsa-miR-4649-5p	CLIP-seq
MIRT2446802	hsa-miR-4684-5p	CLIP-seq
MIRT883166	hsa-miR-4695-5p	CLIP-seq
MIRT883167	hsa-miR-4722-5p	CLIP-seq
MIRT883168	hsa-miR-4728-5p	CLIP-seq
MIRT883169	hsa-miR-4736	CLIP-seq
MIRT883171	hsa-miR-4763-3p	CLIP-seq
MIRT883172	hsa-miR-4768-3p	CLIP-seq
MIRT883174	hsa-miR-4790-3p	CLIP-seq
MIRT2501465	hsa-miR-4793-3p	CLIP-seq
MIRT883175	hsa-miR-485-5p	CLIP-seq
MIRT2501466	hsa-miR-508-5p	CLIP-seq
MIRT2446803	hsa-miR-548c-3p	CLIP-seq
MIRT883187	hsa-miR-566	CLIP-seq
MIRT883188	hsa-miR-661	CLIP-seq
MIRT883189	hsa-miR-665	CLIP-seq
MIRT2501467	hsa-miR-766	CLIP-seq
MIRT883191	hsa-miR-940	CLIP-seq
MIRT883126	hsa-miR-1207-5p	CLIP-seq
MIRT883128	hsa-miR-1228	CLIP-seq
MIRT883130	hsa-miR-1273	CLIP-seq
MIRT883131	hsa-miR-128	CLIP-seq
MIRT883133	hsa-miR-140-3p	CLIP-seq
MIRT883134	hsa-miR-1827	CLIP-seq
MIRT883138	hsa-miR-3122	CLIP-seq
MIRT883141	hsa-miR-3613-3p	CLIP-seq
MIRT883146	hsa-miR-3688-5p	CLIP-seq
MIRT883147	hsa-miR-3689a-3p	CLIP-seq
MIRT883148	hsa-miR-3689c	CLIP-seq
MIRT883149	hsa-miR-371-5p	CLIP-seq
MIRT883150	hsa-miR-371b-5p	CLIP-seq
MIRT883151	hsa-miR-3913-5p	CLIP-seq
MIRT883154	hsa-miR-3929	CLIP-seq
MIRT2501464	hsa-miR-4252	CLIP-seq
MIRT883158	hsa-miR-4419b	CLIP-seq
MIRT883162	hsa-miR-4474-3p	CLIP-seq
MIRT883163	hsa-miR-4478	CLIP-seq
MIRT1961869	hsa-miR-4486	CLIP-seq
MIRT883164	hsa-miR-4649-3p	CLIP-seq
MIRT1961871	hsa-miR-4649-5p	CLIP-seq
MIRT2446802	hsa-miR-4684-5p	CLIP-seq
MIRT883168	hsa-miR-4728-5p	CLIP-seq
MIRT883169	hsa-miR-4736	CLIP-seq
MIRT883171	hsa-miR-4763-3p	CLIP-seq
MIRT2501465	hsa-miR-4793-3p	CLIP-seq
MIRT883175	hsa-miR-485-5p	CLIP-seq
MIRT2501466	hsa-miR-508-5p	CLIP-seq
MIRT2446803	hsa-miR-548c-3p	CLIP-seq
MIRT883188	hsa-miR-661	CLIP-seq
MIRT2501467	hsa-miR-766	CLIP-seq
MIRT883191	hsa-miR-940	CLIP-seq

Gene ontology (GO) Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	11994468, 21982860, 26483485
GO:0005615	Component	Extracellular space	IDA	25645918
GO:0005615	Component	Extracellular space	TAS	2306228
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	2306228
GO:0006955	Process	Immune response	TAS	2208113
GO:0007155	Process	Cell adhesion	IEA
GO:0007157	Process	Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA
GO:0007157	Process	Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IMP	8776764, 11590190
GO:0009986	Component	Cell surface	IBA
GO:0009986	Component	Cell surface	IDA	8776764
GO:0009986	Component	Cell surface	IEA
GO:0016020	Component	Membrane	IEA
GO:0035577	Component	Azurophil granule membrane	TAS
GO:0035579	Component	Specific granule membrane	TAS
GO:0046982	Function	Protein heterodimerization activity	IDA	26483485
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0070821	Component	Tertiary granule membrane	TAS
GO:0098552	Component	Side of membrane	IEA

Other IDs

• MIM: 615747
• HGNC: 1820
• e!Ensembl: ENSG00000124469

Protein

• UniProt ID: P31997
• Protein name: Cell adhesion molecule CEACAM8 (CD67 antigen) (Carcinoembryonic antigen CGM6) (Carcinoembryonic antigen-related cell adhesion molecule 8) (CEA cell adhesion molecule 8) (Non-specific cross-reacting antigen NCA-95) (CD antigen CD66b)
• Protein function: Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner (PubMed:11590190, PubMed:2022629, PubMed:8776764). Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecul
• PDB: 2DKS , 4WTZ , 4Y88 , 4YIQ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07686	V-set	39 → 141	Immunoglobulin V-set domain	Domain
  PF13895	Ig_2	239 → 318	Immunoglobulin domain	Domain
  PF13927	Ig_3	146 → 219		Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in leukocytes of chronic myeloid Leukemia patients and bone marrow.
• Sequence:

  MGPISAPSCRWRIPWQGLLLTASLFTFWNPPTTAQLTIEAVPSNAAEGKEVLLLVHNLPQ
  DPRGYNWYKGETVDANRRIIGYVISNQQITPGPAYSNRETIYPNASLLMRNVTRNDTGSY
  TLQVIKLNLMSEEVTGQFSVHPETPKPSISSNNSNPVEDKDAVAFTCEPETQNTTYLWWV
  NGQSLPVSPRLQLSNGNRTLTLLSVTRNDVGPYECEIQNPASANFSDPVTLNVLYGPDAP
  TISPSDTYYHAGVNLNLSCHAASNPPSQYSWSVNGTFQQYTQKLFIPNITTKNSGSYACH
  TTNSATGRNRTTVRMITVSDALVQGSSPGLSARATVSIMIGVLARVALI

• Sequence length: 349

Pathways

Reactome Pathway

Fibronectin matrix formation

Cell surface interactions at the vascular wall

Neutrophil degranulation

Related Genes

Sort by: Blended Diseases Pathways Evidence source

CEACAM6 2 shared pathwaysCell surface interactions at the vascular wall, Fibronectin matrix formation Related via 2 shared pathways including Cell surface interactions at the vascular wall, Fibronectin matrix formation. CEACAM1 2 shared pathwaysCell surface interactions at the vascular wall, Fibronectin matrix formation Related via 2 shared pathways including Cell surface interactions at the vascular wall, Fibronectin matrix formation. ITGA5 2 shared pathwaysCell surface interactions at the vascular wall, Fibronectin matrix formation Related via 2 shared pathways including Cell surface interactions at the vascular wall, Fibronectin matrix formation. FN1 2 shared pathwaysCell surface interactions at the vascular wall, Fibronectin matrix formation Related via 2 shared pathways including Cell surface interactions at the vascular wall, Fibronectin matrix formation. ITGB1 2 shared pathwaysCell surface interactions at the vascular wall, Fibronectin matrix formation Related via 2 shared pathways including Cell surface interactions at the vascular wall, Fibronectin matrix formation.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
CEACAM6	0	[]	2	["Cell surface interactions at the vascular wall","Fibronectin matrix formation"]	0	[]
CEACAM1	0	[]	2	["Cell surface interactions at the vascular wall","Fibronectin matrix formation"]	0	[]
ITGA5	0	[]	2	["Cell surface interactions at the vascular wall","Fibronectin matrix formation"]	0	[]
FN1	0	[]	2	["Cell surface interactions at the vascular wall","Fibronectin matrix formation"]	0	[]
ITGB1	0	[]	2	["Cell surface interactions at the vascular wall","Fibronectin matrix formation"]	0	[]

Diseases Linked via Similar Genes

Squamous cell carcinoma Linked via 2 of 5 related genesITGA5, ITGB1 Endometriosis Linked via 2 of 5 related genesFN1, ITGB1 Astrocytoma Linked via 1 of 5 related genesCEACAM6 Cystic fibrosis Linked via 1 of 5 related genesCEACAM6 Parkinson disease Linked via 1 of 5 related genesCEACAM6

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Squamous cell carcinoma	2	["ITGA5","ITGB1"]
Endometriosis	2	["FN1","ITGB1"]
Astrocytoma	1	["CEACAM6"]
Cystic fibrosis	1	["CEACAM6"]
Parkinson disease	1	["CEACAM6"]