CDNF (cerebral dopamine neurotrophic factor)

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Gene miRNA Gene ontology Other IDs Protein Diseases linked via similar genes

Gene

• Entrez ID: 441549
• Gene name: Cerebral dopamine neurotrophic factor
• Gene symbol: CDNF
• Synonyms (NCBI Gene): ARMETL1
• Chromosome: 10
• Chromosome location: 10p13

miRNA Show/Hide all (58)

miRTarBase ID	miRNA	Experiments	Reference
MIRT682859	hsa-miR-1273g-3p	HITS-CLIP	23706177
MIRT682858	hsa-miR-4252	HITS-CLIP	23706177
MIRT682857	hsa-miR-3926	HITS-CLIP	23706177
MIRT682856	hsa-miR-6807-5p	HITS-CLIP	23706177
MIRT637113	hsa-miR-4999-3p	HITS-CLIP	23824327
MIRT637112	hsa-miR-1207-5p	HITS-CLIP	23824327
MIRT637111	hsa-miR-4763-3p	HITS-CLIP	23824327
MIRT637110	hsa-miR-4736	HITS-CLIP	23824327
MIRT637109	hsa-miR-7150	HITS-CLIP	23824327
MIRT631429	hsa-miR-614	HITS-CLIP	23824327
MIRT631428	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT631427	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT631426	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT631425	hsa-miR-4532	HITS-CLIP	23824327
MIRT631424	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT631423	hsa-miR-1281	HITS-CLIP	23824327
MIRT631422	hsa-miR-125b-1-3p	HITS-CLIP	23824327
MIRT631421	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT631420	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT631419	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT631418	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT682859	hsa-miR-1273g-3p	HITS-CLIP	23706177
MIRT682858	hsa-miR-4252	HITS-CLIP	23706177
MIRT682857	hsa-miR-3926	HITS-CLIP	23706177
MIRT682856	hsa-miR-6807-5p	HITS-CLIP	23706177
MIRT637113	hsa-miR-4999-3p	HITS-CLIP	23824327
MIRT637112	hsa-miR-1207-5p	HITS-CLIP	23824327
MIRT637111	hsa-miR-4763-3p	HITS-CLIP	23824327
MIRT637110	hsa-miR-4736	HITS-CLIP	23824327
MIRT637109	hsa-miR-7150	HITS-CLIP	23824327
MIRT631429	hsa-miR-614	HITS-CLIP	23824327
MIRT631428	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT631427	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT631426	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT631425	hsa-miR-4532	HITS-CLIP	23824327
MIRT631424	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT631423	hsa-miR-1281	HITS-CLIP	23824327
MIRT631422	hsa-miR-125b-1-3p	HITS-CLIP	23824327
MIRT631421	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT631420	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT631419	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT631418	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT881914	hsa-miR-3153	CLIP-seq
MIRT881915	hsa-miR-362-5p	CLIP-seq
MIRT881916	hsa-miR-4659a-3p	CLIP-seq
MIRT881917	hsa-miR-4659b-3p	CLIP-seq
MIRT881918	hsa-miR-4668-5p	CLIP-seq
MIRT881919	hsa-miR-4712-3p	CLIP-seq
MIRT881920	hsa-miR-500b	CLIP-seq
MIRT881921	hsa-miR-501-5p	CLIP-seq
MIRT881922	hsa-miR-539	CLIP-seq
MIRT881923	hsa-miR-629	CLIP-seq
MIRT881916	hsa-miR-4659a-3p	CLIP-seq
MIRT881917	hsa-miR-4659b-3p	CLIP-seq
MIRT881923	hsa-miR-629	CLIP-seq
MIRT2385877	hsa-miR-3145-5p	CLIP-seq
MIRT2385878	hsa-miR-4699-3p	CLIP-seq
MIRT2385879	hsa-miR-508-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (7)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0007165	Process	Signal transduction	IEA
GO:0008083	Function	Growth factor activity	IEA
GO:0031175	Process	Neuron projection development	IBA
GO:0071542	Process	Dopaminergic neuron differentiation	IBA

Other IDs

• MIM: 611233
• HGNC: 24913
• e!Ensembl: ENSG00000185267

Protein

• UniProt ID: Q49AH0
• Protein name: Cerebral dopamine neurotrophic factor (ARMET-like protein 1) (Conserved dopamine neurotrophic factor)
• Protein function: Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic
• PDB: 2LPN , 2W50 , 4BIT , 8QAJ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10208	Armet	36 → 181	Degradation arginine-rich protein for mis-folding	Family

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed in neuronal and non-neuronal tissues. In the brain, highest levels in the optic nerve and corpus callosum. {ECO:0000269|PubMed:17611540}.
• Sequence:

  MWCASPVAVVAFCAGLLVSHPVLTQGQEAGGRPGADCEVCKEFLNRFYKSLIDRGVNFSL
  DTIEKELISFCLDTKGKENRLCYYLGATKDAATKILSEVTRPMSVHMPAMKICEKLKKLD
  SQICELKYEKTLDLASVDLRKMRVAELKQILHSWGEECRACAEKTDYVNLIQELAPKYAA
  THPKTEL

• Sequence length: 187

Related Genes

No strongly related genes found yet for CDNF.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to CDNF.