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Gene Gene information from NCBI Gene database.
Entrez ID 10423
Gene name CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Gene symbol CDIPT
Synonyms (NCBI Gene)
PISPIS1
Chromosome 16
Chromosome location 16p11.2
Summary Phosphatidylinositol breakdown products are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. Two enzymes, CDP-diacylgl
miRNA miRNA information provided by mirtarbase database.
445 Show/Hide all (445)
miRTarBase ID miRNA Experiments Reference
MIRT001644 hsa-let-7b-5p pSILAC 18668040
MIRT029083 hsa-miR-26b-5p Microarray 19088304
MIRT031548 hsa-miR-16-5p Proteomics 18668040
MIRT001644 hsa-let-7b-5p Proteomics;Other 18668040
MIRT043315 hsa-miR-331-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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GO ID Ontology Definition Evidence Reference
GO:0003881 Function CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity IBA
GO:0003881 Function CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity IDA 8110188, 9407135
GO:0003881 Function CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity IEA
GO:0005515 Function Protein binding IPI 25416956, 32296183
GO:0005783 Component Endoplasmic reticulum IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605893 1769 ENSG00000103502
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O14735
Protein name CDP-diacylglycerol--inositol 3-phosphatidyltransferase (EC 2.7.8.11) (Phosphatidylinositol synthase) (PI synthase) (PtdIns synthase)
Protein function Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01066 CDP-OH_P_transf 9 → 72 CDP-alcohol phosphatidyltransferase Family
Tissue specificity TISSUE SPECIFICITY: Detected in placenta (at protein level). Widely expressed. Higher expression in adult liver and skeletal muscle, slightly lower levels seen in pancreas, kidney, lung, placenta, brain, heart, leukocyte, colon, small intestine, ovary, te
Sequence
MPDENIFLFVPNLIGYARIVFAIISFYFMPCCPLTASSFYLLSGLLDAFDGHAARALNQG
TRFGAMLDMLTD
RCSTMCLLVNLALLYPGATLFFQISMSLDVASHWLHLHSSVVRGSESH
KMIDLSGNPVLRIYYTSRPALFTLCAGNELFYCLLYLFHFSEGPLVGSVGLFRMGLWVTA
PIALLKSLISVIHLITAARNMAALDAADRAKKK
Sequence length 213
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Inositol phosphate metabolism Synthesis of PI
Glycerophospholipid metabolism  
Metabolic pathways  
Phosphatidylinositol signaling system