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Gene Gene information from NCBI Gene database.
Entrez ID 23580
Gene name CDC42 effector protein 4
Gene symbol CDC42EP4
Synonyms (NCBI Gene)
BORG4CEP4KAIA1777
Chromosome 17
Chromosome location 17q25.1
Summary The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a
miRNA miRNA information provided by mirtarbase database.
439 Show/Hide all (439)
miRTarBase ID miRNA Experiments Reference
MIRT016422 hsa-miR-193b-3p Microarray 20304954
MIRT017707 hsa-miR-335-5p Microarray 18185580
MIRT025742 hsa-miR-7-5p Microarray 19073608
MIRT036563 hsa-miR-941 CLASH 23622248
MIRT036315 hsa-miR-1229-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
26 Show/Hide all (26)
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674
GO:0005515 Function Protein binding IPI 25416956, 31515488, 32814053
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IEA
GO:0005829 Component Cytosol TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605468 17147 ENSG00000179604
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9H3Q1
Protein name Cdc42 effector protein 4 (Binder of Rho GTPases 4)
Protein function Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00786 PBD 26 → 85 P21-Rho-binding domain Domain
PF14957 BORG_CEP 112 → 228 Cdc42 effector Family
Tissue specificity TISSUE SPECIFICITY: Not detected in any of the adult tissues tested. May be expressed only in fetal or embryonic tissues.
Sequence
MPILKQLVSSSVHSKRRSRADLTAEMISAPLGDFRHTMHVGRAGDAFGDTSFLNSKAGEP
DGESLDEQPSSSSSKRSLLSRKFRG
SKRSQSVTRGEREQRDMLGSLRDSALFVKNAMSLP
QLNEKEAAEKGTSKLPKSLSSSPVKKANDGEGGDEEAGTEEAVPRRNGAAGPHSPDPLLD
EQAFGDLTDLPVVPKATYGLKHAESIMSFHIDLGPSMLGDVLSIMDKE
EWDPEEGEGGYH
GDEGAAGTITQAPPYAVAAPPLARQEGKAGPDLPSLPSHALEDEGWAAAAPSPGSARSMG
SHTTRDSSSLSSCTSGILEERSPAFRGPDRARAAVSRQPDKEFSFMDEEEEDEIRV
Sequence length 356
Interactions View interactions