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Gene Gene information from NCBI Gene database.
Entrez ID 3732
Gene name CD82 molecule
Gene symbol CD82
Synonyms (NCBI Gene)
4F9C33GR15IA4KAI1R2SAR2ST6TSPAN27
Chromosome 11
Chromosome location 11p11.2
Summary This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a
miRNA miRNA information provided by mirtarbase database.
188 Show/Hide all (188)
miRTarBase ID miRNA Experiments Reference
MIRT054277 hsa-miR-362-3p Luciferase reporter assayqRT-PCRWestern blot 25652145
MIRT054277 hsa-miR-362-3p Luciferase reporter assayqRT-PCRWestern blot 25652145
MIRT054634 hsa-miR-197-3p ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot 24613834
MIRT054634 hsa-miR-197-3p ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot 24613834
MIRT650687 hsa-miR-130b-5p HITS-CLIP 23824327
Transcription factors Transcription factors information provided by TRRUST V2 database.
6 Show/Hide all (6)
Transcription factor Regulation Reference
ATF3 Unknown 21454613
HDAC1 Repression 19182791
JUN Activation 15580298
JUNB Activation 15580298
TFAP2A Activation 15580298
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
9 Show/Hide all (9)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 15205336, 28030805, 32296183
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IDA 30463011
GO:0005886 Component Plasma membrane IEA
GO:0005886 Component Plasma membrane TAS 1842498, 7754374
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600623 6210 ENSG00000085117
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P27701
Protein name CD82 antigen (C33 antigen) (IA4) (Inducible membrane protein R2) (Metastasis suppressor Kangai-1) (Suppressor of tumorigenicity 6 protein) (Tetraspanin-27) (Tspan-27) (CD antigen CD82)
Protein function Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling (PubMed:19497983). Participates thereby in diverse biological functions su
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00335 Tetraspanin 9 → 255 Tetraspanin family Family
Tissue specificity TISSUE SPECIFICITY: Lymphoid specific.
Sequence
Sequence length 267
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway
p53 signaling pathway
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
7
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Show/Hide Unknown Diseases (7)
Phenotype Name Clinical Significance Source Reference Evidence Score
Acute myeloid leukemia Benign ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Cervical cancer Benign ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney Benign ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Lung cancer Benign ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma Benign ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (158)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 29113211
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 8620488
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 10551326, 25912735
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of pancreas Pancreatic adenocarcinoma BEFREE 18286698
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 10582691
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenomatous Polyposis Coli Multiple polyposis syndrome BEFREE 15014022
★★★★★
★☆☆☆☆
Found in Text Mining only
Adult Acute Lymphocytic Leukemia Lymphocytic Leukemia BEFREE 29113211
★★★★★
★☆☆☆☆
Found in Text Mining only
Adult Hepatocellular Carcinoma Liver carcinoma BEFREE 9828210
★★★★★
★☆☆☆☆
Found in Text Mining only
Anaplastic thyroid carcinoma Anaplastic thyroid cancer BEFREE 15375577
★★★★★
★☆☆☆☆
Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA Syndromic microphthalmia BEFREE 28030805
★★★★★
★☆☆☆☆
Found in Text Mining only