CD2BP2 (CD2 cytoplasmic tail binding protein 2)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 10421
• Gene name: CD2 cytoplasmic tail binding protein 2
• Gene symbol: CD2BP2
• Synonyms (NCBI Gene): FWP010, LIN1, PPP1R59, Snu40, U5-52K
• Chromosome: 16
• Chromosome location: 16p11.2
• Summary: This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a c

miRNA Show/Hide all (306)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022522	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT051962	hsa-let-7b-5p	CLASH	23622248
MIRT049524	hsa-miR-92a-3p	CLASH	23622248
MIRT042172	hsa-miR-484	CLASH	23622248
MIRT039811	hsa-miR-615-3p	CLASH	23622248
MIRT052875	hsa-miR-3679-3p	CLASH	23622248
MIRT874795	hsa-miR-1238	CLIP-seq
MIRT874796	hsa-miR-125a-3p	CLIP-seq
MIRT874797	hsa-miR-1275	CLIP-seq
MIRT874798	hsa-miR-1289	CLIP-seq
MIRT874799	hsa-miR-1292	CLIP-seq
MIRT874800	hsa-miR-1825	CLIP-seq
MIRT874801	hsa-miR-1914	CLIP-seq
MIRT874802	hsa-miR-199a-5p	CLIP-seq
MIRT874803	hsa-miR-199b-5p	CLIP-seq
MIRT874804	hsa-miR-3119	CLIP-seq
MIRT874805	hsa-miR-3153	CLIP-seq
MIRT874806	hsa-miR-3168	CLIP-seq
MIRT874807	hsa-miR-3174	CLIP-seq
MIRT874808	hsa-miR-3179	CLIP-seq
MIRT874809	hsa-miR-3614-5p	CLIP-seq
MIRT874810	hsa-miR-3925-3p	CLIP-seq
MIRT874811	hsa-miR-3934	CLIP-seq
MIRT874812	hsa-miR-4259	CLIP-seq
MIRT874813	hsa-miR-4277	CLIP-seq
MIRT874814	hsa-miR-4286	CLIP-seq
MIRT874815	hsa-miR-4318	CLIP-seq
MIRT874816	hsa-miR-4324	CLIP-seq
MIRT874817	hsa-miR-4325	CLIP-seq
MIRT874818	hsa-miR-4329	CLIP-seq
MIRT874819	hsa-miR-4420	CLIP-seq
MIRT874820	hsa-miR-4433	CLIP-seq
MIRT874821	hsa-miR-4446-3p	CLIP-seq
MIRT874822	hsa-miR-4457	CLIP-seq
MIRT874823	hsa-miR-4459	CLIP-seq
MIRT874824	hsa-miR-4471	CLIP-seq
MIRT874825	hsa-miR-4648	CLIP-seq
MIRT874826	hsa-miR-4650-5p	CLIP-seq
MIRT874827	hsa-miR-4654	CLIP-seq
MIRT874828	hsa-miR-4665-5p	CLIP-seq
MIRT874829	hsa-miR-4668-5p	CLIP-seq
MIRT874830	hsa-miR-4675	CLIP-seq
MIRT874831	hsa-miR-4679	CLIP-seq
MIRT874832	hsa-miR-4693-5p	CLIP-seq
MIRT874833	hsa-miR-4695-3p	CLIP-seq
MIRT874834	hsa-miR-4698	CLIP-seq
MIRT874835	hsa-miR-4741	CLIP-seq
MIRT874836	hsa-miR-4757-5p	CLIP-seq
MIRT874837	hsa-miR-4768-3p	CLIP-seq
MIRT874838	hsa-miR-4769-5p	CLIP-seq
MIRT874839	hsa-miR-4777-5p	CLIP-seq
MIRT874840	hsa-miR-4778-3p	CLIP-seq
MIRT874841	hsa-miR-503	CLIP-seq
MIRT874842	hsa-miR-507	CLIP-seq
MIRT874843	hsa-miR-513b	CLIP-seq
MIRT874844	hsa-miR-518d-5p	CLIP-seq
MIRT874845	hsa-miR-519b-5p	CLIP-seq
MIRT874846	hsa-miR-519c-5p	CLIP-seq
MIRT874847	hsa-miR-520c-5p	CLIP-seq
MIRT874848	hsa-miR-522	CLIP-seq
MIRT874849	hsa-miR-526a	CLIP-seq
MIRT874850	hsa-miR-548al	CLIP-seq
MIRT874851	hsa-miR-557	CLIP-seq
MIRT874852	hsa-miR-582-5p	CLIP-seq
MIRT874853	hsa-miR-592	CLIP-seq
MIRT874854	hsa-miR-597	CLIP-seq
MIRT874855	hsa-miR-600	CLIP-seq
MIRT874856	hsa-miR-602	CLIP-seq
MIRT874857	hsa-miR-609	CLIP-seq
MIRT874858	hsa-miR-639	CLIP-seq
MIRT874859	hsa-miR-665	CLIP-seq
MIRT874860	hsa-miR-720	CLIP-seq
MIRT874861	hsa-miR-764	CLIP-seq
MIRT874862	hsa-miR-766	CLIP-seq
MIRT874863	hsa-miR-892a	CLIP-seq
MIRT874797	hsa-miR-1275	CLIP-seq
MIRT874798	hsa-miR-1289	CLIP-seq
MIRT1959367	hsa-miR-2467-5p	CLIP-seq
MIRT874804	hsa-miR-3119	CLIP-seq
MIRT874805	hsa-miR-3153	CLIP-seq
MIRT1959368	hsa-miR-3154	CLIP-seq
MIRT874806	hsa-miR-3168	CLIP-seq
MIRT874808	hsa-miR-3179	CLIP-seq
MIRT1959369	hsa-miR-3187-3p	CLIP-seq
MIRT1959370	hsa-miR-326	CLIP-seq
MIRT1959371	hsa-miR-330-5p	CLIP-seq
MIRT874809	hsa-miR-3614-5p	CLIP-seq
MIRT1959372	hsa-miR-4252	CLIP-seq
MIRT874812	hsa-miR-4259	CLIP-seq
MIRT874813	hsa-miR-4277	CLIP-seq
MIRT1959373	hsa-miR-4311	CLIP-seq
MIRT874816	hsa-miR-4324	CLIP-seq
MIRT874817	hsa-miR-4325	CLIP-seq
MIRT874818	hsa-miR-4329	CLIP-seq
MIRT874819	hsa-miR-4420	CLIP-seq
MIRT874820	hsa-miR-4433	CLIP-seq
MIRT1959374	hsa-miR-4435	CLIP-seq
MIRT874821	hsa-miR-4446-3p	CLIP-seq
MIRT874823	hsa-miR-4459	CLIP-seq
MIRT1959375	hsa-miR-4484	CLIP-seq
MIRT1959376	hsa-miR-4509	CLIP-seq
MIRT874825	hsa-miR-4648	CLIP-seq
MIRT874827	hsa-miR-4654	CLIP-seq
MIRT874828	hsa-miR-4665-5p	CLIP-seq
MIRT1959377	hsa-miR-4667-5p	CLIP-seq
MIRT874829	hsa-miR-4668-5p	CLIP-seq
MIRT874830	hsa-miR-4675	CLIP-seq
MIRT1959378	hsa-miR-4680-3p	CLIP-seq
MIRT1959379	hsa-miR-4682	CLIP-seq
MIRT1959380	hsa-miR-4691-5p	CLIP-seq
MIRT1959381	hsa-miR-4700-5p	CLIP-seq
MIRT1959382	hsa-miR-4701-5p	CLIP-seq
MIRT874835	hsa-miR-4741	CLIP-seq
MIRT1959383	hsa-miR-4749-3p	CLIP-seq
MIRT874836	hsa-miR-4757-5p	CLIP-seq
MIRT874837	hsa-miR-4768-3p	CLIP-seq
MIRT874838	hsa-miR-4769-5p	CLIP-seq
MIRT874839	hsa-miR-4777-5p	CLIP-seq
MIRT1959384	hsa-miR-486-3p	CLIP-seq
MIRT1959385	hsa-miR-502-5p	CLIP-seq
MIRT874842	hsa-miR-507	CLIP-seq
MIRT1959386	hsa-miR-510	CLIP-seq
MIRT1959387	hsa-miR-512-5p	CLIP-seq
MIRT1959388	hsa-miR-515-5p	CLIP-seq
MIRT1959389	hsa-miR-516a-3p	CLIP-seq
MIRT874844	hsa-miR-518d-5p	CLIP-seq
MIRT874845	hsa-miR-519b-5p	CLIP-seq
MIRT874846	hsa-miR-519c-5p	CLIP-seq
MIRT874847	hsa-miR-520c-5p	CLIP-seq
MIRT874849	hsa-miR-526a	CLIP-seq
MIRT874850	hsa-miR-548al	CLIP-seq
MIRT1959390	hsa-miR-548an	CLIP-seq
MIRT1959391	hsa-miR-548s	CLIP-seq
MIRT1959392	hsa-miR-550a	CLIP-seq
MIRT874851	hsa-miR-557	CLIP-seq
MIRT1959393	hsa-miR-588	CLIP-seq
MIRT874856	hsa-miR-602	CLIP-seq
MIRT874857	hsa-miR-609	CLIP-seq
MIRT1959394	hsa-miR-637	CLIP-seq
MIRT874859	hsa-miR-665	CLIP-seq
MIRT1959395	hsa-miR-760	CLIP-seq
MIRT2196360	hsa-miR-1207-5p	CLIP-seq
MIRT2196361	hsa-miR-1226	CLIP-seq
MIRT874797	hsa-miR-1275	CLIP-seq
MIRT874798	hsa-miR-1289	CLIP-seq
MIRT2196362	hsa-miR-130a	CLIP-seq
MIRT2196363	hsa-miR-130b	CLIP-seq
MIRT2196364	hsa-miR-1321	CLIP-seq
MIRT2196365	hsa-miR-197	CLIP-seq
MIRT2196366	hsa-miR-19a	CLIP-seq
MIRT2196367	hsa-miR-19b	CLIP-seq
MIRT2196368	hsa-miR-2355-5p	CLIP-seq
MIRT2196369	hsa-miR-301a	CLIP-seq
MIRT2196370	hsa-miR-301b	CLIP-seq
MIRT2196371	hsa-miR-3145-5p	CLIP-seq
MIRT874806	hsa-miR-3168	CLIP-seq
MIRT874809	hsa-miR-3614-5p	CLIP-seq
MIRT2196372	hsa-miR-3666	CLIP-seq
MIRT2196373	hsa-miR-3929	CLIP-seq
MIRT874812	hsa-miR-4259	CLIP-seq
MIRT2196374	hsa-miR-4270	CLIP-seq
MIRT874813	hsa-miR-4277	CLIP-seq
MIRT874814	hsa-miR-4286	CLIP-seq
MIRT2196375	hsa-miR-4295	CLIP-seq
MIRT2196376	hsa-miR-4419b	CLIP-seq
MIRT874820	hsa-miR-4433	CLIP-seq
MIRT2196377	hsa-miR-4441	CLIP-seq
MIRT874823	hsa-miR-4459	CLIP-seq
MIRT2196378	hsa-miR-4478	CLIP-seq
MIRT2196379	hsa-miR-4514	CLIP-seq
MIRT2196380	hsa-miR-454	CLIP-seq
MIRT2196381	hsa-miR-4645-5p	CLIP-seq
MIRT874828	hsa-miR-4665-5p	CLIP-seq
MIRT2196382	hsa-miR-4673	CLIP-seq
MIRT1959378	hsa-miR-4680-3p	CLIP-seq
MIRT2196383	hsa-miR-4688	CLIP-seq
MIRT1959380	hsa-miR-4691-5p	CLIP-seq
MIRT2196384	hsa-miR-4692	CLIP-seq
MIRT874834	hsa-miR-4698	CLIP-seq
MIRT2196385	hsa-miR-4717-5p	CLIP-seq
MIRT2196386	hsa-miR-4733-3p	CLIP-seq
MIRT2196387	hsa-miR-4739	CLIP-seq
MIRT2196388	hsa-miR-4756-5p	CLIP-seq
MIRT874836	hsa-miR-4757-5p	CLIP-seq
MIRT2196389	hsa-miR-4763-3p	CLIP-seq
MIRT874837	hsa-miR-4768-3p	CLIP-seq
MIRT874839	hsa-miR-4777-5p	CLIP-seq
MIRT2196390	hsa-miR-4795-3p	CLIP-seq
MIRT1959384	hsa-miR-486-3p	CLIP-seq
MIRT2196391	hsa-miR-5096	CLIP-seq
MIRT874844	hsa-miR-518d-5p	CLIP-seq
MIRT874845	hsa-miR-519b-5p	CLIP-seq
MIRT874846	hsa-miR-519c-5p	CLIP-seq
MIRT874847	hsa-miR-520c-5p	CLIP-seq
MIRT874848	hsa-miR-522	CLIP-seq
MIRT874849	hsa-miR-526a	CLIP-seq
MIRT874850	hsa-miR-548al	CLIP-seq
MIRT1959392	hsa-miR-550a	CLIP-seq
MIRT874852	hsa-miR-582-5p	CLIP-seq
MIRT874855	hsa-miR-600	CLIP-seq
MIRT874856	hsa-miR-602	CLIP-seq
MIRT874857	hsa-miR-609	CLIP-seq
MIRT874859	hsa-miR-665	CLIP-seq
MIRT2196392	hsa-miR-759	CLIP-seq
MIRT2196393	hsa-miR-940	CLIP-seq
MIRT874797	hsa-miR-1275	CLIP-seq
MIRT874806	hsa-miR-3168	CLIP-seq
MIRT1959369	hsa-miR-3187-3p	CLIP-seq
MIRT874812	hsa-miR-4259	CLIP-seq
MIRT874813	hsa-miR-4277	CLIP-seq
MIRT874828	hsa-miR-4665-5p	CLIP-seq
MIRT874839	hsa-miR-4777-5p	CLIP-seq
MIRT874844	hsa-miR-518d-5p	CLIP-seq
MIRT874845	hsa-miR-519b-5p	CLIP-seq
MIRT874846	hsa-miR-519c-5p	CLIP-seq
MIRT874847	hsa-miR-520c-5p	CLIP-seq
MIRT874849	hsa-miR-526a	CLIP-seq
MIRT874850	hsa-miR-548al	CLIP-seq
MIRT2385733	hsa-miR-570	CLIP-seq
MIRT874852	hsa-miR-582-5p	CLIP-seq
MIRT874856	hsa-miR-602	CLIP-seq
MIRT874857	hsa-miR-609	CLIP-seq
MIRT1959394	hsa-miR-637	CLIP-seq
MIRT874795	hsa-miR-1238	CLIP-seq
MIRT2499334	hsa-miR-1254	CLIP-seq
MIRT2499335	hsa-miR-28-5p	CLIP-seq
MIRT2499336	hsa-miR-296-5p	CLIP-seq
MIRT2499337	hsa-miR-3116	CLIP-seq
MIRT874804	hsa-miR-3119	CLIP-seq
MIRT2499338	hsa-miR-3139	CLIP-seq
MIRT874805	hsa-miR-3153	CLIP-seq
MIRT1959368	hsa-miR-3154	CLIP-seq
MIRT2499339	hsa-miR-3160-5p	CLIP-seq
MIRT2499340	hsa-miR-3173-3p	CLIP-seq
MIRT874809	hsa-miR-3614-5p	CLIP-seq
MIRT2499341	hsa-miR-365	CLIP-seq
MIRT2499342	hsa-miR-3687	CLIP-seq
MIRT2499343	hsa-miR-3692	CLIP-seq
MIRT874816	hsa-miR-4324	CLIP-seq
MIRT874818	hsa-miR-4329	CLIP-seq
MIRT2499344	hsa-miR-4428	CLIP-seq
MIRT2499345	hsa-miR-4436b-5p	CLIP-seq
MIRT2499346	hsa-miR-4442	CLIP-seq
MIRT1959375	hsa-miR-4484	CLIP-seq
MIRT1959376	hsa-miR-4509	CLIP-seq
MIRT2499347	hsa-miR-4521	CLIP-seq
MIRT2499348	hsa-miR-4640-5p	CLIP-seq
MIRT874829	hsa-miR-4668-5p	CLIP-seq
MIRT1959380	hsa-miR-4691-5p	CLIP-seq
MIRT874834	hsa-miR-4698	CLIP-seq
MIRT2499349	hsa-miR-4726-5p	CLIP-seq
MIRT874836	hsa-miR-4757-5p	CLIP-seq
MIRT1959390	hsa-miR-548an	CLIP-seq
MIRT874858	hsa-miR-639	CLIP-seq
MIRT2499350	hsa-miR-661	CLIP-seq
MIRT874859	hsa-miR-665	CLIP-seq
MIRT2499351	hsa-miR-708	CLIP-seq
MIRT874860	hsa-miR-720	CLIP-seq
MIRT2677664	hsa-miR-1237	CLIP-seq
MIRT874795	hsa-miR-1238	CLIP-seq
MIRT2677665	hsa-miR-1248	CLIP-seq
MIRT2499334	hsa-miR-1254	CLIP-seq
MIRT2677666	hsa-miR-1266	CLIP-seq
MIRT2677667	hsa-miR-1285	CLIP-seq
MIRT2677668	hsa-miR-146b-3p	CLIP-seq
MIRT2677669	hsa-miR-2861	CLIP-seq
MIRT2499336	hsa-miR-296-5p	CLIP-seq
MIRT2499337	hsa-miR-3116	CLIP-seq
MIRT874804	hsa-miR-3119	CLIP-seq
MIRT874805	hsa-miR-3153	CLIP-seq
MIRT1959368	hsa-miR-3154	CLIP-seq
MIRT2499339	hsa-miR-3160-5p	CLIP-seq
MIRT2677670	hsa-miR-3173-5p	CLIP-seq
MIRT2677671	hsa-miR-3187-5p	CLIP-seq
MIRT2677672	hsa-miR-361-3p	CLIP-seq
MIRT874809	hsa-miR-3614-5p	CLIP-seq
MIRT2499341	hsa-miR-365	CLIP-seq
MIRT2499342	hsa-miR-3687	CLIP-seq
MIRT2499343	hsa-miR-3692	CLIP-seq
MIRT2677673	hsa-miR-378g	CLIP-seq
MIRT2677674	hsa-miR-4314	CLIP-seq
MIRT874816	hsa-miR-4324	CLIP-seq
MIRT874818	hsa-miR-4329	CLIP-seq
MIRT2499345	hsa-miR-4436b-5p	CLIP-seq
MIRT2499346	hsa-miR-4442	CLIP-seq
MIRT1959375	hsa-miR-4484	CLIP-seq
MIRT2677675	hsa-miR-4486	CLIP-seq
MIRT1959376	hsa-miR-4509	CLIP-seq
MIRT2677676	hsa-miR-4518	CLIP-seq
MIRT2677677	hsa-miR-4530	CLIP-seq
MIRT2499348	hsa-miR-4640-5p	CLIP-seq
MIRT874829	hsa-miR-4668-5p	CLIP-seq
MIRT1959380	hsa-miR-4691-5p	CLIP-seq
MIRT874834	hsa-miR-4698	CLIP-seq
MIRT2499349	hsa-miR-4726-5p	CLIP-seq
MIRT874836	hsa-miR-4757-5p	CLIP-seq
MIRT2677678	hsa-miR-4762-3p	CLIP-seq
MIRT2677679	hsa-miR-4766-5p	CLIP-seq
MIRT1959386	hsa-miR-510	CLIP-seq
MIRT1959390	hsa-miR-548an	CLIP-seq
MIRT2677680	hsa-miR-612	CLIP-seq
MIRT874858	hsa-miR-639	CLIP-seq
MIRT2499350	hsa-miR-661	CLIP-seq
MIRT874859	hsa-miR-665	CLIP-seq
MIRT874860	hsa-miR-720	CLIP-seq
MIRT2677681	hsa-miR-874	CLIP-seq

Gene ontology (GO) Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000244	Process	Spliceosomal tri-snRNP complex assembly	NAS	15840814
GO:0001650	Component	Fibrillar center	IDA
GO:0005515	Function	Protein binding	IPI	9843987, 15105431, 15840814, 16000308, 19389623, 22365833, 25416956, 27173435, 28514442, 31515488, 32296183, 33961781, 35271311, 39251607
GO:0005634	Component	Nucleus	IDA	15840814
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA	15840814
GO:0005682	Component	U5 snRNP	IBA
GO:0005682	Component	U5 snRNP	IDA	15840814
GO:0005682	Component	U5 snRNP	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	9843987
GO:0005829	Component	Cytosol	IDA
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0016607	Component	Nuclear speck	IDA	15840814
GO:0016607	Component	Nuclear speck	IDA
GO:0043021	Function	Ribonucleoprotein complex binding	IDA	15840814
GO:0046540	Component	U4/U6 x U5 tri-snRNP complex	IDA	15840814

Other IDs

• MIM: 604470
• HGNC: 1656
• e!Ensembl: ENSG00000169217

Protein

• UniProt ID: O95400
• Protein name: CD2 antigen cytoplasmic tail-binding protein 2 (CD2 cytoplasmic domain-binding protein 2) (CD2 tail-binding protein 2) (U5 snRNP 52K protein) (U5-52K)
• Protein function: Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly.
• PDB: 1GYF , 1L2Z , 1SYX , 4BWS , 8Q7Q , 8Q7V , 8Q7W , 8Q7X , 8Q91 , 8RC0
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02213	GYF	283 → 332	GYF domain	Domain

• Sequence:

  MPKRKVTFQGVGDEEDEDEIIVPKKKLVDPVAGSGGPGSRFKGKHSLDSDEEEDDDDGGS
  SKYDILASEDVEGQEAATLPSEGGVRITPFNLQEEMEEGHFDADGNYFLNRDAQIRDSWL
  DNIDWVKIRERPPGQRQASDSEEEDSLGQTSMSAQALLEGLLELLLPRETVAGALRRLGA
  RGGGKGRKGPGQPSSPQRLDRLSGLADQMVARGNLGVYQETRERLAMRLKGLGCQTLGPH
  NPTPPPSLDMFAEELAEEELETPTPTQRGEAESRGDGLVDVMWEYKWENTGDAELYGPFT
  SAQMQTWVSEGYFPDGVYCRKLDPPGGQFYNSKRIDFDLYT

• Sequence length: 341

Pathways

Reactome Pathway:

mRNA Splicing - Major Pathway

Related Genes

No strongly related genes found yet for CD2BP2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to CD2BP2.